Systemic Blockade of Clever-1 Elicits Lymphocyte Activation Alongside Checkpoint Molecule Downregulation in Patients with Solid Tumors: Results from a Phase I/II Clinical Trial

Reetta Virtakoivu; Jenna H. Rannikko; Miro Viitala; Felix Vaura; Akira Takeda; Tapio Lonnberg; Jussi Koivunen; Panu Jaakkola; Annika Pasanen; Shishir Shetty; Maja J. A. de Jonge; Debbie Robbrecht; Yuk Ting Ma; Tanja Skyttä; Anna Minchom; Sirpa Jalkanen; Matti K. Karvonen; Jami Mandelin; Petri Bono; Maija Hollmen

doi:10.1158/1078-0432.CCR-20-4862

Systemic Blockade of Clever-1 Elicits Lymphocyte Activation Alongside Checkpoint Molecule Downregulation in Patients with Solid Tumors: Results from a Phase I/II Clinical Trial

Reetta Virtakoivu, Jenna H. Rannikko, Miro Viitala, Felix Vaura, Akira Takeda, Tapio Lonnberg, Jussi Koivunen, Panu Jaakkola, Annika Pasanen, Shishir Shetty, Maja J. A. de Jonge, Debbie Robbrecht, Yuk Ting Ma, Tanja Skyttä, Anna Minchom, Sirpa Jalkanen, Matti K. Karvonen, Jami Mandelin, Petri Bono, Maija Hollmen

Research output: Contribution to journal › Article › Scientific › peer-review

Original language	English
Journal	Clinical Cancer Research
Volume	27
Issue number	15
Pages (from-to)	4205-4220
Number of pages	16
ISSN	1078-0432
DOIs	https://doi.org/10.1158/1078-0432.CCR-20-4862
Publication status	Published - 1 Aug 2021
MoE publication type	A1 Journal article-refereed

Fields of Science

DENDRITIC CELLS
T-CELLS
RECEPTOR
MACROPHAGES
DIFFERENTIATION
HOMEOSTASIS
ENVIRONMENT
STABILIN-1
PATHWAYS
3122 Cancers

Access to Document

10.1158/1078-0432.CCR-20-4862

4205.fullFinal published version, 2.22 MBLicence: CC BY-NC-ND

Cite this

Virtakoivu, R., Rannikko, J. H., Viitala, M., Vaura, F., Takeda, A., Lonnberg, T., Koivunen, J., Jaakkola, P., Pasanen, A., Shetty, S., de Jonge, M. J. A., Robbrecht, D., Ma, Y. T., Skyttä, T., Minchom, A., Jalkanen, S., Karvonen, M. K., Mandelin, J., Bono, P., & Hollmen, M. (2021). Systemic Blockade of Clever-1 Elicits Lymphocyte Activation Alongside Checkpoint Molecule Downregulation in Patients with Solid Tumors: Results from a Phase I/II Clinical Trial. Clinical Cancer Research, 27(15), 4205-4220. https://doi.org/10.1158/1078-0432.CCR-20-4862

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title = "Systemic Blockade of Clever-1 Elicits Lymphocyte Activation Alongside Checkpoint Molecule Downregulation in Patients with Solid Tumors: Results from a Phase I/II Clinical Trial",

keywords = "DENDRITIC CELLS, T-CELLS, RECEPTOR, MACROPHAGES, DIFFERENTIATION, HOMEOSTASIS, ENVIRONMENT, STABILIN-1, PATHWAYS, 3122 Cancers",

author = "Reetta Virtakoivu and Rannikko, {Jenna H.} and Miro Viitala and Felix Vaura and Akira Takeda and Tapio Lonnberg and Jussi Koivunen and Panu Jaakkola and Annika Pasanen and Shishir Shetty and {de Jonge}, {Maja J. A.} and Debbie Robbrecht and Ma, {Yuk Ting} and Tanja Skytt{\"a} and Anna Minchom and Sirpa Jalkanen and Karvonen, {Matti K.} and Jami Mandelin and Petri Bono and Maija Hollmen",

year = "2021",

month = aug,

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doi = "10.1158/1078-0432.CCR-20-4862",

language = "English",

volume = "27",

pages = "4205--4220",

journal = "Clinical Cancer Research",

issn = "1078-0432",

publisher = "American Association for Cancer Research Inc.",

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Virtakoivu, R, Rannikko, JH, Viitala, M, Vaura, F, Takeda, A, Lonnberg, T, Koivunen, J, Jaakkola, P , Pasanen, A, Shetty, S, de Jonge, MJA, Robbrecht, D, Ma, YT, Skyttä, T, Minchom, A, Jalkanen, S, Karvonen, MK, Mandelin, J, Bono, P & Hollmen, M 2021, 'Systemic Blockade of Clever-1 Elicits Lymphocyte Activation Alongside Checkpoint Molecule Downregulation in Patients with Solid Tumors: Results from a Phase I/II Clinical Trial', Clinical Cancer Research, vol. 27, no. 15, pp. 4205-4220. https://doi.org/10.1158/1078-0432.CCR-20-4862

Systemic Blockade of Clever-1 Elicits Lymphocyte Activation Alongside Checkpoint Molecule Downregulation in Patients with Solid Tumors: Results from a Phase I/II Clinical Trial. / Virtakoivu, Reetta; Rannikko, Jenna H.; Viitala, Miro et al.
In: Clinical Cancer Research, Vol. 27, No. 15, 01.08.2021, p. 4205-4220.

Research output: Contribution to journal › Article › Scientific › peer-review

TY - JOUR

T1 - Systemic Blockade of Clever-1 Elicits Lymphocyte Activation Alongside Checkpoint Molecule Downregulation in Patients with Solid Tumors

T2 - Results from a Phase I/II Clinical Trial

AU - Virtakoivu, Reetta

AU - Rannikko, Jenna H.

AU - Viitala, Miro

AU - Vaura, Felix

AU - Takeda, Akira

AU - Lonnberg, Tapio

AU - Koivunen, Jussi

AU - Jaakkola, Panu

AU - Pasanen, Annika

AU - Shetty, Shishir

AU - de Jonge, Maja J. A.

AU - Robbrecht, Debbie

AU - Ma, Yuk Ting

AU - Skyttä, Tanja

AU - Minchom, Anna

AU - Jalkanen, Sirpa

AU - Karvonen, Matti K.

AU - Mandelin, Jami

AU - Bono, Petri

AU - Hollmen, Maija

PY - 2021/8/1

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KW - DENDRITIC CELLS

KW - T-CELLS

KW - RECEPTOR

KW - MACROPHAGES

KW - DIFFERENTIATION

KW - HOMEOSTASIS

KW - ENVIRONMENT

KW - STABILIN-1

KW - PATHWAYS

KW - 3122 Cancers

U2 - 10.1158/1078-0432.CCR-20-4862

DO - 10.1158/1078-0432.CCR-20-4862

M3 - Article

SN - 1078-0432

VL - 27

SP - 4205

EP - 4220

JO - Clinical Cancer Research

JF - Clinical Cancer Research

IS - 15

ER -