Tankyrase inhibition ameliorates lipid disorder via suppression of PGC-1 alpha PARylation in db/db mice

Hong Wang; Sara Kuusela; Rita Rinnankoski-Tuikka; Vincent Dumont; Rim Bouslama; Usama Abo Ramadan; Jo Waaler; Anni-Maija Linden; Nai-Wen Chi; Stefan Krauss; Eija Pirinen; Sanna Lehtonen

doi:10.1038/s41366-020-0573-z

Tankyrase inhibition ameliorates lipid disorder via suppression of PGC-1 alpha PARylation in db/db mice

Hong Wang, Sara Kuusela, Rita Rinnankoski-Tuikka, Vincent Dumont, Rim Bouslama, Usama Abo Ramadan, Jo Waaler, Anni-Maija Linden, Nai-Wen Chi, Stefan Krauss, Eija Pirinen, Sanna Lehtonen

Research output: Contribution to journal › Article › Scientific › peer-review

Original language	English
Journal	International Journal of Obesity
Volume	44
Issue number	8
Pages (from-to)	1691-1702
Number of pages	12
ISSN	0307-0565
DOIs	https://doi.org/10.1038/s41366-020-0573-z
Publication status	Published - Aug 2020
MoE publication type	A1 Journal article-refereed

Fields of Science

FATTY-ACID OXIDATION
RECEPTOR COACTIVATOR PGC-1-ALPHA
BETA-CELL FUNCTION
SKELETAL-MUSCLE
GLUCOSE-METABOLISM
ADIPOSE-TISSUE
PHARMACOLOGICAL INHIBITION
HEPATIC GLUCONEOGENESIS
MITOCHONDRIAL-FUNCTION
PGC-1 COACTIVATORS
3121 General medicine, internal medicine and other clinical medicine
3143 Nutrition

Access to Document

10.1038/s41366-020-0573-z

s41366-020-0573-zFinal published version, 2.05 MBLicence: CC BY

Cite this

Wang, H., Kuusela, S., Rinnankoski-Tuikka, R., Dumont, V., Bouslama, R., Ramadan, U. A., Waaler, J., Linden, A.-M., Chi, N.-W., Krauss, S., Pirinen, E., & Lehtonen, S. (2020). Tankyrase inhibition ameliorates lipid disorder via suppression of PGC-1 alpha PARylation in db/db mice. International Journal of Obesity, 44(8), 1691-1702. https://doi.org/10.1038/s41366-020-0573-z

@article{905455622d394e029a73ee68446dcd1f,

title = "Tankyrase inhibition ameliorates lipid disorder via suppression of PGC-1 alpha PARylation in db/db mice",

keywords = "FATTY-ACID OXIDATION, RECEPTOR COACTIVATOR PGC-1-ALPHA, BETA-CELL FUNCTION, SKELETAL-MUSCLE, GLUCOSE-METABOLISM, ADIPOSE-TISSUE, PHARMACOLOGICAL INHIBITION, HEPATIC GLUCONEOGENESIS, MITOCHONDRIAL-FUNCTION, PGC-1 COACTIVATORS, 3121 General medicine, internal medicine and other clinical medicine, 3143 Nutrition",

author = "Hong Wang and Sara Kuusela and Rita Rinnankoski-Tuikka and Vincent Dumont and Rim Bouslama and Ramadan, {Usama Abo} and Jo Waaler and Anni-Maija Linden and Nai-Wen Chi and Stefan Krauss and Eija Pirinen and Sanna Lehtonen",

year = "2020",

month = aug,

doi = "10.1038/s41366-020-0573-z",

language = "English",

volume = "44",

pages = "1691--1702",

journal = "International Journal of Obesity",

issn = "0307-0565",

publisher = "Springer",

number = "8",

}

Wang, H, Kuusela, S, Rinnankoski-Tuikka, R, Dumont, V, Bouslama, R, Ramadan, UA, Waaler, J, Linden, A-M, Chi, N-W, Krauss, S, Pirinen, E & Lehtonen, S 2020, 'Tankyrase inhibition ameliorates lipid disorder via suppression of PGC-1 alpha PARylation in db/db mice', International Journal of Obesity, vol. 44, no. 8, pp. 1691-1702. https://doi.org/10.1038/s41366-020-0573-z

TY - JOUR

T1 - Tankyrase inhibition ameliorates lipid disorder via suppression of PGC-1 alpha PARylation in db/db mice

AU - Wang, Hong

AU - Kuusela, Sara

AU - Rinnankoski-Tuikka, Rita

AU - Dumont, Vincent

AU - Bouslama, Rim

AU - Ramadan, Usama Abo

AU - Waaler, Jo

AU - Linden, Anni-Maija

AU - Chi, Nai-Wen

AU - Krauss, Stefan

AU - Pirinen, Eija

AU - Lehtonen, Sanna

PY - 2020/8

Y1 - 2020/8

KW - FATTY-ACID OXIDATION

KW - RECEPTOR COACTIVATOR PGC-1-ALPHA

KW - BETA-CELL FUNCTION

KW - SKELETAL-MUSCLE

KW - GLUCOSE-METABOLISM

KW - ADIPOSE-TISSUE

KW - PHARMACOLOGICAL INHIBITION

KW - HEPATIC GLUCONEOGENESIS

KW - MITOCHONDRIAL-FUNCTION

KW - PGC-1 COACTIVATORS

KW - 3121 General medicine, internal medicine and other clinical medicine

KW - 3143 Nutrition

U2 - 10.1038/s41366-020-0573-z

DO - 10.1038/s41366-020-0573-z

M3 - Article

SN - 0307-0565

VL - 44

SP - 1691

EP - 1702

JO - International Journal of Obesity

JF - International Journal of Obesity

IS - 8

ER -