Targeting peptides, a Swiss-army knife against cancer

Research output: Chapter in Book/Report/Conference proceedingChapterScientificpeer-review

Abstract

Characterised by both great selectivity and flexibility, peptides are also considered safe and usually quite well tolerated by patients. During the past two decades, development of anti-cancer peptide therapeutics has formed sustained activity in the research and development (R&D) departments of pharmaceutical industry. Cancer is the emerging leading cause of death worldwide often without a satisfactory therapeutic option available. To overcome the often-acquired chemotherapeutic resistance and side effects, novel drugs that are specifically attacking cancer cells and less toxic to normal cells are required. Thus, tumour targeting peptides constitute an appealing tool for cancer detection and treatment. In this chapter, we will summarise the identification of novel cancer targeting peptides and also address some of the most promising candidates currently under preclinical investigation.
Original languageEnglish
Title of host publicationAmino Acids, Peptides and Proteins
EditorsMaxim Ryadnov, Ferenc Hudecz
Number of pages40
Volume42
PublisherRoyal Society of Chemistry
Publication date2018
Pages281-320
ISBN (Print)978-1-78801-002-3
ISBN (Electronic)978-1-78801-062-7
DOIs
Publication statusPublished - 2018
MoE publication typeA3 Book chapter

Fields of Science

  • 413 Veterinary science

Cite this

Le Joncour, V. J. M., & Laakkonen, P. (2018). Targeting peptides, a Swiss-army knife against cancer. In M. Ryadnov, & F. Hudecz (Eds.), Amino Acids, Peptides and Proteins (Vol. 42, pp. 281-320). Royal Society of Chemistry. https://doi.org/10.1039/9781788010627-00280
Le Joncour, Vadim Jacques Mara ; Laakkonen, Pirjo . / Targeting peptides, a Swiss-army knife against cancer. Amino Acids, Peptides and Proteins. editor / Maxim Ryadnov ; Ferenc Hudecz. Vol. 42 Royal Society of Chemistry, 2018. pp. 281-320
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Le Joncour, VJM & Laakkonen, P 2018, Targeting peptides, a Swiss-army knife against cancer. in M Ryadnov & F Hudecz (eds), Amino Acids, Peptides and Proteins. vol. 42, Royal Society of Chemistry, pp. 281-320. https://doi.org/10.1039/9781788010627-00280

Targeting peptides, a Swiss-army knife against cancer. / Le Joncour, Vadim Jacques Mara; Laakkonen, Pirjo .

Amino Acids, Peptides and Proteins. ed. / Maxim Ryadnov; Ferenc Hudecz. Vol. 42 Royal Society of Chemistry, 2018. p. 281-320.

Research output: Chapter in Book/Report/Conference proceedingChapterScientificpeer-review

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AB - Characterised by both great selectivity and flexibility, peptides are also considered safe and usually quite well tolerated by patients. During the past two decades, development of anti-cancer peptide therapeutics has formed sustained activity in the research and development (R&D) departments of pharmaceutical industry. Cancer is the emerging leading cause of death worldwide often without a satisfactory therapeutic option available. To overcome the often-acquired chemotherapeutic resistance and side effects, novel drugs that are specifically attacking cancer cells and less toxic to normal cells are required. Thus, tumour targeting peptides constitute an appealing tool for cancer detection and treatment. In this chapter, we will summarise the identification of novel cancer targeting peptides and also address some of the most promising candidates currently under preclinical investigation.

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Le Joncour VJM, Laakkonen P. Targeting peptides, a Swiss-army knife against cancer. In Ryadnov M, Hudecz F, editors, Amino Acids, Peptides and Proteins. Vol. 42. Royal Society of Chemistry. 2018. p. 281-320 https://doi.org/10.1039/9781788010627-00280