Testosterone is associated with insulin resistance index independently of adiposity in women with polycystic ovary syndrome

Kari Luotola, Terhi T Piltonen, Johanna Puurunen, Laure C Morin-Papunen, Juha S Tapanainen

Research output: Contribution to journalArticleScientificpeer-review

Abstract

Objective: To study the associations between androgens, glucose homeostasis, inflammation and statin treatment in women with polycystic ovary syndrome (PCOS).

Design and methods: Oral glucose tolerance tests, androgens, hs-CRP and interleukin-1 receptor antagonist (IL-1Ra) were analyzed at baseline and after 6months of atorvastatin (20 mg/d) or placebo treatment in 27 women with PCOS.

Results: Testosterone associated with insulin resistance measured with ISIMatsuda independently of BMI, age and SHBG concentrations and the full model, including IL-1Ra, hs-CRP and HDL-C, also showed independency of BMI and waist circumference (p≤.042). Free androgen index (FAI) associated with ISIMatsuda independently of adiposity (p≤.025) but in the full model with waist circumference the association was insignificant. ISIMatsuda decreased with testosterone >1.2nmol/l compared with lower levels at baseline (p=.043) and at six months (p=.003). Accordingly, 30-minute insulin levels were increased with moderately elevated testosterone independently of adiposity (p≤.046). Increased fasting glucose and AUC insulin associated with statin treatment independently of adiposity and the associations attenuated after adjusting for testosterone.

 Conclusions: Moderately elevated testosterone concentrations together with obesity-related inflammatory factors modify glucose homeostasis by increasing insulin resistance and early insulin secretion.

Original languageEnglish
JournalGynecological Endocrinology
Volume34
Issue number1
Pages (from-to)40-44
Number of pages5
ISSN0951-3590
DOIs
Publication statusPublished - 2018
MoE publication typeA1 Journal article-refereed

Fields of Science

  • 3121 Internal medicine
  • 3123 Gynaecology and paediatrics
  • Insulin secretion
  • insulin sensitivity
  • inflammation polycystic ovary syndrome
  • adiposity
  • androgens
  • IL-1 RECEPTOR ANTAGONIST
  • GLUCOSE-TOLERANCE
  • METABOLIC SYNDROME
  • PROSPECTIVE COHORT
  • DOUBLE-BLIND
  • FOLLOW-UP
  • SIMVASTATIN
  • SENSITIVITY
  • TRIAL
  • PCOS

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