The genetic architecture of HIV-1 virulence

Francois Blanquart; Chris Wymant; Matthew Hall; Robert Power; Tanya Golubchik; Astrid Gall; Mariateresa De Cesare; George Macintyre-Cockett; Margreet Bakker; Daniela Bezemer; Migle Gabrielaite; Swee Hoe Ong; Michelle Kendall; Rafael Sauter; Norbert Bannert; Jacques Fellay; M. Kate Grabowski; Barbara Gunsenheimer-Bartmeyer; Huldrych F. Gunthard; Pia Kivelä; Roger D. Kouyos; Oliver Laeyendecker; Rasmus L. Marvig; Karolin Meixenberger; Laurence Meyer; Ard van Sighem; David Bonsall; Marc Van Der Valk; Ben Berkhout; Paul Kellam; Marion Cornelissen; Peter Reiss; Christophe Fraser

doi:10.1093/ve/veaf057

The genetic architecture of HIV-1 virulence

Francois Blanquart
, Chris Wymant
, Matthew Hall
, Robert Power
, Tanya Golubchik
, Astrid Gall
, Mariateresa De Cesare
, George Macintyre-Cockett
, Margreet Bakker
, Daniela Bezemer
, Migle Gabrielaite
, Swee Hoe Ong
, Michelle Kendall
, Rafael Sauter
, Norbert Bannert
, Jacques Fellay
, M. Kate Grabowski
, Barbara Gunsenheimer-Bartmeyer
, Huldrych F. Gunthard
, Pia Kivelä

Roger D. Kouyos, Oliver Laeyendecker, Rasmus L. Marvig, Karolin Meixenberger, Laurence Meyer, Ard van Sighem, David Bonsall, Marc Van Der Valk, Ben Berkhout, Paul Kellam, Marion Cornelissen, Peter Reiss, Christophe Fraser

Research output: Contribution to journal › Article › Scientific › peer-review

Original language	English
Article number	veaf057
Journal	Virus evolution
Volume	11
Issue number	1
Number of pages	17
ISSN	2057-1577
DOIs	https://doi.org/10.1093/ve/veaf057
Publication status	Published - 2025
MoE publication type	A1 Journal article-refereed

Fields of Science

CTL escape
Hiv-1
Genome-wide association study
Polygenic trait
Virulence
11832 Microbiology and virology
1184 Genetics, developmental biology, physiology
3121 General medicine, internal medicine and other clinical medicine

Access to Document

10.1093/ve/veaf057

veaf057Final published version, 3.63 MBLicence: CC BY-NC

Cite this

Blanquart, F., Wymant, C., Hall, M., Power, R., Golubchik, T., Gall, A., De Cesare, M., Macintyre-Cockett, G., Bakker, M., Bezemer, D., Gabrielaite, M., Ong, S. H., Kendall, M., Sauter, R., Bannert, N., Fellay, J., Grabowski, M. K., Gunsenheimer-Bartmeyer, B., Gunthard, H. F., ... Fraser, C. (2025). The genetic architecture of HIV-1 virulence. Virus evolution, 11(1), Article veaf057. https://doi.org/10.1093/ve/veaf057

@article{5d1ee2394758469fb11deb0f82133700,

title = "The genetic architecture of HIV-1 virulence",

keywords = "CTL escape, Hiv-1, Genome-wide association study, Polygenic trait, Virulence, 11832 Microbiology and virology, 1184 Genetics, developmental biology, physiology, 3121 General medicine, internal medicine and other clinical medicine",

author = "Francois Blanquart and Chris Wymant and Matthew Hall and Robert Power and Tanya Golubchik and Astrid Gall and \{De Cesare\}, Mariateresa and George Macintyre-Cockett and Margreet Bakker and Daniela Bezemer and Migle Gabrielaite and Ong, \{Swee Hoe\} and Michelle Kendall and Rafael Sauter and Norbert Bannert and Jacques Fellay and Grabowski, \{M. Kate\} and Barbara Gunsenheimer-Bartmeyer and Gunthard, \{Huldrych F.\} and Pia Kivel{\"a} and Kouyos, \{Roger D.\} and Oliver Laeyendecker and Marvig, \{Rasmus L.\} and Karolin Meixenberger and Laurence Meyer and \{van Sighem\}, Ard and David Bonsall and \{Van Der Valk\}, Marc and Ben Berkhout and Paul Kellam and Marion Cornelissen and Peter Reiss and Christophe Fraser",

year = "2025",

doi = "10.1093/ve/veaf057",

language = "English",

volume = "11",

journal = "Virus evolution",

issn = "2057-1577",

publisher = "Oxford University Press",

number = "1",

}

Blanquart, F, Wymant, C, Hall, M, Power, R, Golubchik, T, Gall, A, De Cesare, M, Macintyre-Cockett, G, Bakker, M, Bezemer, D, Gabrielaite, M, Ong, SH, Kendall, M, Sauter, R, Bannert, N, Fellay, J, Grabowski, MK, Gunsenheimer-Bartmeyer, B, Gunthard, HF, Kivelä, P, Kouyos, RD, Laeyendecker, O, Marvig, RL, Meixenberger, K, Meyer, L, van Sighem, A, Bonsall, D, Van Der Valk, M, Berkhout, B, Kellam, P, Cornelissen, M, Reiss, P & Fraser, C 2025, 'The genetic architecture of HIV-1 virulence', Virus evolution, vol. 11, no. 1, veaf057. https://doi.org/10.1093/ve/veaf057

TY - JOUR

T1 - The genetic architecture of HIV-1 virulence

AU - Blanquart, Francois

AU - Wymant, Chris

AU - Hall, Matthew

AU - Power, Robert

AU - Golubchik, Tanya

AU - Gall, Astrid

AU - De Cesare, Mariateresa

AU - Macintyre-Cockett, George

AU - Bakker, Margreet

AU - Bezemer, Daniela

AU - Gabrielaite, Migle

AU - Ong, Swee Hoe

AU - Kendall, Michelle

AU - Sauter, Rafael

AU - Bannert, Norbert

AU - Fellay, Jacques

AU - Grabowski, M. Kate

AU - Gunsenheimer-Bartmeyer, Barbara

AU - Gunthard, Huldrych F.

AU - Kivelä, Pia

AU - Kouyos, Roger D.

AU - Laeyendecker, Oliver

AU - Marvig, Rasmus L.

AU - Meixenberger, Karolin

AU - Meyer, Laurence

AU - van Sighem, Ard

AU - Bonsall, David

AU - Van Der Valk, Marc

AU - Berkhout, Ben

AU - Kellam, Paul

AU - Cornelissen, Marion

AU - Reiss, Peter

AU - Fraser, Christophe

PY - 2025

Y1 - 2025

KW - CTL escape

KW - Hiv-1

KW - Genome-wide association study

KW - Polygenic trait

KW - Virulence

KW - 11832 Microbiology and virology

KW - 1184 Genetics, developmental biology, physiology

KW - 3121 General medicine, internal medicine and other clinical medicine

U2 - 10.1093/ve/veaf057

DO - 10.1093/ve/veaf057

M3 - Article

C2 - 41368623

SN - 2057-1577

VL - 11

JO - Virus evolution

JF - Virus evolution

IS - 1

M1 - veaf057

ER -