The Human Microbiome in Parkinson’s Disease and Primary Sclerosing Cholangitis

Research output: ThesisDoctoral Thesis

Abstract

Parkinson’s disease (PD) and Primary Sclerosing Cholangitis (PSC) are idiopathic diseases for which an external agent, e.g. a microorganism, has been hypothesised as being causally related to the condition or as having a potential role in disease progression. In the present work, we present evidence that gut and oral microbiota, but not nasal, differ between controls and PD patients, and that, regardless of hypothetical causal relationships, some of these changes show potential for use as biomarkers for diagnostic purposes. Although none of our studies are designed to investigate causality, we nevertheless find no suggestion that the bile microbiota is aetiologically related to PSC. On the other hand, our results suggest that Streptococcus may contribute to disease progression. All the studies are unified by the same methodology, consisting on case-control studies using high-throughput amplicon sequencing of the bacterial 16S rRNA gene, followed by bioinformatic processing of the raw data, and finally by statistical analysis.
Original languageEnglish
Awarding Institution
  • University of Helsinki
Supervisors/Advisors
  • Auvinen, Petri, Supervisor
Award date22 Sep 2017
Place of PublicationHelsinki
Publisher
Print ISBNs978-951-51-3607-7
Electronic ISBNs978-951-51-3608-4
Publication statusPublished - 22 Sep 2017
MoE publication typeG5 Doctoral dissertation (article)

Fields of Science

  • 1184 Genetics, developmental biology, physiology
  • 3111 Biomedicine
  • 3112 Neurosciences

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