The human prion gene M129V polymorphism is not associated with idiopathic Parkinson's disease in three distinct populations

Sonja Scholz; Georgia Xiromerisiou; Hon C Fung; Johanna Eerola-Rautio; Olli Hellström; Alexandros Paåadimitriou; Georgios M Hadjigeorgiou; Pentti J Tienari; Hubert H Fernandez; Ronald Mandel; Michael S Okun; Katharina Gwinn-Hardy; Andrew B Singleton

doi:10.1016/j.neulet.2005.10.081

The human prion gene M129V polymorphism is not associated with idiopathic Parkinson's disease in three distinct populations

Sonja Scholz, Georgia Xiromerisiou, Hon C Fung, Johanna Eerola-Rautio, Olli Hellström, Alexandros Paåadimitriou, Georgios M Hadjigeorgiou, Pentti J Tienari, Hubert H Fernandez, Ronald Mandel, Michael S Okun, Katharina Gwinn-Hardy, Andrew B Singleton

Research output: Contribution to journal › Article › Scientific › peer-review

Abstract

Coexistence of prion disease and idiopathic Parkinson's disease (TPD) has been previously described. It remains unclear whether this relationship may reflect the high incidence of IPD or whether both prion and IPD share common pathogenetic mechanisms. For this reason, we investigated the genotype distribution of the M129V polymorphism of the human prion gene for association with IPD (controls: n = 398, IPD cases: n =400). No association between genotypes in codon 129 and IPD was detected in three distinct Populations, suggesting that this PRNP polymorphism has no direct influence on the susceptibility to IPD. Published by Elsevier Ireland Ltd.

Original language	English
Journal	Neuroscience Letters
Volume	395
Pages (from-to)	227-229
Number of pages	3
ISSN	0304-3940
DOIs	https://doi.org/10.1016/j.neulet.2005.10.081
Publication status	Published - 2006
MoE publication type	A1 Journal article-refereed

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10.1016/j.neulet.2005.10.081

Cite this

Scholz, S., Xiromerisiou, G., Fung, H. C., Eerola-Rautio, J., Hellström, O., Paåadimitriou, A., Hadjigeorgiou, G. M., Tienari, P. J., Fernandez, H. H., Mandel, R., Okun, M. S., Gwinn-Hardy, K., & Singleton, A. B. (2006). The human prion gene M129V polymorphism is not associated with idiopathic Parkinson's disease in three distinct populations. Neuroscience Letters, 395, 227-229. https://doi.org/10.1016/j.neulet.2005.10.081

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title = "The human prion gene M129V polymorphism is not associated with idiopathic Parkinson's disease in three distinct populations",

abstract = "Coexistence of prion disease and idiopathic Parkinson's disease (TPD) has been previously described. It remains unclear whether this relationship may reflect the high incidence of IPD or whether both prion and IPD share common pathogenetic mechanisms. For this reason, we investigated the genotype distribution of the M129V polymorphism of the human prion gene for association with IPD (controls: n = 398, IPD cases: n =400). No association between genotypes in codon 129 and IPD was detected in three distinct Populations, suggesting that this PRNP polymorphism has no direct influence on the susceptibility to IPD. Published by Elsevier Ireland Ltd.",

author = "Sonja Scholz and Georgia Xiromerisiou and Fung, {Hon C} and Johanna Eerola-Rautio and Olli Hellstr{\"o}m and Alexandros Pa{\aa}adimitriou and Hadjigeorgiou, {Georgios M} and Tienari, {Pentti J} and Fernandez, {Hubert H} and Ronald Mandel and Okun, {Michael S} and Katharina Gwinn-Hardy and Singleton, {Andrew B}",

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language = "English",

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Scholz, S, Xiromerisiou, G, Fung, HC, Eerola-Rautio, J, Hellström, O, Paåadimitriou, A, Hadjigeorgiou, GM, Tienari, PJ, Fernandez, HH, Mandel, R, Okun, MS, Gwinn-Hardy, K & Singleton, AB 2006, 'The human prion gene M129V polymorphism is not associated with idiopathic Parkinson's disease in three distinct populations', Neuroscience Letters, vol. 395, pp. 227-229. https://doi.org/10.1016/j.neulet.2005.10.081

TY - JOUR

T1 - The human prion gene M129V polymorphism is not associated with idiopathic Parkinson's disease in three distinct populations

AU - Scholz, Sonja

AU - Xiromerisiou, Georgia

AU - Fung, Hon C

AU - Eerola-Rautio, Johanna

AU - Hellström, Olli

AU - Paåadimitriou, Alexandros

AU - Hadjigeorgiou, Georgios M

AU - Tienari, Pentti J

AU - Fernandez, Hubert H

AU - Mandel, Ronald

AU - Okun, Michael S

AU - Gwinn-Hardy, Katharina

AU - Singleton, Andrew B

PY - 2006

Y1 - 2006

N2 - Coexistence of prion disease and idiopathic Parkinson's disease (TPD) has been previously described. It remains unclear whether this relationship may reflect the high incidence of IPD or whether both prion and IPD share common pathogenetic mechanisms. For this reason, we investigated the genotype distribution of the M129V polymorphism of the human prion gene for association with IPD (controls: n = 398, IPD cases: n =400). No association between genotypes in codon 129 and IPD was detected in three distinct Populations, suggesting that this PRNP polymorphism has no direct influence on the susceptibility to IPD. Published by Elsevier Ireland Ltd.

AB - Coexistence of prion disease and idiopathic Parkinson's disease (TPD) has been previously described. It remains unclear whether this relationship may reflect the high incidence of IPD or whether both prion and IPD share common pathogenetic mechanisms. For this reason, we investigated the genotype distribution of the M129V polymorphism of the human prion gene for association with IPD (controls: n = 398, IPD cases: n =400). No association between genotypes in codon 129 and IPD was detected in three distinct Populations, suggesting that this PRNP polymorphism has no direct influence on the susceptibility to IPD. Published by Elsevier Ireland Ltd.

U2 - 10.1016/j.neulet.2005.10.081

DO - 10.1016/j.neulet.2005.10.081

M3 - Article

SN - 0304-3940

VL - 395

SP - 227

EP - 229

JO - Neuroscience Letters

JF - Neuroscience Letters

ER -