TY - JOUR
T1 - The human prion gene M129V polymorphism is not associated with idiopathic Parkinson's disease in three distinct populations
AU - Scholz, Sonja
AU - Xiromerisiou, Georgia
AU - Fung, Hon C
AU - Eerola-Rautio, Johanna
AU - Hellström, Olli
AU - Paåadimitriou, Alexandros
AU - Hadjigeorgiou, Georgios M
AU - Tienari, Pentti J
AU - Fernandez, Hubert H
AU - Mandel, Ronald
AU - Okun, Michael S
AU - Gwinn-Hardy, Katharina
AU - Singleton, Andrew B
PY - 2006
Y1 - 2006
N2 - Coexistence of prion disease and idiopathic Parkinson's disease (TPD) has been previously described. It remains unclear whether this relationship may reflect the high incidence of IPD or whether both prion and IPD share common pathogenetic mechanisms. For this reason, we investigated the genotype distribution of the M129V polymorphism of the human prion gene for association with IPD (controls: n = 398, IPD cases: n =400). No association between genotypes in codon 129 and IPD was detected in three distinct Populations, suggesting that this PRNP polymorphism has no direct influence on the susceptibility to IPD. Published by Elsevier Ireland Ltd.
AB - Coexistence of prion disease and idiopathic Parkinson's disease (TPD) has been previously described. It remains unclear whether this relationship may reflect the high incidence of IPD or whether both prion and IPD share common pathogenetic mechanisms. For this reason, we investigated the genotype distribution of the M129V polymorphism of the human prion gene for association with IPD (controls: n = 398, IPD cases: n =400). No association between genotypes in codon 129 and IPD was detected in three distinct Populations, suggesting that this PRNP polymorphism has no direct influence on the susceptibility to IPD. Published by Elsevier Ireland Ltd.
U2 - 10.1016/j.neulet.2005.10.081
DO - 10.1016/j.neulet.2005.10.081
M3 - Article
SN - 0304-3940
VL - 395
SP - 227
EP - 229
JO - Neuroscience Letters
JF - Neuroscience Letters
ER -