The impact of low-frequency and rare variants on lipid levels

Ida Surakka, Momoko Horikoshi, Reedik Magi, Antti-Pekka Sarin, Anubha Mahajan, Vasiliki Lagou, Letizia Marullo, Teresa Ferreira, Benjamin Miraglio, Sanna Timonen, Johannes Kettunen, Matti Pirinen, Julia Karjalainen, Gudmar Thorleifsson, Sara Hagg, Jouke-Jan Hottenga, Aaron Isaacs, Claes Ladenvall, Marian Beekman, Tonu Esko & 31 others Janina S. Ried, Christopher P. Nelson, Christina Willenborg, Stefan Gustafsson, Harm-Jan Westra, Matthew Blades, Anton J. M. de Craen, Eco J. de Geus, Joris Deelen, Harald Grallert, Anders Hamsten, Aki S. Havulinna, Christian Hengstenberg, Jeanine J. Houwing-Duistermaat, Elina Hypponen, Lennart C. Karssen, Terho Lehtimaki, Valeriya Lyssenko, Patrik K. E. Magnusson, Evelin Mihailov, John-Patrick Mpindi, Markus Perola, Jaakko Kaprio, Leif Groop, Johan G. Eriksson, Elina Ikonen, Olli Kallioniemi, Vilja Pietiainen, Aarno Palotie, Samuli Ripatti, ENGAGE Consortium

Research output: Contribution to journalArticleScientificpeer-review

Original languageEnglish
JournalNature Genetics
Volume47
Issue number6
Pages (from-to)589-597
Number of pages9
ISSN1061-4036
DOIs
Publication statusPublished - Jun 2015
MoE publication typeA1 Journal article-refereed

Fields of Science

  • GENOME-WIDE ASSOCIATION
  • IN-VITRO
  • HETEROGENEITY
  • EXPRESSION
  • SIALOMUCIN
  • SEQUENCE
  • DISEASE
  • GLUCOSE
  • GENES
  • LIVER
  • 3111 Biomedicine
  • 1184 Genetics, developmental biology, physiology
  • 3142 Public health care science, environmental and occupational health

Cite this

Surakka, I., Horikoshi, M., Magi, R., Sarin, A-P., Mahajan, A., Lagou, V., ... ENGAGE Consortium (2015). The impact of low-frequency and rare variants on lipid levels. Nature Genetics, 47(6), 589-597. https://doi.org/10.1038/ng.3300
Surakka, Ida ; Horikoshi, Momoko ; Magi, Reedik ; Sarin, Antti-Pekka ; Mahajan, Anubha ; Lagou, Vasiliki ; Marullo, Letizia ; Ferreira, Teresa ; Miraglio, Benjamin ; Timonen, Sanna ; Kettunen, Johannes ; Pirinen, Matti ; Karjalainen, Julia ; Thorleifsson, Gudmar ; Hagg, Sara ; Hottenga, Jouke-Jan ; Isaacs, Aaron ; Ladenvall, Claes ; Beekman, Marian ; Esko, Tonu ; Ried, Janina S. ; Nelson, Christopher P. ; Willenborg, Christina ; Gustafsson, Stefan ; Westra, Harm-Jan ; Blades, Matthew ; de Craen, Anton J. M. ; de Geus, Eco J. ; Deelen, Joris ; Grallert, Harald ; Hamsten, Anders ; Havulinna, Aki S. ; Hengstenberg, Christian ; Houwing-Duistermaat, Jeanine J. ; Hypponen, Elina ; Karssen, Lennart C. ; Lehtimaki, Terho ; Lyssenko, Valeriya ; Magnusson, Patrik K. E. ; Mihailov, Evelin ; Mpindi, John-Patrick ; Perola, Markus ; Kaprio, Jaakko ; Groop, Leif ; Eriksson, Johan G. ; Ikonen, Elina ; Kallioniemi, Olli ; Pietiainen, Vilja ; Palotie, Aarno ; Ripatti, Samuli ; ENGAGE Consortium. / The impact of low-frequency and rare variants on lipid levels. In: Nature Genetics. 2015 ; Vol. 47, No. 6. pp. 589-597.
@article{bff09f4dcff04737b16d36e618dd471d,
title = "The impact of low-frequency and rare variants on lipid levels",
keywords = "GENOME-WIDE ASSOCIATION, IN-VITRO, HETEROGENEITY, EXPRESSION, SIALOMUCIN, SEQUENCE, DISEASE, GLUCOSE, GENES, LIVER, 3111 Biomedicine, 1184 Genetics, developmental biology, physiology, 3142 Public health care science, environmental and occupational health",
author = "Ida Surakka and Momoko Horikoshi and Reedik Magi and Antti-Pekka Sarin and Anubha Mahajan and Vasiliki Lagou and Letizia Marullo and Teresa Ferreira and Benjamin Miraglio and Sanna Timonen and Johannes Kettunen and Matti Pirinen and Julia Karjalainen and Gudmar Thorleifsson and Sara Hagg and Jouke-Jan Hottenga and Aaron Isaacs and Claes Ladenvall and Marian Beekman and Tonu Esko and Ried, {Janina S.} and Nelson, {Christopher P.} and Christina Willenborg and Stefan Gustafsson and Harm-Jan Westra and Matthew Blades and {de Craen}, {Anton J. M.} and {de Geus}, {Eco J.} and Joris Deelen and Harald Grallert and Anders Hamsten and Havulinna, {Aki S.} and Christian Hengstenberg and Houwing-Duistermaat, {Jeanine J.} and Elina Hypponen and Karssen, {Lennart C.} and Terho Lehtimaki and Valeriya Lyssenko and Magnusson, {Patrik K. E.} and Evelin Mihailov and John-Patrick Mpindi and Markus Perola and Jaakko Kaprio and Leif Groop and Eriksson, {Johan G.} and Elina Ikonen and Olli Kallioniemi and Vilja Pietiainen and Aarno Palotie and Samuli Ripatti and {ENGAGE Consortium}",
year = "2015",
month = "6",
doi = "10.1038/ng.3300",
language = "English",
volume = "47",
pages = "589--597",
journal = "Nature Genetics",
issn = "1061-4036",
publisher = "Nature Publishing Group",
number = "6",

}

Surakka, I, Horikoshi, M, Magi, R, Sarin, A-P, Mahajan, A, Lagou, V, Marullo, L, Ferreira, T, Miraglio, B, Timonen, S, Kettunen, J, Pirinen, M, Karjalainen, J, Thorleifsson, G, Hagg, S, Hottenga, J-J, Isaacs, A, Ladenvall, C, Beekman, M, Esko, T, Ried, JS, Nelson, CP, Willenborg, C, Gustafsson, S, Westra, H-J, Blades, M, de Craen, AJM, de Geus, EJ, Deelen, J, Grallert, H, Hamsten, A, Havulinna, AS, Hengstenberg, C, Houwing-Duistermaat, JJ, Hypponen, E, Karssen, LC, Lehtimaki, T, Lyssenko, V, Magnusson, PKE, Mihailov, E, Mpindi, J-P, Perola, M, Kaprio, J, Groop, L, Eriksson, JG, Ikonen, E, Kallioniemi, O, Pietiainen, V, Palotie, A, Ripatti, S & ENGAGE Consortium 2015, 'The impact of low-frequency and rare variants on lipid levels', Nature Genetics, vol. 47, no. 6, pp. 589-597. https://doi.org/10.1038/ng.3300

The impact of low-frequency and rare variants on lipid levels. / Surakka, Ida; Horikoshi, Momoko; Magi, Reedik; Sarin, Antti-Pekka; Mahajan, Anubha; Lagou, Vasiliki; Marullo, Letizia; Ferreira, Teresa; Miraglio, Benjamin; Timonen, Sanna; Kettunen, Johannes; Pirinen, Matti; Karjalainen, Julia; Thorleifsson, Gudmar; Hagg, Sara; Hottenga, Jouke-Jan; Isaacs, Aaron; Ladenvall, Claes; Beekman, Marian; Esko, Tonu; Ried, Janina S.; Nelson, Christopher P.; Willenborg, Christina; Gustafsson, Stefan; Westra, Harm-Jan; Blades, Matthew; de Craen, Anton J. M.; de Geus, Eco J.; Deelen, Joris; Grallert, Harald; Hamsten, Anders; Havulinna, Aki S.; Hengstenberg, Christian; Houwing-Duistermaat, Jeanine J.; Hypponen, Elina; Karssen, Lennart C.; Lehtimaki, Terho; Lyssenko, Valeriya; Magnusson, Patrik K. E.; Mihailov, Evelin; Mpindi, John-Patrick; Perola, Markus; Kaprio, Jaakko; Groop, Leif; Eriksson, Johan G.; Ikonen, Elina; Kallioniemi, Olli; Pietiainen, Vilja; Palotie, Aarno; Ripatti, Samuli; ENGAGE Consortium.

In: Nature Genetics, Vol. 47, No. 6, 06.2015, p. 589-597.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - The impact of low-frequency and rare variants on lipid levels

AU - Surakka, Ida

AU - Horikoshi, Momoko

AU - Magi, Reedik

AU - Sarin, Antti-Pekka

AU - Mahajan, Anubha

AU - Lagou, Vasiliki

AU - Marullo, Letizia

AU - Ferreira, Teresa

AU - Miraglio, Benjamin

AU - Timonen, Sanna

AU - Kettunen, Johannes

AU - Pirinen, Matti

AU - Karjalainen, Julia

AU - Thorleifsson, Gudmar

AU - Hagg, Sara

AU - Hottenga, Jouke-Jan

AU - Isaacs, Aaron

AU - Ladenvall, Claes

AU - Beekman, Marian

AU - Esko, Tonu

AU - Ried, Janina S.

AU - Nelson, Christopher P.

AU - Willenborg, Christina

AU - Gustafsson, Stefan

AU - Westra, Harm-Jan

AU - Blades, Matthew

AU - de Craen, Anton J. M.

AU - de Geus, Eco J.

AU - Deelen, Joris

AU - Grallert, Harald

AU - Hamsten, Anders

AU - Havulinna, Aki S.

AU - Hengstenberg, Christian

AU - Houwing-Duistermaat, Jeanine J.

AU - Hypponen, Elina

AU - Karssen, Lennart C.

AU - Lehtimaki, Terho

AU - Lyssenko, Valeriya

AU - Magnusson, Patrik K. E.

AU - Mihailov, Evelin

AU - Mpindi, John-Patrick

AU - Perola, Markus

AU - Kaprio, Jaakko

AU - Groop, Leif

AU - Eriksson, Johan G.

AU - Ikonen, Elina

AU - Kallioniemi, Olli

AU - Pietiainen, Vilja

AU - Palotie, Aarno

AU - Ripatti, Samuli

AU - ENGAGE Consortium

PY - 2015/6

Y1 - 2015/6

KW - GENOME-WIDE ASSOCIATION

KW - IN-VITRO

KW - HETEROGENEITY

KW - EXPRESSION

KW - SIALOMUCIN

KW - SEQUENCE

KW - DISEASE

KW - GLUCOSE

KW - GENES

KW - LIVER

KW - 3111 Biomedicine

KW - 1184 Genetics, developmental biology, physiology

KW - 3142 Public health care science, environmental and occupational health

U2 - 10.1038/ng.3300

DO - 10.1038/ng.3300

M3 - Article

VL - 47

SP - 589

EP - 597

JO - Nature Genetics

JF - Nature Genetics

SN - 1061-4036

IS - 6

ER -

Surakka I, Horikoshi M, Magi R, Sarin A-P, Mahajan A, Lagou V et al. The impact of low-frequency and rare variants on lipid levels. Nature Genetics. 2015 Jun;47(6):589-597. https://doi.org/10.1038/ng.3300