The initiation of post-synaptic protrusions

Research output: Contribution to journalArticleScientificpeer-review

Abstract

The post-synaptic spines of neuronal dendrites are highly elaborate membrane protrusions. Their anatomy, stability and density are intimately linked to cognitive performance. The morphological transitions of spines are powered by coordinated polymerization of actin filaments against the plasma membrane, but how the membrane-associated polymerization is spatially and temporally regulated has remained ill defined. Here, we discuss our recent findings showing that dendritic spines can be initiated by direct membrane bending by the I-BAR protein MIM/Mtss1. This lipid phosphatidylinositol (PI(4,5)P2) signaling-activated membrane bending coordinated spatial actin assembly and promoted spine formation. From recent advances, we formulate a general model to discuss how spatially concentrated protein-lipid microdomains formed by multivalent interactions between lipids and actin/membrane regulatory proteins might launch cell protrusions. © 2016 The Author(s). Published with license by Taylor & Francis Group, LLC, Pirta Hotulainen and Juha Saarikangas.
Original languageEnglish
JournalCommunicative & integrative biology
Volume9
Issue number3
DOIs
Publication statusPublished - 2016
MoE publication typeA1 Journal article-refereed

Bibliographical note

cited By 0

Fields of Science

  • 3112 Neurosciences

Cite this

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The initiation of post-synaptic protrusions. / Hotulainen, P.; Saarikangas, J.

In: Communicative & integrative biology , Vol. 9, No. 3, 2016.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - The initiation of post-synaptic protrusions

AU - Hotulainen, P.

AU - Saarikangas, J.

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N2 - The post-synaptic spines of neuronal dendrites are highly elaborate membrane protrusions. Their anatomy, stability and density are intimately linked to cognitive performance. The morphological transitions of spines are powered by coordinated polymerization of actin filaments against the plasma membrane, but how the membrane-associated polymerization is spatially and temporally regulated has remained ill defined. Here, we discuss our recent findings showing that dendritic spines can be initiated by direct membrane bending by the I-BAR protein MIM/Mtss1. This lipid phosphatidylinositol (PI(4,5)P2) signaling-activated membrane bending coordinated spatial actin assembly and promoted spine formation. From recent advances, we formulate a general model to discuss how spatially concentrated protein-lipid microdomains formed by multivalent interactions between lipids and actin/membrane regulatory proteins might launch cell protrusions. © 2016 The Author(s). Published with license by Taylor & Francis Group, LLC, Pirta Hotulainen and Juha Saarikangas.

AB - The post-synaptic spines of neuronal dendrites are highly elaborate membrane protrusions. Their anatomy, stability and density are intimately linked to cognitive performance. The morphological transitions of spines are powered by coordinated polymerization of actin filaments against the plasma membrane, but how the membrane-associated polymerization is spatially and temporally regulated has remained ill defined. Here, we discuss our recent findings showing that dendritic spines can be initiated by direct membrane bending by the I-BAR protein MIM/Mtss1. This lipid phosphatidylinositol (PI(4,5)P2) signaling-activated membrane bending coordinated spatial actin assembly and promoted spine formation. From recent advances, we formulate a general model to discuss how spatially concentrated protein-lipid microdomains formed by multivalent interactions between lipids and actin/membrane regulatory proteins might launch cell protrusions. © 2016 The Author(s). Published with license by Taylor & Francis Group, LLC, Pirta Hotulainen and Juha Saarikangas.

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