The Multifaceted Roles of KCC2 in Cortical Development

Research output: Contribution to journalReview Articlepeer-review

Abstract

KCC2, best known as the neuron-specific chloride-extruder that sets the strength and polarity of GABAergic currents during neuronal maturation, isa multifunctional molecule that can regulate cytoskeletal dynamics via its C-terminal domain (CTD). We describe the molecular and cellular mechanisms involved in the multiple functions of KCC2 and its splice variants, ranging from developmental apoptosis and the control of early network events to the formation and plasticity of cortical dendritic spines. The versatility of KCC2 actions at the cellular and subcellular levels is also evident in mature neurons during plasticity, disease, and aging. Thus, KCC2 has emerged as one of the most important molecules that shape the overall neuronal phenotype.

Original languageEnglish
JournalTrends in Neurosciences
Volume44
Issue number5
Pages (from-to)378-392
Number of pages15
ISSN0166-2236
DOIs
Publication statusPublished - May 2021
MoE publication typeA2 Review article in a scientific journal

Fields of Science

  • 3112 Neurosciences
  • K-CL COTRANSPORTER
  • CATION-CHLORIDE COTRANSPORTERS
  • CRYO-EM STRUCTURES
  • NEURONAL-ACTIVITY
  • DENDRITIC SPINES
  • ION-TRANSPORT
  • SPAK/OSR1 KINASES
  • ACTIN DYNAMICS
  • GABA ACTIONS
  • RECEPTOR

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