The Role of Adiposity in Cardiometabolic Traits: A Mendelian Randomization Analysis

Tove Fall, Sara Hagg, Reedik Maegi, Alexander Ploner, Krista Fischer, Momoko Horikoshi, Antti-Pekka Sarin, Gudmar Thorleifsson, Claes Ladenvall, Mart Kals, Maris Kuningas, Harmen H. M. Draisma, Janina S. Ried, Natalie R. van Zuydam, Ville Huikari, Massimo Mangino, Emily Sonestedt, Beben Benyamin, Christopher P. Nelson, Natalia V. RiveraKati Kristiansson, Huei-yi Shen, Aki S. Havulinna, Abbas Dehghan, Louise A. Donnelly, Marika Kaakinen, Marja-Liisa Nuotio, Neil Robertson, Renee F. A. G. de Bruijn, M. Arfan Ikram, Najaf Amin, Anthony J. Balmforth, Peter S. Braund, Alexander S. F. Doney, Angela Doering, Paul Elliott, Tonu Esko, Oscar H. Franco, Solveig Gretarsdottir, Anna-Liisa Hartikainen, Kauko Veli Heikkilä, Karl-Heinz Herzig, Hilma Holm, Jouke Jan Hottenga, Elina Hypponen, Johannes Kettunen, Jaakko Kaprio, Tiinamaija Tuomi, Leif Groop, Samuli Ripatti, ENGAGE Consortium

Research output: Contribution to journalArticleScientificpeer-review

Original languageEnglish
JournalPLoS Medicine
Volume10
Issue number6
Pages (from-to)e1001474
Number of pages15
ISSN1549-1676
DOIs
Publication statusPublished - Jun 2013
MoE publication typeA1 Journal article-refereed

Fields of Science

  • BODY-MASS INDEX
  • IMPAIRED GLUCOSE-TOLERANCE
  • GENOME-WIDE ASSOCIATION
  • HEART-FAILURE
  • LIFE-STYLE
  • FTO GENE
  • DIABETES PREVENTION
  • OBESITY
  • RISK
  • DISEASE
  • 3121 Internal medicine

Cite this

Fall, T., Hagg, S., Maegi, R., Ploner, A., Fischer, K., Horikoshi, M., ... ENGAGE Consortium (2013). The Role of Adiposity in Cardiometabolic Traits: A Mendelian Randomization Analysis. PLoS Medicine, 10(6), e1001474. https://doi.org/10.1371/journal.pmed.1001474
Fall, Tove ; Hagg, Sara ; Maegi, Reedik ; Ploner, Alexander ; Fischer, Krista ; Horikoshi, Momoko ; Sarin, Antti-Pekka ; Thorleifsson, Gudmar ; Ladenvall, Claes ; Kals, Mart ; Kuningas, Maris ; Draisma, Harmen H. M. ; Ried, Janina S. ; van Zuydam, Natalie R. ; Huikari, Ville ; Mangino, Massimo ; Sonestedt, Emily ; Benyamin, Beben ; Nelson, Christopher P. ; Rivera, Natalia V. ; Kristiansson, Kati ; Shen, Huei-yi ; Havulinna, Aki S. ; Dehghan, Abbas ; Donnelly, Louise A. ; Kaakinen, Marika ; Nuotio, Marja-Liisa ; Robertson, Neil ; de Bruijn, Renee F. A. G. ; Ikram, M. Arfan ; Amin, Najaf ; Balmforth, Anthony J. ; Braund, Peter S. ; Doney, Alexander S. F. ; Doering, Angela ; Elliott, Paul ; Esko, Tonu ; Franco, Oscar H. ; Gretarsdottir, Solveig ; Hartikainen, Anna-Liisa ; Heikkilä, Kauko Veli ; Herzig, Karl-Heinz ; Holm, Hilma ; Hottenga, Jouke Jan ; Hypponen, Elina ; Kettunen, Johannes ; Kaprio, Jaakko ; Tuomi, Tiinamaija ; Groop, Leif ; Ripatti, Samuli ; ENGAGE Consortium. / The Role of Adiposity in Cardiometabolic Traits: A Mendelian Randomization Analysis. In: PLoS Medicine. 2013 ; Vol. 10, No. 6. pp. e1001474.
@article{4e815279120544e79b9193077cbba322,
title = "The Role of Adiposity in Cardiometabolic Traits: A Mendelian Randomization Analysis",
keywords = "BODY-MASS INDEX, IMPAIRED GLUCOSE-TOLERANCE, GENOME-WIDE ASSOCIATION, HEART-FAILURE, LIFE-STYLE, FTO GENE, DIABETES PREVENTION, OBESITY, RISK, DISEASE, 3121 Internal medicine",
author = "Tove Fall and Sara Hagg and Reedik Maegi and Alexander Ploner and Krista Fischer and Momoko Horikoshi and Antti-Pekka Sarin and Gudmar Thorleifsson and Claes Ladenvall and Mart Kals and Maris Kuningas and Draisma, {Harmen H. M.} and Ried, {Janina S.} and {van Zuydam}, {Natalie R.} and Ville Huikari and Massimo Mangino and Emily Sonestedt and Beben Benyamin and Nelson, {Christopher P.} and Rivera, {Natalia V.} and Kati Kristiansson and Huei-yi Shen and Havulinna, {Aki S.} and Abbas Dehghan and Donnelly, {Louise A.} and Marika Kaakinen and Marja-Liisa Nuotio and Neil Robertson and {de Bruijn}, {Renee F. A. G.} and Ikram, {M. Arfan} and Najaf Amin and Balmforth, {Anthony J.} and Braund, {Peter S.} and Doney, {Alexander S. F.} and Angela Doering and Paul Elliott and Tonu Esko and Franco, {Oscar H.} and Solveig Gretarsdottir and Anna-Liisa Hartikainen and Heikkil{\"a}, {Kauko Veli} and Karl-Heinz Herzig and Hilma Holm and Hottenga, {Jouke Jan} and Elina Hypponen and Johannes Kettunen and Jaakko Kaprio and Tiinamaija Tuomi and Leif Groop and Samuli Ripatti and {ENGAGE Consortium}",
year = "2013",
month = "6",
doi = "10.1371/journal.pmed.1001474",
language = "English",
volume = "10",
pages = "e1001474",
journal = "PLoS Medicine",
issn = "1549-1277",
publisher = "PUBLIC LIBRARY OF SCIENCE",
number = "6",

}

Fall, T, Hagg, S, Maegi, R, Ploner, A, Fischer, K, Horikoshi, M, Sarin, A-P, Thorleifsson, G, Ladenvall, C, Kals, M, Kuningas, M, Draisma, HHM, Ried, JS, van Zuydam, NR, Huikari, V, Mangino, M, Sonestedt, E, Benyamin, B, Nelson, CP, Rivera, NV, Kristiansson, K, Shen, H, Havulinna, AS, Dehghan, A, Donnelly, LA, Kaakinen, M, Nuotio, M-L, Robertson, N, de Bruijn, RFAG, Ikram, MA, Amin, N, Balmforth, AJ, Braund, PS, Doney, ASF, Doering, A, Elliott, P, Esko, T, Franco, OH, Gretarsdottir, S, Hartikainen, A-L, Heikkilä, KV, Herzig, K-H, Holm, H, Hottenga, JJ, Hypponen, E, Kettunen, J, Kaprio, J, Tuomi, T, Groop, L, Ripatti, S & ENGAGE Consortium 2013, 'The Role of Adiposity in Cardiometabolic Traits: A Mendelian Randomization Analysis', PLoS Medicine, vol. 10, no. 6, pp. e1001474. https://doi.org/10.1371/journal.pmed.1001474

The Role of Adiposity in Cardiometabolic Traits: A Mendelian Randomization Analysis. / Fall, Tove; Hagg, Sara; Maegi, Reedik; Ploner, Alexander; Fischer, Krista; Horikoshi, Momoko; Sarin, Antti-Pekka; Thorleifsson, Gudmar; Ladenvall, Claes; Kals, Mart; Kuningas, Maris; Draisma, Harmen H. M.; Ried, Janina S.; van Zuydam, Natalie R.; Huikari, Ville; Mangino, Massimo; Sonestedt, Emily; Benyamin, Beben; Nelson, Christopher P.; Rivera, Natalia V.; Kristiansson, Kati; Shen, Huei-yi; Havulinna, Aki S.; Dehghan, Abbas; Donnelly, Louise A.; Kaakinen, Marika; Nuotio, Marja-Liisa; Robertson, Neil; de Bruijn, Renee F. A. G.; Ikram, M. Arfan; Amin, Najaf; Balmforth, Anthony J.; Braund, Peter S.; Doney, Alexander S. F.; Doering, Angela; Elliott, Paul; Esko, Tonu; Franco, Oscar H.; Gretarsdottir, Solveig; Hartikainen, Anna-Liisa; Heikkilä, Kauko Veli; Herzig, Karl-Heinz; Holm, Hilma; Hottenga, Jouke Jan; Hypponen, Elina; Kettunen, Johannes; Kaprio, Jaakko; Tuomi, Tiinamaija; Groop, Leif; Ripatti, Samuli; ENGAGE Consortium.

In: PLoS Medicine, Vol. 10, No. 6, 06.2013, p. e1001474.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - The Role of Adiposity in Cardiometabolic Traits: A Mendelian Randomization Analysis

AU - Fall, Tove

AU - Hagg, Sara

AU - Maegi, Reedik

AU - Ploner, Alexander

AU - Fischer, Krista

AU - Horikoshi, Momoko

AU - Sarin, Antti-Pekka

AU - Thorleifsson, Gudmar

AU - Ladenvall, Claes

AU - Kals, Mart

AU - Kuningas, Maris

AU - Draisma, Harmen H. M.

AU - Ried, Janina S.

AU - van Zuydam, Natalie R.

AU - Huikari, Ville

AU - Mangino, Massimo

AU - Sonestedt, Emily

AU - Benyamin, Beben

AU - Nelson, Christopher P.

AU - Rivera, Natalia V.

AU - Kristiansson, Kati

AU - Shen, Huei-yi

AU - Havulinna, Aki S.

AU - Dehghan, Abbas

AU - Donnelly, Louise A.

AU - Kaakinen, Marika

AU - Nuotio, Marja-Liisa

AU - Robertson, Neil

AU - de Bruijn, Renee F. A. G.

AU - Ikram, M. Arfan

AU - Amin, Najaf

AU - Balmforth, Anthony J.

AU - Braund, Peter S.

AU - Doney, Alexander S. F.

AU - Doering, Angela

AU - Elliott, Paul

AU - Esko, Tonu

AU - Franco, Oscar H.

AU - Gretarsdottir, Solveig

AU - Hartikainen, Anna-Liisa

AU - Heikkilä, Kauko Veli

AU - Herzig, Karl-Heinz

AU - Holm, Hilma

AU - Hottenga, Jouke Jan

AU - Hypponen, Elina

AU - Kettunen, Johannes

AU - Kaprio, Jaakko

AU - Tuomi, Tiinamaija

AU - Groop, Leif

AU - Ripatti, Samuli

AU - ENGAGE Consortium

PY - 2013/6

Y1 - 2013/6

KW - BODY-MASS INDEX

KW - IMPAIRED GLUCOSE-TOLERANCE

KW - GENOME-WIDE ASSOCIATION

KW - HEART-FAILURE

KW - LIFE-STYLE

KW - FTO GENE

KW - DIABETES PREVENTION

KW - OBESITY

KW - RISK

KW - DISEASE

KW - 3121 Internal medicine

U2 - 10.1371/journal.pmed.1001474

DO - 10.1371/journal.pmed.1001474

M3 - Article

VL - 10

SP - e1001474

JO - PLoS Medicine

JF - PLoS Medicine

SN - 1549-1277

IS - 6

ER -

Fall T, Hagg S, Maegi R, Ploner A, Fischer K, Horikoshi M et al. The Role of Adiposity in Cardiometabolic Traits: A Mendelian Randomization Analysis. PLoS Medicine. 2013 Jun;10(6):e1001474. https://doi.org/10.1371/journal.pmed.1001474