The role of physicochemical properties of entacapone and tolcapone on their efficacy during local intrastriatal administration

M M  Forsberg; M  Huotari; J  Savolainen; P T  Mannisto

doi:10.1016/j.ejps.2005.01.005

The role of physicochemical properties of entacapone and tolcapone on their efficacy during local intrastriatal administration

M M Forsberg
, M Huotari
, J Savolainen
, P T Mannisto

Research output: Contribution to journal › Article › Scientific › peer-review

Original language	English
Journal	European Journal of Pharmaceutical Sciences
Volume	24
Pages (from-to)	503-511
Number of pages	9
ISSN	0928-0987
DOIs	https://doi.org/10.1016/j.ejps.2005.01.005
Publication status	Published - 2005
MoE publication type	A1 Journal article-refereed

Fields of Science

catechol-O-methyltransferase
entacapone
tolcapone
aqueous solubility
apparent partition coefficient
microdialysis
CATECHOL-O-METHYLTRANSFERASE
STRIATAL DOPAMINE METABOLISM
PARKINSONS-DISEASE
COMT INHIBITORS
3-O-METHYLATED METABOLITE
RAT-BRAIN
PHARMACOKINETICS
MICRODIALYSIS
PHARMACODYNAMICS
PHARMACOLOGY
317 Pharmacy

Access to Document

10.1016/j.ejps.2005.01.005

Cite this

@article{1171bc873b5a4d65b2d74eb95cff931e,

title = "The role of physicochemical properties of entacapone and tolcapone on their efficacy during local intrastriatal administration",

keywords = "catechol-O-methyltransferase, entacapone, tolcapone, aqueous solubility, apparent partition coefficient, microdialysis, CATECHOL-O-METHYLTRANSFERASE, STRIATAL DOPAMINE METABOLISM, PARKINSONS-DISEASE, COMT INHIBITORS, 3-O-METHYLATED METABOLITE, RAT-BRAIN, PHARMACOKINETICS, MICRODIALYSIS, PHARMACODYNAMICS, PHARMACOLOGY, 317 Pharmacy",

author = "Forsberg, \{M M\} and M Huotari and J Savolainen and Mannisto, \{P T\}",

year = "2005",

doi = "10.1016/j.ejps.2005.01.005",

language = "English",

volume = "24",

pages = "503--511",

journal = "European Journal of Pharmaceutical Sciences",

issn = "0928-0987",

publisher = "Elsevier B.V.",

}

TY - JOUR

T1 - The role of physicochemical properties of entacapone and tolcapone on their efficacy during local intrastriatal administration

AU - Forsberg, M M

AU - Huotari, M

AU - Savolainen, J

AU - Mannisto, P T

PY - 2005

Y1 - 2005

KW - catechol-O-methyltransferase

KW - entacapone

KW - tolcapone

KW - aqueous solubility

KW - apparent partition coefficient

KW - microdialysis

KW - CATECHOL-O-METHYLTRANSFERASE

KW - STRIATAL DOPAMINE METABOLISM

KW - PARKINSONS-DISEASE

KW - COMT INHIBITORS

KW - 3-O-METHYLATED METABOLITE

KW - RAT-BRAIN

KW - PHARMACOKINETICS

KW - MICRODIALYSIS

KW - PHARMACODYNAMICS

KW - PHARMACOLOGY

KW - 317 Pharmacy

U2 - 10.1016/j.ejps.2005.01.005

DO - 10.1016/j.ejps.2005.01.005

M3 - Article

SN - 0928-0987

VL - 24

SP - 503

EP - 511

JO - European Journal of Pharmaceutical Sciences

JF - European Journal of Pharmaceutical Sciences

ER -