Therapeutic potential and metabolic impact of alternative respiratory chain enzymes

Research output: Chapter in Book/Report/Conference proceedingChapterScientificpeer-review


The alternative enzymes of the respiratory chain, which are found in all the kingdoms of life, except for vertebrates, have received great interest for the treatment of disorders related to mitochondrial dysfunction. These enzymes have recently been used in cellular and animal models to understand and mitigate pathologies from mitochondrial diseases to Parkinson’s disease and cancer. The functional properties of these alternative enzymes have also helped to answer fundamental questions about the role of the respiratory chain in maintaining cellular and tissue metabolism. At the same time, the compatibility of these enzymes with mammalian metabolism has been widely characterized, and rejected on specific occasions. Although many questions remain to be answered regarding the metabolic impact of the alternative enzymes of the respiratory chain in humans, their potential as a therapeutic and research tool is starting to unravel.

Original languageEnglish
Title of host publicationMolecular Nutrition and Mitochondria : Metabolic Deficits, Whole-Diet Interventions, and Targeted Nutraceuticals
EditorsSergej M. Ostojic
Number of pages23
Place of PublicationAmsterdam
Publication date2023
Article number4
ISBN (Print)978-0-323-90256-4
ISBN (Electronic)978-0-323-98452-2
Publication statusPublished - 2023
MoE publication typeA3 Book chapter

Bibliographical note

Publisher Copyright:
© 2023 Elsevier Inc. All rights reserved.

Fields of Science

  • alternative oxidase
  • AOX
  • Metabolism
  • mitochondria
  • mitochondrial disorder
  • NDH2
  • NDI1
  • oxidative phosphorylation
  • oxidative stress
  • respiratory chain
  • 3111 Biomedicine

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