Abstract

Tick-borne encephalitis virus (TBEV) is a growing health concern. It causes a severe disease that can lead to permanent neurological complications or death and the incidence of TBEV infections is constantly rising. Our understanding of TBEV’s structure lags behind that of other flaviviruses, but has advanced recently with the publication of a high-resolution structure of the TBEV virion. The gaps in our knowledge include: aspects of receptor binding, replication and virus assembly. Furthermore, TBEV has mostly been studied in mammalian systems, even though the virus’ interaction with its tick hosts is a central part of its life cycle. Elucidating these aspects of TBEV biology are crucial for the development of TBEV antivirals, as well as the improvement of diagnostics. In this review, we summarise the current structural knowledge on TBEV, bringing attention to the current gaps in our understanding, and propose further research that is needed to truly understand the structural-functional relationship of the virus and its hosts.
Original languageEnglish
Article number350
JournalViruses
Volume10
Issue number7
Number of pages20
ISSN1999-4915
DOIs
Publication statusPublished - 28 Jun 2018
MoE publication typeA2 Review article in a scientific journal

Fields of Science

  • 1183 Plant biology, microbiology, virology
  • tick-borne encephalitis virus
  • TBEV
  • flavivirus structure
  • envelope protein
  • M protein
  • E protein
  • prM
  • nucleocapsid
  • virus assembly
  • maturation
  • WEST-NILE-VIRUS
  • LAMININ-BINDING PROTEIN
  • RECOMBINANT SUBVIRAL PARTICLES
  • FLAVIVIRUS MEMBRANE-FUSION
  • NUCLEOLAR HELICASE DDX56
  • DENGUE VIRUS
  • CAPSID PROTEIN
  • ENVELOPE PROTEIN
  • FEVER VIRUS
  • HEPARAN-SULFATE

Cite this

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title = "Tick-Borne Encephalitis Virus: A Structural View",
abstract = "Tick-borne encephalitis virus (TBEV) is a growing health concern. It causes a severe disease that can lead to permanent neurological complications or death and the incidence of TBEV infections is constantly rising. Our understanding of TBEV’s structure lags behind that of other flaviviruses, but has advanced recently with the publication of a high-resolution structure of the TBEV virion. The gaps in our knowledge include: aspects of receptor binding, replication and virus assembly. Furthermore, TBEV has mostly been studied in mammalian systems, even though the virus’ interaction with its tick hosts is a central part of its life cycle. Elucidating these aspects of TBEV biology are crucial for the development of TBEV antivirals, as well as the improvement of diagnostics. In this review, we summarise the current structural knowledge on TBEV, bringing attention to the current gaps in our understanding, and propose further research that is needed to truly understand the structural-functional relationship of the virus and its hosts.",
keywords = "1183 Plant biology, microbiology, virology, tick-borne encephalitis virus, TBEV, flavivirus structure, envelope protein, M protein, E protein, prM, nucleocapsid, virus assembly, maturation, WEST-NILE-VIRUS, LAMININ-BINDING PROTEIN, RECOMBINANT SUBVIRAL PARTICLES, FLAVIVIRUS MEMBRANE-FUSION, NUCLEOLAR HELICASE DDX56, DENGUE VIRUS, CAPSID PROTEIN, ENVELOPE PROTEIN, FEVER VIRUS, HEPARAN-SULFATE",
author = "Pulkkinen, {Lauri I. A.} and Butcher, {Sarah J.} and Maria Anastasina",
year = "2018",
month = "6",
day = "28",
doi = "10.3390/v10070350",
language = "English",
volume = "10",
journal = "Viruses",
issn = "1999-4915",
publisher = "MDPI",
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}

Tick-Borne Encephalitis Virus: A Structural View. / Pulkkinen, Lauri I. A.; Butcher, Sarah J.; Anastasina, Maria.

In: Viruses, Vol. 10, No. 7, 350, 28.06.2018.

Research output: Contribution to journalReview ArticleScientificpeer-review

TY - JOUR

T1 - Tick-Borne Encephalitis Virus: A Structural View

AU - Pulkkinen, Lauri I. A.

AU - Butcher, Sarah J.

AU - Anastasina, Maria

PY - 2018/6/28

Y1 - 2018/6/28

N2 - Tick-borne encephalitis virus (TBEV) is a growing health concern. It causes a severe disease that can lead to permanent neurological complications or death and the incidence of TBEV infections is constantly rising. Our understanding of TBEV’s structure lags behind that of other flaviviruses, but has advanced recently with the publication of a high-resolution structure of the TBEV virion. The gaps in our knowledge include: aspects of receptor binding, replication and virus assembly. Furthermore, TBEV has mostly been studied in mammalian systems, even though the virus’ interaction with its tick hosts is a central part of its life cycle. Elucidating these aspects of TBEV biology are crucial for the development of TBEV antivirals, as well as the improvement of diagnostics. In this review, we summarise the current structural knowledge on TBEV, bringing attention to the current gaps in our understanding, and propose further research that is needed to truly understand the structural-functional relationship of the virus and its hosts.

AB - Tick-borne encephalitis virus (TBEV) is a growing health concern. It causes a severe disease that can lead to permanent neurological complications or death and the incidence of TBEV infections is constantly rising. Our understanding of TBEV’s structure lags behind that of other flaviviruses, but has advanced recently with the publication of a high-resolution structure of the TBEV virion. The gaps in our knowledge include: aspects of receptor binding, replication and virus assembly. Furthermore, TBEV has mostly been studied in mammalian systems, even though the virus’ interaction with its tick hosts is a central part of its life cycle. Elucidating these aspects of TBEV biology are crucial for the development of TBEV antivirals, as well as the improvement of diagnostics. In this review, we summarise the current structural knowledge on TBEV, bringing attention to the current gaps in our understanding, and propose further research that is needed to truly understand the structural-functional relationship of the virus and its hosts.

KW - 1183 Plant biology, microbiology, virology

KW - tick-borne encephalitis virus

KW - TBEV

KW - flavivirus structure

KW - envelope protein

KW - M protein

KW - E protein

KW - prM

KW - nucleocapsid

KW - virus assembly

KW - maturation

KW - WEST-NILE-VIRUS

KW - LAMININ-BINDING PROTEIN

KW - RECOMBINANT SUBVIRAL PARTICLES

KW - FLAVIVIRUS MEMBRANE-FUSION

KW - NUCLEOLAR HELICASE DDX56

KW - DENGUE VIRUS

KW - CAPSID PROTEIN

KW - ENVELOPE PROTEIN

KW - FEVER VIRUS

KW - HEPARAN-SULFATE

U2 - 10.3390/v10070350

DO - 10.3390/v10070350

M3 - Review Article

VL - 10

JO - Viruses

JF - Viruses

SN - 1999-4915

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ER -