Tofacitinib Suppresses Several JAK-STAT Pathways in Rheumatoid Arthritis In Vivo and Baseline Signaling Profile Associates With Treatment Response

Maaria Palmroth; Krista Kuuliala; Ritva Peltomaa; Anniina Virtanen; Antti Kuuliala; Antti Kurttila; Anna Kinnunen; Marjatta Leirisalo-Repo; Olli Silvennoinen; Pia Isomäki

doi:10.3389/fimmu.2021.738481

Tofacitinib Suppresses Several JAK-STAT Pathways in Rheumatoid Arthritis In Vivo and Baseline Signaling Profile Associates With Treatment Response

Maaria Palmroth, Krista Kuuliala, Ritva Peltomaa, Anniina Virtanen, Antti Kuuliala, Antti Kurttila, Anna Kinnunen, Marjatta Leirisalo-Repo, Olli Silvennoinen, Pia Isomäki

Research output: Contribution to journal › Article › Scientific › peer-review

Original language	English
Article number	738481
Journal	Frontiers in Immunology
Volume	12
Number of pages	12
ISSN	1664-3224
DOIs	https://doi.org/10.3389/fimmu.2021.738481
Publication status	Published - 24 Sept 2021
MoE publication type	A1 Journal article-refereed

Fields of Science

rheumatoid arthritis
cytokines
JAK inhibitor
monocytes
T cells
B cells
JANUS KINASE INHIBITOR
T-CELLS
ACTIVATION
EXPRESSION
INDUCTION
DISCOVERY
CYTOKINES
GENES
ALPHA
SOCS
3121 General medicine, internal medicine and other clinical medicine

Access to Document

10.3389/fimmu.2021.738481

fimmu-12-738481Final published version, 1.02 MBLicence: CC BY

Cite this

Palmroth, M., Kuuliala, K., Peltomaa, R., Virtanen, A., Kuuliala, A., Kurttila, A., Kinnunen, A., Leirisalo-Repo, M., Silvennoinen, O., & Isomäki, P. (2021). Tofacitinib Suppresses Several JAK-STAT Pathways in Rheumatoid Arthritis In Vivo and Baseline Signaling Profile Associates With Treatment Response. Frontiers in Immunology, 12, Article 738481. https://doi.org/10.3389/fimmu.2021.738481

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author = "Maaria Palmroth and Krista Kuuliala and Ritva Peltomaa and Anniina Virtanen and Antti Kuuliala and Antti Kurttila and Anna Kinnunen and Marjatta Leirisalo-Repo and Olli Silvennoinen and Pia Isom{\"a}ki",

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Palmroth, M, Kuuliala, K, Peltomaa, R, Virtanen, A, Kuuliala, A, Kurttila, A, Kinnunen, A, Leirisalo-Repo, M , Silvennoinen, O & Isomäki, P 2021, 'Tofacitinib Suppresses Several JAK-STAT Pathways in Rheumatoid Arthritis In Vivo and Baseline Signaling Profile Associates With Treatment Response', Frontiers in Immunology, vol. 12, 738481. https://doi.org/10.3389/fimmu.2021.738481

TY - JOUR

T1 - Tofacitinib Suppresses Several JAK-STAT Pathways in Rheumatoid Arthritis In Vivo and Baseline Signaling Profile Associates With Treatment Response

AU - Palmroth, Maaria

AU - Kuuliala, Krista

AU - Peltomaa, Ritva

AU - Virtanen, Anniina

AU - Kuuliala, Antti

AU - Kurttila, Antti

AU - Kinnunen, Anna

AU - Leirisalo-Repo, Marjatta

AU - Silvennoinen, Olli

AU - Isomäki, Pia

PY - 2021/9/24

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KW - rheumatoid arthritis

KW - cytokines

KW - JAK inhibitor

KW - monocytes

KW - T cells

KW - B cells

KW - JANUS KINASE INHIBITOR

KW - T-CELLS

KW - ACTIVATION

KW - EXPRESSION

KW - INDUCTION

KW - DISCOVERY

KW - CYTOKINES

KW - GENES

KW - ALPHA

KW - SOCS

KW - 3121 General medicine, internal medicine and other clinical medicine

U2 - 10.3389/fimmu.2021.738481

DO - 10.3389/fimmu.2021.738481

M3 - Article

SN - 1664-3224

VL - 12

JO - Frontiers in Immunology

JF - Frontiers in Immunology

M1 - 738481

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