Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension

Praveen Surendran, Fotios Drenos, Robin Young, Helen Warren, James P. Cook, Alisa K. Manning, Niels Grarup, Xueling Sim, Daniel R. Barnes, Kate Witkowska, James R. Staley, Vinicius Tragante, Taru Tukiainen, Hanieh Yaghootkar, Nicholas Masca, Daniel F. Freitag, Teresa Ferreira, Olga Giannakopoulou, Andrew Tinker, Magdalena Harakalova & 44 others Evelin Mihailov, Chunyu Liu, Aldi T. Kraja, Sune Fallgaard Nielsen, Asif Rasheed, Maria Samue, Wei Zhao, Lori L. Bonnycastle, Anne U. Jackson, Narisu Narisu, Amy J. Swift, Lorraine Southam, Jonathan Marten, Jeroen R. Huyghe, Alena Stancakova, Cristiano Fava, Therese Ohlsson, Angela Matchan, Kathleen E. Stirrups, Jette Bork-Jensen, Anette P. Gjesing, Jukka Kontto, Markus Perola, Susan Shaw-Hawkins, Aki S. Havulinna, Eero Kajantie, Tiinamaija Tuomi, Leif Groop, Aarno Palotie, Samuli Ripatti, CHARGE Heart Failure Consortiumm, EchoGen Consortiumm, Metastroke Consortiumm, Giant Consortiumm, EPIC-InterAct Consortium, Lifelines Cohort Study, Wellcome Trust Case Control Consor, Understanding Soc Sci Grp, EPIC-CVD Consortium, CHARGE Exome Chip Blood Pressure C, T2D-GENES Consortium, GoT2DGenes Consortium, ExomeBP Consortium, CHD Exome Consortium

Research output: Contribution to journalArticleScientificpeer-review

Original languageEnglish
JournalNature Genetics
Volume48
Issue number10
Pages (from-to)1151-1161
Number of pages11
ISSN1061-4036
DOIs
Publication statusPublished - Oct 2016
MoE publication typeA1 Journal article-refereed

Fields of Science

  • GENOME-WIDE ASSOCIATION
  • GENE-CENTRIC ARRAY
  • CARDIOVASCULAR-DISEASE
  • AGING RESEARCH
  • PLASMA-LEVELS
  • RISK-FACTORS
  • LOCI
  • CHARGE
  • HEART
  • IDENTIFICATION
  • 1184 Genetics, developmental biology, physiology
  • 3111 Biomedicine

Cite this

Surendran, P., Drenos, F., Young, R., Warren, H., Cook, J. P., Manning, A. K., ... CHD Exome Consortium (2016). Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension. Nature Genetics, 48(10), 1151-1161. https://doi.org/10.1038/ng.3654
Surendran, Praveen ; Drenos, Fotios ; Young, Robin ; Warren, Helen ; Cook, James P. ; Manning, Alisa K. ; Grarup, Niels ; Sim, Xueling ; Barnes, Daniel R. ; Witkowska, Kate ; Staley, James R. ; Tragante, Vinicius ; Tukiainen, Taru ; Yaghootkar, Hanieh ; Masca, Nicholas ; Freitag, Daniel F. ; Ferreira, Teresa ; Giannakopoulou, Olga ; Tinker, Andrew ; Harakalova, Magdalena ; Mihailov, Evelin ; Liu, Chunyu ; Kraja, Aldi T. ; Nielsen, Sune Fallgaard ; Rasheed, Asif ; Samue, Maria ; Zhao, Wei ; Bonnycastle, Lori L. ; Jackson, Anne U. ; Narisu, Narisu ; Swift, Amy J. ; Southam, Lorraine ; Marten, Jonathan ; Huyghe, Jeroen R. ; Stancakova, Alena ; Fava, Cristiano ; Ohlsson, Therese ; Matchan, Angela ; Stirrups, Kathleen E. ; Bork-Jensen, Jette ; Gjesing, Anette P. ; Kontto, Jukka ; Perola, Markus ; Shaw-Hawkins, Susan ; Havulinna, Aki S. ; Kajantie, Eero ; Tuomi, Tiinamaija ; Groop, Leif ; Palotie, Aarno ; Ripatti, Samuli ; CHARGE Heart Failure Consortiumm ; EchoGen Consortiumm ; Metastroke Consortiumm ; Giant Consortiumm ; EPIC-InterAct Consortium ; Lifelines Cohort Study ; Wellcome Trust Case Control Consor ; Understanding Soc Sci Grp ; EPIC-CVD Consortium ; CHARGE Exome Chip Blood Pressure C ; T2D-GENES Consortium ; GoT2DGenes Consortium ; ExomeBP Consortium ; CHD Exome Consortium. / Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension. In: Nature Genetics. 2016 ; Vol. 48, No. 10. pp. 1151-1161.
@article{77f6ccb0ccd240ab9e8f2b7ae9fad4b6,
title = "Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension",
keywords = "GENOME-WIDE ASSOCIATION, GENE-CENTRIC ARRAY, CARDIOVASCULAR-DISEASE, AGING RESEARCH, PLASMA-LEVELS, RISK-FACTORS, LOCI, CHARGE, HEART, IDENTIFICATION, 1184 Genetics, developmental biology, physiology, 3111 Biomedicine",
author = "Praveen Surendran and Fotios Drenos and Robin Young and Helen Warren and Cook, {James P.} and Manning, {Alisa K.} and Niels Grarup and Xueling Sim and Barnes, {Daniel R.} and Kate Witkowska and Staley, {James R.} and Vinicius Tragante and Taru Tukiainen and Hanieh Yaghootkar and Nicholas Masca and Freitag, {Daniel F.} and Teresa Ferreira and Olga Giannakopoulou and Andrew Tinker and Magdalena Harakalova and Evelin Mihailov and Chunyu Liu and Kraja, {Aldi T.} and Nielsen, {Sune Fallgaard} and Asif Rasheed and Maria Samue and Wei Zhao and Bonnycastle, {Lori L.} and Jackson, {Anne U.} and Narisu Narisu and Swift, {Amy J.} and Lorraine Southam and Jonathan Marten and Huyghe, {Jeroen R.} and Alena Stancakova and Cristiano Fava and Therese Ohlsson and Angela Matchan and Stirrups, {Kathleen E.} and Jette Bork-Jensen and Gjesing, {Anette P.} and Jukka Kontto and Markus Perola and Susan Shaw-Hawkins and Havulinna, {Aki S.} and Eero Kajantie and Tiinamaija Tuomi and Leif Groop and Aarno Palotie and Samuli Ripatti and {CHARGE Heart Failure Consortiumm} and {EchoGen Consortiumm} and {Metastroke Consortiumm} and {Giant Consortiumm} and {EPIC-InterAct Consortium} and {Lifelines Cohort Study} and {Wellcome Trust Case Control Consor} and {Understanding Soc Sci Grp} and {EPIC-CVD Consortium} and {CHARGE Exome Chip Blood Pressure C} and {T2D-GENES Consortium} and {GoT2DGenes Consortium} and {ExomeBP Consortium} and {CHD Exome Consortium}",
year = "2016",
month = "10",
doi = "10.1038/ng.3654",
language = "English",
volume = "48",
pages = "1151--1161",
journal = "Nature Genetics",
issn = "1061-4036",
publisher = "Nature Publishing Group",
number = "10",

}

Surendran, P, Drenos, F, Young, R, Warren, H, Cook, JP, Manning, AK, Grarup, N, Sim, X, Barnes, DR, Witkowska, K, Staley, JR, Tragante, V, Tukiainen, T, Yaghootkar, H, Masca, N, Freitag, DF, Ferreira, T, Giannakopoulou, O, Tinker, A, Harakalova, M, Mihailov, E, Liu, C, Kraja, AT, Nielsen, SF, Rasheed, A, Samue, M, Zhao, W, Bonnycastle, LL, Jackson, AU, Narisu, N, Swift, AJ, Southam, L, Marten, J, Huyghe, JR, Stancakova, A, Fava, C, Ohlsson, T, Matchan, A, Stirrups, KE, Bork-Jensen, J, Gjesing, AP, Kontto, J, Perola, M, Shaw-Hawkins, S, Havulinna, AS, Kajantie, E, Tuomi, T, Groop, L, Palotie, A, Ripatti, S, CHARGE Heart Failure Consortiumm, EchoGen Consortiumm, Metastroke Consortiumm, Giant Consortiumm, EPIC-InterAct Consortium, Lifelines Cohort Study, Wellcome Trust Case Control Consor, Understanding Soc Sci Grp, EPIC-CVD Consortium, CHARGE Exome Chip Blood Pressure C, T2D-GENES Consortium, GoT2DGenes Consortium, ExomeBP Consortium & CHD Exome Consortium 2016, 'Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension', Nature Genetics, vol. 48, no. 10, pp. 1151-1161. https://doi.org/10.1038/ng.3654

Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension. / Surendran, Praveen; Drenos, Fotios; Young, Robin; Warren, Helen; Cook, James P.; Manning, Alisa K.; Grarup, Niels; Sim, Xueling; Barnes, Daniel R.; Witkowska, Kate; Staley, James R.; Tragante, Vinicius; Tukiainen, Taru; Yaghootkar, Hanieh; Masca, Nicholas; Freitag, Daniel F.; Ferreira, Teresa; Giannakopoulou, Olga; Tinker, Andrew; Harakalova, Magdalena; Mihailov, Evelin; Liu, Chunyu; Kraja, Aldi T.; Nielsen, Sune Fallgaard; Rasheed, Asif; Samue, Maria; Zhao, Wei; Bonnycastle, Lori L.; Jackson, Anne U.; Narisu, Narisu; Swift, Amy J.; Southam, Lorraine; Marten, Jonathan; Huyghe, Jeroen R.; Stancakova, Alena; Fava, Cristiano; Ohlsson, Therese; Matchan, Angela; Stirrups, Kathleen E.; Bork-Jensen, Jette; Gjesing, Anette P.; Kontto, Jukka; Perola, Markus; Shaw-Hawkins, Susan; Havulinna, Aki S.; Kajantie, Eero; Tuomi, Tiinamaija; Groop, Leif; Palotie, Aarno; Ripatti, Samuli; CHARGE Heart Failure Consortiumm; EchoGen Consortiumm; Metastroke Consortiumm; Giant Consortiumm; EPIC-InterAct Consortium; Lifelines Cohort Study; Wellcome Trust Case Control Consor; Understanding Soc Sci Grp; EPIC-CVD Consortium; CHARGE Exome Chip Blood Pressure C; T2D-GENES Consortium; GoT2DGenes Consortium; ExomeBP Consortium; CHD Exome Consortium.

In: Nature Genetics, Vol. 48, No. 10, 10.2016, p. 1151-1161.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension

AU - Surendran, Praveen

AU - Drenos, Fotios

AU - Young, Robin

AU - Warren, Helen

AU - Cook, James P.

AU - Manning, Alisa K.

AU - Grarup, Niels

AU - Sim, Xueling

AU - Barnes, Daniel R.

AU - Witkowska, Kate

AU - Staley, James R.

AU - Tragante, Vinicius

AU - Tukiainen, Taru

AU - Yaghootkar, Hanieh

AU - Masca, Nicholas

AU - Freitag, Daniel F.

AU - Ferreira, Teresa

AU - Giannakopoulou, Olga

AU - Tinker, Andrew

AU - Harakalova, Magdalena

AU - Mihailov, Evelin

AU - Liu, Chunyu

AU - Kraja, Aldi T.

AU - Nielsen, Sune Fallgaard

AU - Rasheed, Asif

AU - Samue, Maria

AU - Zhao, Wei

AU - Bonnycastle, Lori L.

AU - Jackson, Anne U.

AU - Narisu, Narisu

AU - Swift, Amy J.

AU - Southam, Lorraine

AU - Marten, Jonathan

AU - Huyghe, Jeroen R.

AU - Stancakova, Alena

AU - Fava, Cristiano

AU - Ohlsson, Therese

AU - Matchan, Angela

AU - Stirrups, Kathleen E.

AU - Bork-Jensen, Jette

AU - Gjesing, Anette P.

AU - Kontto, Jukka

AU - Perola, Markus

AU - Shaw-Hawkins, Susan

AU - Havulinna, Aki S.

AU - Kajantie, Eero

AU - Tuomi, Tiinamaija

AU - Groop, Leif

AU - Palotie, Aarno

AU - Ripatti, Samuli

AU - CHARGE Heart Failure Consortiumm

AU - EchoGen Consortiumm

AU - Metastroke Consortiumm

AU - Giant Consortiumm

AU - EPIC-InterAct Consortium

AU - Lifelines Cohort Study

AU - Wellcome Trust Case Control Consor

AU - Understanding Soc Sci Grp

AU - EPIC-CVD Consortium

AU - CHARGE Exome Chip Blood Pressure C

AU - T2D-GENES Consortium

AU - GoT2DGenes Consortium

AU - ExomeBP Consortium

AU - CHD Exome Consortium

PY - 2016/10

Y1 - 2016/10

KW - GENOME-WIDE ASSOCIATION

KW - GENE-CENTRIC ARRAY

KW - CARDIOVASCULAR-DISEASE

KW - AGING RESEARCH

KW - PLASMA-LEVELS

KW - RISK-FACTORS

KW - LOCI

KW - CHARGE

KW - HEART

KW - IDENTIFICATION

KW - 1184 Genetics, developmental biology, physiology

KW - 3111 Biomedicine

U2 - 10.1038/ng.3654

DO - 10.1038/ng.3654

M3 - Article

VL - 48

SP - 1151

EP - 1161

JO - Nature Genetics

JF - Nature Genetics

SN - 1061-4036

IS - 10

ER -