Transfer RNA modification and infection – implications for pathogenicity and host responses

Research output: Contribution to journalReview ArticleScientificpeer-review

Abstract

Transfer RNA (tRNA) molecules are sumptuously decorated with evolutionary conserved post-transcriptional nucleoside modifications that are essential for structural stability and ensure efficient protein translation. The tRNA modification levels change significantly in response to physiological stresses, altering translation in a number of ways. For instance, tRNA hypomodification leads to translational slowdown, disrupting protein homeostasis and reducing cellular fitness. This highlights the importance of proper tRNA modification as a determinant for maintaining cellular function and viability during stress. Furthermore, the expression of several microbial virulence factors is induced by changes in environmental conditions; a process where tRNA 2-thiolation is unequivocal for pathogenicity. In this review, we discuss the multifaceted implications of tRNA modification for infection by examining the roles of nucleoside modification in tRNA biology. Future development of novel methods and combinatory utilization of existing technologies will bring tRNA modification-mediated regulation of cellular immunity and pathogenicity to the limelight.
Original languageEnglish
JournalBiochimica et Biophysica Acta. Gene Regulatory Mechanisms
Volume1861
Issue number4
Pages (from-to)419-432
ISSN1874-9399
DOIs
Publication statusPublished - Apr 2018
MoE publication typeA2 Review article in a scientific journal

Bibliographical note

Open Access funded by the author(s).

Fields of Science

  • 1182 Biochemistry, cell and molecular biology
  • TRANSLATION
  • transfer RNA
  • post-transcriptional modification
  • 1183 Plant biology, microbiology, virology
  • Host-pathogen interaction
  • INFECTION

Cite this

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title = "Transfer RNA modification and infection – implications for pathogenicity and host responses",
abstract = "Transfer RNA (tRNA) molecules are sumptuously decorated with evolutionary conserved post-transcriptional nucleoside modifications that are essential for structural stability and ensure efficient protein translation. The tRNA modification levels change significantly in response to physiological stresses, altering translation in a number of ways. For instance, tRNA hypomodification leads to translational slowdown, disrupting protein homeostasis and reducing cellular fitness. This highlights the importance of proper tRNA modification as a determinant for maintaining cellular function and viability during stress. Furthermore, the expression of several microbial virulence factors is induced by changes in environmental conditions; a process where tRNA 2-thiolation is unequivocal for pathogenicity. In this review, we discuss the multifaceted implications of tRNA modification for infection by examining the roles of nucleoside modification in tRNA biology. Future development of novel methods and combinatory utilization of existing technologies will bring tRNA modification-mediated regulation of cellular immunity and pathogenicity to the limelight.",
keywords = "1182 Biochemistry, cell and molecular biology, TRANSLATION, transfer RNA, post-transcriptional modification, 1183 Plant biology, microbiology, virology, Host-pathogen interaction, INFECTION",
author = "Koh, {Cha San} and Sarin, {Leif Peter}",
note = "Open Access funded by the author(s).",
year = "2018",
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doi = "10.1016/j.bbagrm.2018.01.015",
language = "English",
volume = "1861",
pages = "419--432",
journal = "Biochimica et Biophysica Acta. Gene Regulatory Mechanisms",
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}

Transfer RNA modification and infection – implications for pathogenicity and host responses. / Koh, Cha San; Sarin, Leif Peter.

In: Biochimica et Biophysica Acta. Gene Regulatory Mechanisms, Vol. 1861, No. 4, 04.2018, p. 419-432.

Research output: Contribution to journalReview ArticleScientificpeer-review

TY - JOUR

T1 - Transfer RNA modification and infection – implications for pathogenicity and host responses

AU - Koh, Cha San

AU - Sarin, Leif Peter

N1 - Open Access funded by the author(s).

PY - 2018/4

Y1 - 2018/4

N2 - Transfer RNA (tRNA) molecules are sumptuously decorated with evolutionary conserved post-transcriptional nucleoside modifications that are essential for structural stability and ensure efficient protein translation. The tRNA modification levels change significantly in response to physiological stresses, altering translation in a number of ways. For instance, tRNA hypomodification leads to translational slowdown, disrupting protein homeostasis and reducing cellular fitness. This highlights the importance of proper tRNA modification as a determinant for maintaining cellular function and viability during stress. Furthermore, the expression of several microbial virulence factors is induced by changes in environmental conditions; a process where tRNA 2-thiolation is unequivocal for pathogenicity. In this review, we discuss the multifaceted implications of tRNA modification for infection by examining the roles of nucleoside modification in tRNA biology. Future development of novel methods and combinatory utilization of existing technologies will bring tRNA modification-mediated regulation of cellular immunity and pathogenicity to the limelight.

AB - Transfer RNA (tRNA) molecules are sumptuously decorated with evolutionary conserved post-transcriptional nucleoside modifications that are essential for structural stability and ensure efficient protein translation. The tRNA modification levels change significantly in response to physiological stresses, altering translation in a number of ways. For instance, tRNA hypomodification leads to translational slowdown, disrupting protein homeostasis and reducing cellular fitness. This highlights the importance of proper tRNA modification as a determinant for maintaining cellular function and viability during stress. Furthermore, the expression of several microbial virulence factors is induced by changes in environmental conditions; a process where tRNA 2-thiolation is unequivocal for pathogenicity. In this review, we discuss the multifaceted implications of tRNA modification for infection by examining the roles of nucleoside modification in tRNA biology. Future development of novel methods and combinatory utilization of existing technologies will bring tRNA modification-mediated regulation of cellular immunity and pathogenicity to the limelight.

KW - 1182 Biochemistry, cell and molecular biology

KW - TRANSLATION

KW - transfer RNA

KW - post-transcriptional modification

KW - 1183 Plant biology, microbiology, virology

KW - Host-pathogen interaction

KW - INFECTION

U2 - 10.1016/j.bbagrm.2018.01.015

DO - 10.1016/j.bbagrm.2018.01.015

M3 - Review Article

VL - 1861

SP - 419

EP - 432

JO - Biochimica et Biophysica Acta. Gene Regulatory Mechanisms

JF - Biochimica et Biophysica Acta. Gene Regulatory Mechanisms

SN - 1874-9399

IS - 4

ER -