Treatment-induced painful diabetic neuropathy

Milla Rosengård-Bärlund, Hanna Harno

Research output: Chapter in Book/Report/Conference proceedingChapterScientificpeer-review


Treatment-induced neuropathy of diabetes (TIND) is a form of painful sensory and autonomic diabetic neuropathy that manifests after rapid improvement of glycemic control in individuals with previously inadequately controlled diabetes. This form of diabetic neuropathy can occur in any type of diabetes treated with insulin, injectable GLP-1 agonists, oral antidiabetic drugs, or even diet control. Acute or subacute neuropathic pain occurs secondary to the change in glucose control and is frequently accompanied by autonomic dysfunction. Moreover, an increased risk of deterioration of retinopathy or nephropathy has been reported. Although the prevalence of TIND is unknown, it is probably also underreported. It differs from typical diabetic neuropathy by its reversibility, at least in patients who later have stable glycemic control. In addition to glycemic control, supportive care and neuropathic pain treatment are the only treatments available for TIND. Neuropathic pain is ultimately resolved in most patients, but often only after 1-2 years. Future research is needed to characterize the natural history and underlying mechanisms of TIND and to prevent this neuropathy and provide treatment recommendations for it.

Original languageEnglish
Title of host publicationDiabetic Neuropathy
Number of pages10
Publication date1 Jan 2022
ISBN (Print)9780128206706
ISBN (Electronic)9780128206690
Publication statusPublished - 1 Jan 2022
MoE publication typeA3 Book chapter

Bibliographical note

Publisher Copyright:
© 2022 Elsevier Inc. All rights reserved.

Fields of Science

  • Diabetic neuropathy
  • Small-fiber neuropathy
  • TIND
  • Treatment-induced neuropathy
  • 3112 Neurosciences
  • 3124 Neurology and psychiatry
  • 3121 General medicine, internal medicine and other clinical medicine

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