Trophic factors

Neurotrophic factors

Research output: Chapter in Book/Report/Conference proceedingChapterScientificpeer-review

Abstract

Neurotrophic factors support survival, process outgrowth, and phenotypic differentiation of neurons during development. Many neurotrophic factors are also expressed in adult brain, where they regulate neuronal connectivity and network plasticity. Neurotrophic factors are typically released from the target cells or postsynaptic neurons, taken up by the presynaptic axon terminals and retrogradely transported to the soma. Access of the axon terminal to neurotrophic factors selects among excessively generated neurons or neuronal processes for survival those that have established an optimal connection with the target cell, whereas neurons or processes with an insufficient access or transport of neurotrophic factors degenerate. Therefore, the primary function of neurotrophic factors is to mediate information to the neuronal soma about the quality of the connection between a neuron and its target. © Springer Science+Business Media, LLC 2013 and Springer Science+Business Media New York 2016.
Original languageEnglish
Title of host publicationNeuroscience in the 21st Century : From Basic to Clinical
EditorsDonald Plaff, Nora Volkov
PublisherSPRINGER NEW YORK LLC
Publication date2016
Edition2nd
Pages1843-1876
ISBN (Electronic)9781493934744
DOIs
Publication statusPublished - 2016
MoE publication typeA3 Book chapter

Bibliographical note

cited By 0

Fields of Science

  • 3112 Neurosciences

Cite this

Castrén, E. (2016). Trophic factors: Neurotrophic factors. In D. Plaff, & N. Volkov (Eds.), Neuroscience in the 21st Century: From Basic to Clinical (2nd ed., pp. 1843-1876). SPRINGER NEW YORK LLC. https://doi.org/10.1007/978-1-4939-3474-4_55
Castrén, E. / Trophic factors : Neurotrophic factors. Neuroscience in the 21st Century: From Basic to Clinical. editor / Donald Plaff ; Nora Volkov. 2nd. ed. SPRINGER NEW YORK LLC, 2016. pp. 1843-1876
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Castrén, E 2016, Trophic factors: Neurotrophic factors. in D Plaff & N Volkov (eds), Neuroscience in the 21st Century: From Basic to Clinical. 2nd edn, SPRINGER NEW YORK LLC, pp. 1843-1876. https://doi.org/10.1007/978-1-4939-3474-4_55

Trophic factors : Neurotrophic factors. / Castrén, E.

Neuroscience in the 21st Century: From Basic to Clinical. ed. / Donald Plaff; Nora Volkov. 2nd. ed. SPRINGER NEW YORK LLC, 2016. p. 1843-1876.

Research output: Chapter in Book/Report/Conference proceedingChapterScientificpeer-review

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AB - Neurotrophic factors support survival, process outgrowth, and phenotypic differentiation of neurons during development. Many neurotrophic factors are also expressed in adult brain, where they regulate neuronal connectivity and network plasticity. Neurotrophic factors are typically released from the target cells or postsynaptic neurons, taken up by the presynaptic axon terminals and retrogradely transported to the soma. Access of the axon terminal to neurotrophic factors selects among excessively generated neurons or neuronal processes for survival those that have established an optimal connection with the target cell, whereas neurons or processes with an insufficient access or transport of neurotrophic factors degenerate. Therefore, the primary function of neurotrophic factors is to mediate information to the neuronal soma about the quality of the connection between a neuron and its target. © Springer Science+Business Media, LLC 2013 and Springer Science+Business Media New York 2016.

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PB - SPRINGER NEW YORK LLC

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Castrén E. Trophic factors: Neurotrophic factors. In Plaff D, Volkov N, editors, Neuroscience in the 21st Century: From Basic to Clinical. 2nd ed. SPRINGER NEW YORK LLC. 2016. p. 1843-1876 https://doi.org/10.1007/978-1-4939-3474-4_55