UDP-Glucuronosyltransferase (UGT) Polymorphisms Affect Atorvastatin Lactonization In Vitro and In Vivo

S. Riedmaier, K. Klein, U. Hofmann, Jenni Eliisa Keskitalo, Pertti Jaakko Neuvonen, M. Schwab, Mikko Olavi Niemi, U. M. Zanger

Research output: Contribution to journalArticleScientificpeer-review

Original languageEnglish
JournalClinical Pharmacology and Therapeutics
Volume87
Issue number1
Pages (from-to)65-73
Number of pages9
ISSN0009-9236
DOIs
Publication statusPublished - 2010
MoE publication typeA1 Journal article-refereed

Fields of Science

  • HMG-COA REDUCTASE
  • HUMAN LIVER-MICROSOMES
  • LACTONE FORMS
  • SLCO1B1 POLYMORPHISM
  • DRUG-INTERACTIONS
  • MARKEDLY AFFECTS
  • INDUCED MYOPATHY
  • ACID
  • GLUCURONIDATION
  • PHARMACOKINETICS
  • 312 Clinical medicine

Cite this

Riedmaier, S. ; Klein, K. ; Hofmann, U. ; Keskitalo, Jenni Eliisa ; Neuvonen, Pertti Jaakko ; Schwab, M. ; Niemi, Mikko Olavi ; Zanger, U. M. / UDP-Glucuronosyltransferase (UGT) Polymorphisms Affect Atorvastatin Lactonization In Vitro and In Vivo. In: Clinical Pharmacology and Therapeutics. 2010 ; Vol. 87, No. 1. pp. 65-73.
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title = "UDP-Glucuronosyltransferase (UGT) Polymorphisms Affect Atorvastatin Lactonization In Vitro and In Vivo",
keywords = "HMG-COA REDUCTASE, HUMAN LIVER-MICROSOMES, LACTONE FORMS, SLCO1B1 POLYMORPHISM, DRUG-INTERACTIONS, MARKEDLY AFFECTS, INDUCED MYOPATHY, ACID, GLUCURONIDATION, PHARMACOKINETICS, 312 Clinical medicine",
author = "S. Riedmaier and K. Klein and U. Hofmann and Keskitalo, {Jenni Eliisa} and Neuvonen, {Pertti Jaakko} and M. Schwab and Niemi, {Mikko Olavi} and Zanger, {U. M.}",
year = "2010",
doi = "10.1038/clpt.2009.181",
language = "English",
volume = "87",
pages = "65--73",
journal = "Clinical Pharmacology and Therapeutics",
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UDP-Glucuronosyltransferase (UGT) Polymorphisms Affect Atorvastatin Lactonization In Vitro and In Vivo. / Riedmaier, S.; Klein, K.; Hofmann, U.; Keskitalo, Jenni Eliisa; Neuvonen, Pertti Jaakko; Schwab, M.; Niemi, Mikko Olavi; Zanger, U. M.

In: Clinical Pharmacology and Therapeutics, Vol. 87, No. 1, 2010, p. 65-73.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - UDP-Glucuronosyltransferase (UGT) Polymorphisms Affect Atorvastatin Lactonization In Vitro and In Vivo

AU - Riedmaier, S.

AU - Klein, K.

AU - Hofmann, U.

AU - Keskitalo, Jenni Eliisa

AU - Neuvonen, Pertti Jaakko

AU - Schwab, M.

AU - Niemi, Mikko Olavi

AU - Zanger, U. M.

PY - 2010

Y1 - 2010

KW - HMG-COA REDUCTASE

KW - HUMAN LIVER-MICROSOMES

KW - LACTONE FORMS

KW - SLCO1B1 POLYMORPHISM

KW - DRUG-INTERACTIONS

KW - MARKEDLY AFFECTS

KW - INDUCED MYOPATHY

KW - ACID

KW - GLUCURONIDATION

KW - PHARMACOKINETICS

KW - 312 Clinical medicine

U2 - 10.1038/clpt.2009.181

DO - 10.1038/clpt.2009.181

M3 - Article

VL - 87

SP - 65

EP - 73

JO - Clinical Pharmacology and Therapeutics

JF - Clinical Pharmacology and Therapeutics

SN - 0009-9236

IS - 1

ER -