UGT1A10 Is a High Activity and Important Extrahepatic Enzyme

Why Has Its Role in Intestinal Glucuronidation Been Frequently Underestimated?

Johanna Troberg, Erkka Järvinen, Guang-Bo Ge, Ling Yang, Moshe Finel

Research output: Contribution to journalArticleScientificpeer-review

Original languageEnglish
JournalMolecular Pharmaceutics
Volume14
Issue number9
Pages (from-to)2875-2883
Number of pages9
ISSN1543-8384
DOIs
Publication statusPublished - Sep 2017
MoE publication typeA1 Journal article-refereed

Fields of Science

  • UDP-glucuronosyltransferase
  • recombinant UGT1A10
  • intestine microsomes
  • intestinal glucuronidation
  • estradiol
  • estrone
  • morphine
  • SN-38
  • AMC
  • NCHN
  • bavachinin
  • HUMAN UDP-GLUCURONOSYLTRANSFERASES
  • TANDEM MASS-SPECTROMETRY
  • TRANSFERASE 1A
  • HUMAN TISSUES
  • UGT ENZYMES
  • IN-VITRO
  • EXPRESSION
  • ISOFORMS
  • QUANTIFICATION
  • SELECTIVITY
  • 317 Pharmacy

Cite this

@article{0cb6ee10ab1e487ebafc916671437f05,
title = "UGT1A10 Is a High Activity and Important Extrahepatic Enzyme: Why Has Its Role in Intestinal Glucuronidation Been Frequently Underestimated?",
keywords = "UDP-glucuronosyltransferase, recombinant UGT1A10, intestine microsomes, intestinal glucuronidation, estradiol, estrone, morphine, SN-38, AMC, NCHN, bavachinin, HUMAN UDP-GLUCURONOSYLTRANSFERASES, TANDEM MASS-SPECTROMETRY, TRANSFERASE 1A, HUMAN TISSUES, UGT ENZYMES, IN-VITRO, EXPRESSION, ISOFORMS, QUANTIFICATION, SELECTIVITY, 317 Pharmacy",
author = "Johanna Troberg and Erkka J{\"a}rvinen and Guang-Bo Ge and Ling Yang and Moshe Finel",
year = "2017",
month = "9",
doi = "10.1021/acs.molpharmaceut.6b00852",
language = "English",
volume = "14",
pages = "2875--2883",
journal = "Molecular Pharmaceutics",
issn = "1543-8384",
publisher = "American Chemical Society",
number = "9",

}

UGT1A10 Is a High Activity and Important Extrahepatic Enzyme : Why Has Its Role in Intestinal Glucuronidation Been Frequently Underestimated? / Troberg, Johanna; Järvinen, Erkka; Ge, Guang-Bo; Yang, Ling; Finel, Moshe.

In: Molecular Pharmaceutics, Vol. 14, No. 9, 09.2017, p. 2875-2883.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - UGT1A10 Is a High Activity and Important Extrahepatic Enzyme

T2 - Why Has Its Role in Intestinal Glucuronidation Been Frequently Underestimated?

AU - Troberg, Johanna

AU - Järvinen, Erkka

AU - Ge, Guang-Bo

AU - Yang, Ling

AU - Finel, Moshe

PY - 2017/9

Y1 - 2017/9

KW - UDP-glucuronosyltransferase

KW - recombinant UGT1A10

KW - intestine microsomes

KW - intestinal glucuronidation

KW - estradiol

KW - estrone

KW - morphine

KW - SN-38

KW - AMC

KW - NCHN

KW - bavachinin

KW - HUMAN UDP-GLUCURONOSYLTRANSFERASES

KW - TANDEM MASS-SPECTROMETRY

KW - TRANSFERASE 1A

KW - HUMAN TISSUES

KW - UGT ENZYMES

KW - IN-VITRO

KW - EXPRESSION

KW - ISOFORMS

KW - QUANTIFICATION

KW - SELECTIVITY

KW - 317 Pharmacy

U2 - 10.1021/acs.molpharmaceut.6b00852

DO - 10.1021/acs.molpharmaceut.6b00852

M3 - Article

VL - 14

SP - 2875

EP - 2883

JO - Molecular Pharmaceutics

JF - Molecular Pharmaceutics

SN - 1543-8384

IS - 9

ER -