Ultrasound-based surface sampling in immersion for mass spectrometry

Tom Sillanpää; Jere Hyvönen; Joni Mäkinen; Axi Holmström; Topi Pudas; Petri  Lassila; Riikka Lepistö; Antti Kuronen; Tapio Kotiaho; Edward Haeggström; Ari Salmi

doi:10.1063/5.0157705

Ultrasound-based surface sampling in immersion for mass spectrometry

Tom Sillanpää, Jere Hyvönen, Joni Mäkinen, Axi Holmström, Topi Pudas, Petri Lassila, Riikka Lepistö, Antti Kuronen, Tapio Kotiaho, Edward Haeggström, Ari Salmi

Research output: Contribution to journal › Article › Scientific › peer-review

Abstract

We present a surface sampling method for the chemical analysis of liquid-immersed solid samples. Liquid immersion allows samples to be kept in a hydrated state. We employed cavitation generated by high-intensity focused ultrasound for localized material removal. The appropriate transducer–sample distance was determined using the actuating ultrasound transducer prior to sampling, allowing sonication in focus despite surface height variation. We demonstrate the proposed surface sampling method on water-submerged glass cover slides painted with permanent markers, achieving sampling with tunable spot size down to 500 μm. The removed and collected material was transferred for chemical analysis by electrospray ionization mass spectrometry, which showed mass peaks characteristic to the permanent markers.

Original language	English
Article number	104901
Journal	Journal of Applied Physics
Volume	134
Issue number	10
Number of pages	13
ISSN	0021-8979
DOIs	https://doi.org/10.1063/5.0157705
Publication status	Published - 14 Sept 2023
MoE publication type	A1 Journal article-refereed

Fields of Science

114 Physical sciences
Electrospray-ionization
Atmospheric-pressure
Liquid extraction
Cavitation
Chromatography
Sediment
Clouds
Tissue

Access to Document

10.1063/5.0157705

JAP23-MD-01788Accepted author manuscript, 3.38 MBLicence: Unspecified

Cite this

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abstract = "We present a surface sampling method for the chemical analysis of liquid-immersed solid samples. Liquid immersion allows samples to be kept in a hydrated state. We employed cavitation generated by high-intensity focused ultrasound for localized material removal. The appropriate transducer–sample distance was determined using the actuating ultrasound transducer prior to sampling, allowing sonication in focus despite surface height variation. We demonstrate the proposed surface sampling method on water-submerged glass cover slides painted with permanent markers, achieving sampling with tunable spot size down to 500 μm. The removed and collected material was transferred for chemical analysis by electrospray ionization mass spectrometry, which showed mass peaks characteristic to the permanent markers.",

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AU - Sillanpää, Tom

AU - Hyvönen, Jere

AU - Mäkinen, Joni

AU - Holmström, Axi

AU - Pudas, Topi

AU - Lassila, Petri

AU - Lepistö, Riikka

AU - Kuronen, Antti

AU - Kotiaho, Tapio

AU - Haeggström, Edward

AU - Salmi, Ari

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KW - 114 Physical sciences

KW - Electrospray-ionization

KW - Atmospheric-pressure

KW - Liquid extraction

KW - Cavitation

KW - Chromatography

KW - Sediment

KW - Clouds

KW - Tissue

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