USAXS and SAXS from cancer-bearing breast tissue samples

Manuel Fernandez, Heikki Suhonen, Jani Keyriläinen, Alberto Bravin, Stefan Fiedler, Marja-Liisa Karjalainen-Lindsberg, Marjut Leidenius, Karl von Smitten, Pekka Suortti

    Research output: Contribution to journalArticleScientificpeer-review

    Abstract

    "USAXS and SAXS patterns from cancer-bearing human breast tissue samples were recorded at beamline ID02 of the ESRF using a Bonse-Hart camera and a pinhole camera. The samples were classified as being ductal carcinoma, grade 11, and ductal carcinoma in situ, partly invasive. The samples included areas of healthy collagen, invaded collagen, necrotic ducts with calcifications, and adipose tissue. The scattering patterns were analyzed in different ways to separate the scattering contribution and the direct beam from the observed rocking curve (RC) of the analyzer. It was found that USAXS from all tissues was weak, and the effects on the analyzer RC were observed only in the low-intensity tails of the patterns. The intrinsic RC was convolved with different model functions for the impulse response of the sample, and the best fit with experiment was obtained by the Pearson VII function. Significantly different distributions for the Pearson exponent in were obtained in benign and malignant regions of the samples. For a comparison with analyzer-based imaging (ABI) or diffraction enhanced imaging (DEI) a ""long-slit"" integration of the patterns was performed, and this emphasized the scattering contribution in the tails of the rocking Curve. (C) 2008 Elsevier Ireland Ltd. All rights reserved."
    Original languageEnglish
    JournalEuropean Journal of Radiology
    Volume68S
    Pages (from-to)S89-S94
    ISSN0720-048X
    DOIs
    Publication statusPublished - 2008
    MoE publication typeA1 Journal article-refereed

    Cite this

    Fernandez, Manuel ; Suhonen, Heikki ; Keyriläinen, Jani ; Bravin, Alberto ; Fiedler, Stefan ; Karjalainen-Lindsberg, Marja-Liisa ; Leidenius, Marjut ; Smitten, Karl von ; Suortti, Pekka. / USAXS and SAXS from cancer-bearing breast tissue samples. In: European Journal of Radiology. 2008 ; Vol. 68S. pp. S89-S94.
    @article{b08669466c51490bb9610436d9eb1900,
    title = "USAXS and SAXS from cancer-bearing breast tissue samples",
    abstract = "{"}USAXS and SAXS patterns from cancer-bearing human breast tissue samples were recorded at beamline ID02 of the ESRF using a Bonse-Hart camera and a pinhole camera. The samples were classified as being ductal carcinoma, grade 11, and ductal carcinoma in situ, partly invasive. The samples included areas of healthy collagen, invaded collagen, necrotic ducts with calcifications, and adipose tissue. The scattering patterns were analyzed in different ways to separate the scattering contribution and the direct beam from the observed rocking curve (RC) of the analyzer. It was found that USAXS from all tissues was weak, and the effects on the analyzer RC were observed only in the low-intensity tails of the patterns. The intrinsic RC was convolved with different model functions for the impulse response of the sample, and the best fit with experiment was obtained by the Pearson VII function. Significantly different distributions for the Pearson exponent in were obtained in benign and malignant regions of the samples. For a comparison with analyzer-based imaging (ABI) or diffraction enhanced imaging (DEI) a {"}{"}long-slit{"}{"} integration of the patterns was performed, and this emphasized the scattering contribution in the tails of the rocking Curve. (C) 2008 Elsevier Ireland Ltd. All rights reserved.{"}",
    author = "Manuel Fernandez and Heikki Suhonen and Jani Keyril{\"a}inen and Alberto Bravin and Stefan Fiedler and Marja-Liisa Karjalainen-Lindsberg and Marjut Leidenius and Smitten, {Karl von} and Pekka Suortti",
    year = "2008",
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    language = "English",
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    USAXS and SAXS from cancer-bearing breast tissue samples. / Fernandez, Manuel; Suhonen, Heikki; Keyriläinen, Jani; Bravin, Alberto; Fiedler, Stefan; Karjalainen-Lindsberg, Marja-Liisa; Leidenius, Marjut; Smitten, Karl von; Suortti, Pekka.

    In: European Journal of Radiology, Vol. 68S, 2008, p. S89-S94.

    Research output: Contribution to journalArticleScientificpeer-review

    TY - JOUR

    T1 - USAXS and SAXS from cancer-bearing breast tissue samples

    AU - Fernandez, Manuel

    AU - Suhonen, Heikki

    AU - Keyriläinen, Jani

    AU - Bravin, Alberto

    AU - Fiedler, Stefan

    AU - Karjalainen-Lindsberg, Marja-Liisa

    AU - Leidenius, Marjut

    AU - Smitten, Karl von

    AU - Suortti, Pekka

    PY - 2008

    Y1 - 2008

    N2 - "USAXS and SAXS patterns from cancer-bearing human breast tissue samples were recorded at beamline ID02 of the ESRF using a Bonse-Hart camera and a pinhole camera. The samples were classified as being ductal carcinoma, grade 11, and ductal carcinoma in situ, partly invasive. The samples included areas of healthy collagen, invaded collagen, necrotic ducts with calcifications, and adipose tissue. The scattering patterns were analyzed in different ways to separate the scattering contribution and the direct beam from the observed rocking curve (RC) of the analyzer. It was found that USAXS from all tissues was weak, and the effects on the analyzer RC were observed only in the low-intensity tails of the patterns. The intrinsic RC was convolved with different model functions for the impulse response of the sample, and the best fit with experiment was obtained by the Pearson VII function. Significantly different distributions for the Pearson exponent in were obtained in benign and malignant regions of the samples. For a comparison with analyzer-based imaging (ABI) or diffraction enhanced imaging (DEI) a ""long-slit"" integration of the patterns was performed, and this emphasized the scattering contribution in the tails of the rocking Curve. (C) 2008 Elsevier Ireland Ltd. All rights reserved."

    AB - "USAXS and SAXS patterns from cancer-bearing human breast tissue samples were recorded at beamline ID02 of the ESRF using a Bonse-Hart camera and a pinhole camera. The samples were classified as being ductal carcinoma, grade 11, and ductal carcinoma in situ, partly invasive. The samples included areas of healthy collagen, invaded collagen, necrotic ducts with calcifications, and adipose tissue. The scattering patterns were analyzed in different ways to separate the scattering contribution and the direct beam from the observed rocking curve (RC) of the analyzer. It was found that USAXS from all tissues was weak, and the effects on the analyzer RC were observed only in the low-intensity tails of the patterns. The intrinsic RC was convolved with different model functions for the impulse response of the sample, and the best fit with experiment was obtained by the Pearson VII function. Significantly different distributions for the Pearson exponent in were obtained in benign and malignant regions of the samples. For a comparison with analyzer-based imaging (ABI) or diffraction enhanced imaging (DEI) a ""long-slit"" integration of the patterns was performed, and this emphasized the scattering contribution in the tails of the rocking Curve. (C) 2008 Elsevier Ireland Ltd. All rights reserved."

    U2 - 10.1016/j.ejrad.2008.04.039

    DO - 10.1016/j.ejrad.2008.04.039

    M3 - Article

    VL - 68S

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    JO - European Journal of Radiology

    JF - European Journal of Radiology

    SN - 0720-048X

    ER -