USF1 deficiency alleviates inflammation, enhances cholesterol efflux and prevents cholesterol accumulation in macrophages

Maija Ruuth; Jarkko Soronen; Essi Kaiharju; Krista Merikanto; Julia Perttilä; Jari Metso; Miriam Lee-Rueckert; Marja-Riitta Taskinen; Petri T. Kovanen; Katariina Öörni; Vesa M. Olkkonen; Matti S. Jauhiainen; Pirkka-Pekka Laurila

doi:10.1186/s12944-018-0930-2

USF1 deficiency alleviates inflammation, enhances cholesterol efflux and prevents cholesterol accumulation in macrophages

Maija Ruuth, Jarkko Soronen, Essi Kaiharju, Krista Merikanto, Julia Perttilä, Jari Metso, Miriam Lee-Rueckert, Marja-Riitta Taskinen, Petri T. Kovanen, Katariina Öörni, Vesa M. Olkkonen, Matti S. Jauhiainen, Pirkka-Pekka Laurila

Research output: Contribution to journal › Article › Scientific › peer-review

Original language	English
Article number	285
Journal	Lipids in Health and Disease
Volume	17
Number of pages	11
ISSN	1476-511X
DOIs	https://doi.org/10.1186/s12944-018-0930-2
Publication status	Published - 13 Dec 2018
MoE publication type	A1 Journal article-refereed

Fields of Science

USF1
High density lipoproteins
Cholesterol efflux
Cholesterol accumulation
Macrophage
Hepatocyte
Inflammation
FAMILIAL COMBINED HYPERLIPIDEMIA
UPSTREAM TRANSCRIPTION FACTOR-1
HIGH-DENSITY-LIPOPROTEINS
LYSOSOMAL ACID LIPASE
ESTER HYDROLASE 1
FOAM CELLS
HIGH-RISK
ATHEROSCLEROSIS
ASSOCIATION
CAPACITY
3111 Biomedicine
1182 Biochemistry, cell and molecular biology

Access to Document

10.1186/s12944-018-0930-2

s12944-018-0930-2Final published version, 1.91 MBLicence: CC BY

Cite this

Ruuth, M., Soronen, J., Kaiharju, E., Merikanto, K., Perttilä, J., Metso, J., Lee-Rueckert, M., Taskinen, M-R., Kovanen, P. T., Öörni, K., Olkkonen, V. M., Jauhiainen, M. S., & Laurila, P-P. (2018). USF1 deficiency alleviates inflammation, enhances cholesterol efflux and prevents cholesterol accumulation in macrophages. Lipids in Health and Disease, 17, [285]. https://doi.org/10.1186/s12944-018-0930-2

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title = "USF1 deficiency alleviates inflammation, enhances cholesterol efflux and prevents cholesterol accumulation in macrophages",

keywords = "USF1, High density lipoproteins, Cholesterol efflux, Cholesterol accumulation, Macrophage, Hepatocyte, Inflammation, FAMILIAL COMBINED HYPERLIPIDEMIA, UPSTREAM TRANSCRIPTION FACTOR-1, HIGH-DENSITY-LIPOPROTEINS, LYSOSOMAL ACID LIPASE, ESTER HYDROLASE 1, FOAM CELLS, HIGH-RISK, ATHEROSCLEROSIS, ASSOCIATION, CAPACITY, 3111 Biomedicine, 1182 Biochemistry, cell and molecular biology",

author = "Maija Ruuth and Jarkko Soronen and Essi Kaiharju and Krista Merikanto and Julia Perttil{\"a} and Jari Metso and Miriam Lee-Rueckert and Marja-Riitta Taskinen and Kovanen, {Petri T.} and Katariina {\"O}{\"o}rni and Olkkonen, {Vesa M.} and Jauhiainen, {Matti S.} and Pirkka-Pekka Laurila",

year = "2018",

month = dec,

day = "13",

doi = "10.1186/s12944-018-0930-2",

language = "English",

volume = "17",

journal = "Lipids in Health and Disease",

issn = "1476-511X",

publisher = "BMC",

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Ruuth, M, Soronen, J, Kaiharju, E, Merikanto, K, Perttilä, J, Metso, J, Lee-Rueckert, M, Taskinen, M-R , Kovanen, PT, Öörni, K, Olkkonen, VM, Jauhiainen, MS & Laurila, P-P 2018, 'USF1 deficiency alleviates inflammation, enhances cholesterol efflux and prevents cholesterol accumulation in macrophages', Lipids in Health and Disease, vol. 17, 285. https://doi.org/10.1186/s12944-018-0930-2

TY - JOUR

T1 - USF1 deficiency alleviates inflammation, enhances cholesterol efflux and prevents cholesterol accumulation in macrophages

AU - Ruuth, Maija

AU - Soronen, Jarkko

AU - Kaiharju, Essi

AU - Merikanto, Krista

AU - Perttilä, Julia

AU - Metso, Jari

AU - Lee-Rueckert, Miriam

AU - Taskinen, Marja-Riitta

AU - Kovanen, Petri T.

AU - Öörni, Katariina

AU - Olkkonen, Vesa M.

AU - Jauhiainen, Matti S.

AU - Laurila, Pirkka-Pekka

PY - 2018/12/13

Y1 - 2018/12/13

KW - USF1

KW - High density lipoproteins

KW - Cholesterol efflux

KW - Cholesterol accumulation

KW - Macrophage

KW - Hepatocyte

KW - Inflammation

KW - FAMILIAL COMBINED HYPERLIPIDEMIA

KW - UPSTREAM TRANSCRIPTION FACTOR-1

KW - HIGH-DENSITY-LIPOPROTEINS

KW - LYSOSOMAL ACID LIPASE

KW - ESTER HYDROLASE 1

KW - FOAM CELLS

KW - HIGH-RISK

KW - ATHEROSCLEROSIS

KW - ASSOCIATION

KW - CAPACITY

KW - 3111 Biomedicine

KW - 1182 Biochemistry, cell and molecular biology

U2 - 10.1186/s12944-018-0930-2

DO - 10.1186/s12944-018-0930-2

M3 - Article

VL - 17

JO - Lipids in Health and Disease

JF - Lipids in Health and Disease

SN - 1476-511X

M1 - 285

ER -