Utilising Induced Pluripotent Stem Cells in Neurodegenerative Disease Research: Focus on Glia

Katrina Albert, Jonna Niskanen, Sara Kälvälä, Šárka Lehtonen

Research output: Contribution to journalReview Articlepeer-review

Abstract

Induced pluripotent stem cells (iPSCs) are a self-renewable pool of cells derived from an organism’s somatic cells. These can then be programmed to other cell types, including neurons. Use of iPSCs in research has been two-fold as they have been used for human disease modelling as well as for the possibility to generate new therapies. Particularly in complex human diseases, such as neurodegenerative diseases, iPSCs can give advantages over traditional animal models in that they more accurately represent the human genome. Additionally, patient-derived cells can be modified using gene editing technology and further transplanted to the brain. Glial cells have recently become important avenues of research in the field of neurodegenerative diseases, for example, in Alzheimer’s disease and Parkinson’s disease. This review focuses on using glial cells (astrocytes, microglia, and oligodendrocytes) derived from human iPSCs in order to give a better understanding of how these cells contribute to neurodegenerative disease pathology. Using glia iPSCs in in vitro cell culture, cerebral organoids, and intracranial transplantation may give us future insight into both more accurate models and disease-modifying therapies.
Original languageEnglish
Article number4334
JournalInternational Journal of Molecular Sciences
Volume22
Issue number9
Number of pages28
ISSN1422-0067
DOIs
Publication statusPublished - May 2021
MoE publication typeA2 Review article in a scientific journal

Fields of Science

  • 3112 Neurosciences
  • 1182 Biochemistry, cell and molecular biology
  • astrocytes
  • microglia
  • oligodendrocytes
  • induced pluripotent stem cells
  • transplantation
  • organoids
  • neurodegenerative disease
  • humanized models
  • NEURAL PROGENITOR CELLS
  • FETAL MESENCEPHALIC TISSUE
  • PARKINSONS-DISEASE
  • ALZHEIMERS-DISEASE
  • TRANSGENIC MICE
  • IN-VIVO
  • EFFICIENT GENERATION
  • ASTROCYTE DYSFUNCTION
  • DOPAMINERGIC-NEURONS
  • FUNCTIONAL RECOVERY

Cite this