Utilizing Monocarboxylate Transporter 1-Mediated Blood-Brain Barrier Penetration for Glioblastoma Positron Emission Tomography Imaging with 6-[18F]Fluoronicotinic Acid

Pyry Dillemuth; Abiodun Ayo; Tomi T. Airenne; Petter Lövdahl; Emel Bakay; Xiaoqing Zhuang; Heidi Liljenbäck; Sami Tuomas Paunonen; Jonne Kunnas; Pauliina Filppu; Johan Rajander; Mark S. Johnson; Anne Roivainen; Tiina A. Salminen; Jessica M. Rosenholm; Pirjo Laakkonen; Xiang-Guo Li

doi:10.1021/acs.molpharmaceut.5c00457

Utilizing Monocarboxylate Transporter 1-Mediated Blood-Brain Barrier Penetration for Glioblastoma Positron Emission Tomography Imaging with 6-[18F]Fluoronicotinic Acid

Pyry Dillemuth, Abiodun Ayo, Tomi T. Airenne, Petter Lövdahl, Emel Bakay, Xiaoqing Zhuang, Heidi Liljenbäck, Sami Tuomas Paunonen, Jonne Kunnas, Pauliina Filppu, Johan Rajander, Mark S. Johnson, Anne Roivainen, Tiina A. Salminen, Jessica M. Rosenholm, Pirjo Laakkonen, Xiang-Guo Li

Research output: Contribution to journal › Article › Scientific › peer-review

Original language	English
Journal	Molecular Pharmaceutics
Number of pages	12
ISSN	1543-8384
DOIs	https://doi.org/10.1021/acs.molpharmaceut.5c00457
Publication status	Published - 3 Jul 2025
MoE publication type	A1 Journal article-refereed

Fields of Science

G protein-coupledreceptor GPR109A
Fluorine-18
Glioblastoma
Monocarboxylate transporter 1
Niacin
Nicotinic acid
3111 Biomedicine
318 Medical biotechnology

Access to Document

10.1021/acs.molpharmaceut.5c00457

dillemuth-et-al-2025-utilizing-monocarboxylate-transporter-1-mediated-blood-brain-barrier-penetration-for-glioblastomaFinal published version, 10.8 MBLicence: CC BY

Cite this

Dillemuth, P., Ayo, A., Airenne, T. T., Lövdahl, P., Bakay, E., Zhuang, X., Liljenbäck, H., Paunonen, S. T., Kunnas, J., Filppu, P., Rajander, J., Johnson, M. S., Roivainen, A., Salminen, T. A., Rosenholm, J. M., Laakkonen, P., & Li, X.-G. (2025). Utilizing Monocarboxylate Transporter 1-Mediated Blood-Brain Barrier Penetration for Glioblastoma Positron Emission Tomography Imaging with 6-[18F]Fluoronicotinic Acid. Molecular Pharmaceutics. https://doi.org/10.1021/acs.molpharmaceut.5c00457

@article{06f4c1a5424f4fdc8828a2d6ffbb9007,

title = "Utilizing Monocarboxylate Transporter 1-Mediated Blood-Brain Barrier Penetration for Glioblastoma Positron Emission Tomography Imaging with 6-[18F]Fluoronicotinic Acid",

keywords = "G protein-coupledreceptor GPR109A, Fluorine-18, Glioblastoma, Monocarboxylate transporter 1, Niacin, Nicotinic acid, 3111 Biomedicine, 318 Medical biotechnology",

author = "Pyry Dillemuth and Abiodun Ayo and Airenne, \{Tomi T.\} and Petter L{\"o}vdahl and Emel Bakay and Xiaoqing Zhuang and Heidi Liljenb{\"a}ck and Paunonen, \{Sami Tuomas\} and Jonne Kunnas and Pauliina Filppu and Johan Rajander and Johnson, \{Mark S.\} and Anne Roivainen and Salminen, \{Tiina A.\} and Rosenholm, \{Jessica M.\} and Pirjo Laakkonen and Xiang-Guo Li",

year = "2025",

month = jul,

day = "3",

doi = "10.1021/acs.molpharmaceut.5c00457",

language = "English",

journal = "Molecular Pharmaceutics",

issn = "1543-8384",

publisher = "American Chemical Society",

}

Dillemuth, P, Ayo, A, Airenne, TT, Lövdahl, P, Bakay, E, Zhuang, X, Liljenbäck, H, Paunonen, ST, Kunnas, J, Filppu, P, Rajander, J, Johnson, MS, Roivainen, A, Salminen, TA, Rosenholm, JM, Laakkonen, P & Li, X-G 2025, 'Utilizing Monocarboxylate Transporter 1-Mediated Blood-Brain Barrier Penetration for Glioblastoma Positron Emission Tomography Imaging with 6-[18F]Fluoronicotinic Acid', Molecular Pharmaceutics. https://doi.org/10.1021/acs.molpharmaceut.5c00457

TY - JOUR

T1 - Utilizing Monocarboxylate Transporter 1-Mediated Blood-Brain Barrier Penetration for Glioblastoma Positron Emission Tomography Imaging with 6-[18F]Fluoronicotinic Acid

AU - Dillemuth, Pyry

AU - Ayo, Abiodun

AU - Airenne, Tomi T.

AU - Lövdahl, Petter

AU - Bakay, Emel

AU - Zhuang, Xiaoqing

AU - Liljenbäck, Heidi

AU - Paunonen, Sami Tuomas

AU - Kunnas, Jonne

AU - Filppu, Pauliina

AU - Rajander, Johan

AU - Johnson, Mark S.

AU - Roivainen, Anne

AU - Salminen, Tiina A.

AU - Rosenholm, Jessica M.

AU - Laakkonen, Pirjo

AU - Li, Xiang-Guo

PY - 2025/7/3

Y1 - 2025/7/3

KW - G protein-coupledreceptor GPR109A

KW - Fluorine-18

KW - Glioblastoma

KW - Monocarboxylate transporter 1

KW - Niacin

KW - Nicotinic acid

KW - 3111 Biomedicine

KW - 318 Medical biotechnology

U2 - 10.1021/acs.molpharmaceut.5c00457

DO - 10.1021/acs.molpharmaceut.5c00457

M3 - Article

C2 - 40610391

SN - 1543-8384

JO - Molecular Pharmaceutics

JF - Molecular Pharmaceutics

ER -