Variation at 2q35 (PNKD and TMBIM1) influences colorectal cancer risk and identifies a pleiotropic effect with inflammatory bowel disease

Giulia Orlando, Philip J. Law, Kimmo Palin, Sari Tuupanen, Alexandra Gylfe, Ulrika A. Hanninen, Tatiana Cajuso, Tomas Tanskanen, Johanna Kondelin, Eevi Kaasinen, Antti-Pekka Sarin, Jaakko Kaprio, Johan G. Eriksson, Harri Rissanen, Paul Knekt, Eero Pukkala, Pekka Jousilahti, Veikko Salomaa, Samuli Ripatti, Aarno Palotie & 37 others Heikki Järvinen, Laura Renkonen-Sinisalo, Anna Lepisto, Jan Bohm, Jukka-Pekka Mecklin, Nada A. Al-Tassan, Claire Palles, Lynn Martin, Ella Barclay, Albert Tenesa, Susan Farrington, Maria N. Timofeeva, Brian F. Meyer, Salma M. Wakil, Harry Campbell, Christopher G. Smith, Shelley Idziaszczyk, Timothy S. Maughan, Richard Kaplan, Rachel Kerr, David Kerr, Daniel D. Buchanan, Aung Ko Win, John Hopper, Mark Jenkins, Noralane M. Lindor, Polly A. Newcomb, Steve Gallinger, David Conti, Fred Schumacher, Graham Casey, Jussi Taipale, Jeremy P. Cheadle, Malcolm G. Dunlop, Ian P. Tomlinson, Lauri A. Aaltonen, Richard S. Houlston

Research output: Contribution to journalArticleScientificpeer-review

Original languageEnglish
JournalHuman Molecular Genetics
Volume25
Issue number11
Pages (from-to)2349-2359
Number of pages11
ISSN0964-6906
DOIs
Publication statusPublished - 1 Jun 2016
MoE publication typeA1 Journal article-refereed

Fields of Science

  • GENOME-WIDE ASSOCIATION
  • SUSCEPTIBILITY LOCI
  • INTESTINAL INFLAMMATION
  • FUNCTIONAL VARIATION
  • CROHNS-DISEASE
  • COHORT PROFILE
  • BIRTH COHORT
  • METAANALYSIS
  • IMPUTATION
  • VARIANTS
  • 3111 Biomedicine
  • 3121 Internal medicine
  • 3122 Cancers
  • 3126 Surgery, anesthesiology, intensive care, radiology

Cite this

Orlando, Giulia ; Law, Philip J. ; Palin, Kimmo ; Tuupanen, Sari ; Gylfe, Alexandra ; Hanninen, Ulrika A. ; Cajuso, Tatiana ; Tanskanen, Tomas ; Kondelin, Johanna ; Kaasinen, Eevi ; Sarin, Antti-Pekka ; Kaprio, Jaakko ; Eriksson, Johan G. ; Rissanen, Harri ; Knekt, Paul ; Pukkala, Eero ; Jousilahti, Pekka ; Salomaa, Veikko ; Ripatti, Samuli ; Palotie, Aarno ; Järvinen, Heikki ; Renkonen-Sinisalo, Laura ; Lepisto, Anna ; Bohm, Jan ; Mecklin, Jukka-Pekka ; Al-Tassan, Nada A. ; Palles, Claire ; Martin, Lynn ; Barclay, Ella ; Tenesa, Albert ; Farrington, Susan ; Timofeeva, Maria N. ; Meyer, Brian F. ; Wakil, Salma M. ; Campbell, Harry ; Smith, Christopher G. ; Idziaszczyk, Shelley ; Maughan, Timothy S. ; Kaplan, Richard ; Kerr, Rachel ; Kerr, David ; Buchanan, Daniel D. ; Win, Aung Ko ; Hopper, John ; Jenkins, Mark ; Lindor, Noralane M. ; Newcomb, Polly A. ; Gallinger, Steve ; Conti, David ; Schumacher, Fred ; Casey, Graham ; Taipale, Jussi ; Cheadle, Jeremy P. ; Dunlop, Malcolm G. ; Tomlinson, Ian P. ; Aaltonen, Lauri A. ; Houlston, Richard S. / Variation at 2q35 (PNKD and TMBIM1) influences colorectal cancer risk and identifies a pleiotropic effect with inflammatory bowel disease. In: Human Molecular Genetics. 2016 ; Vol. 25, No. 11. pp. 2349-2359.
@article{68bbf3adf1fb4533b01f96c6922e043d,
title = "Variation at 2q35 (PNKD and TMBIM1) influences colorectal cancer risk and identifies a pleiotropic effect with inflammatory bowel disease",
keywords = "GENOME-WIDE ASSOCIATION, SUSCEPTIBILITY LOCI, INTESTINAL INFLAMMATION, FUNCTIONAL VARIATION, CROHNS-DISEASE, COHORT PROFILE, BIRTH COHORT, METAANALYSIS, IMPUTATION, VARIANTS, 3111 Biomedicine, 3121 Internal medicine, 3122 Cancers, 3126 Surgery, anesthesiology, intensive care, radiology",
author = "Giulia Orlando and Law, {Philip J.} and Kimmo Palin and Sari Tuupanen and Alexandra Gylfe and Hanninen, {Ulrika A.} and Tatiana Cajuso and Tomas Tanskanen and Johanna Kondelin and Eevi Kaasinen and Antti-Pekka Sarin and Jaakko Kaprio and Eriksson, {Johan G.} and Harri Rissanen and Paul Knekt and Eero Pukkala and Pekka Jousilahti and Veikko Salomaa and Samuli Ripatti and Aarno Palotie and Heikki J{\"a}rvinen and Laura Renkonen-Sinisalo and Anna Lepisto and Jan Bohm and Jukka-Pekka Mecklin and Al-Tassan, {Nada A.} and Claire Palles and Lynn Martin and Ella Barclay and Albert Tenesa and Susan Farrington and Timofeeva, {Maria N.} and Meyer, {Brian F.} and Wakil, {Salma M.} and Harry Campbell and Smith, {Christopher G.} and Shelley Idziaszczyk and Maughan, {Timothy S.} and Richard Kaplan and Rachel Kerr and David Kerr and Buchanan, {Daniel D.} and Win, {Aung Ko} and John Hopper and Mark Jenkins and Lindor, {Noralane M.} and Newcomb, {Polly A.} and Steve Gallinger and David Conti and Fred Schumacher and Graham Casey and Jussi Taipale and Cheadle, {Jeremy P.} and Dunlop, {Malcolm G.} and Tomlinson, {Ian P.} and Aaltonen, {Lauri A.} and Houlston, {Richard S.}",
year = "2016",
month = "6",
day = "1",
doi = "10.1093/hmg/ddw087",
language = "English",
volume = "25",
pages = "2349--2359",
journal = "Human Molecular Genetics",
issn = "0964-6906",
publisher = "Oxford University Press",
number = "11",

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Orlando, G, Law, PJ, Palin, K, Tuupanen, S, Gylfe, A, Hanninen, UA, Cajuso, T, Tanskanen, T, Kondelin, J, Kaasinen, E, Sarin, A-P, Kaprio, J, Eriksson, JG, Rissanen, H, Knekt, P, Pukkala, E, Jousilahti, P, Salomaa, V, Ripatti, S, Palotie, A, Järvinen, H, Renkonen-Sinisalo, L, Lepisto, A, Bohm, J, Mecklin, J-P, Al-Tassan, NA, Palles, C, Martin, L, Barclay, E, Tenesa, A, Farrington, S, Timofeeva, MN, Meyer, BF, Wakil, SM, Campbell, H, Smith, CG, Idziaszczyk, S, Maughan, TS, Kaplan, R, Kerr, R, Kerr, D, Buchanan, DD, Win, AK, Hopper, J, Jenkins, M, Lindor, NM, Newcomb, PA, Gallinger, S, Conti, D, Schumacher, F, Casey, G, Taipale, J, Cheadle, JP, Dunlop, MG, Tomlinson, IP, Aaltonen, LA & Houlston, RS 2016, 'Variation at 2q35 (PNKD and TMBIM1) influences colorectal cancer risk and identifies a pleiotropic effect with inflammatory bowel disease', Human Molecular Genetics, vol. 25, no. 11, pp. 2349-2359. https://doi.org/10.1093/hmg/ddw087

Variation at 2q35 (PNKD and TMBIM1) influences colorectal cancer risk and identifies a pleiotropic effect with inflammatory bowel disease. / Orlando, Giulia; Law, Philip J.; Palin, Kimmo; Tuupanen, Sari; Gylfe, Alexandra; Hanninen, Ulrika A.; Cajuso, Tatiana; Tanskanen, Tomas; Kondelin, Johanna; Kaasinen, Eevi; Sarin, Antti-Pekka; Kaprio, Jaakko; Eriksson, Johan G.; Rissanen, Harri; Knekt, Paul; Pukkala, Eero; Jousilahti, Pekka; Salomaa, Veikko; Ripatti, Samuli; Palotie, Aarno; Järvinen, Heikki; Renkonen-Sinisalo, Laura; Lepisto, Anna; Bohm, Jan; Mecklin, Jukka-Pekka; Al-Tassan, Nada A.; Palles, Claire; Martin, Lynn; Barclay, Ella; Tenesa, Albert; Farrington, Susan; Timofeeva, Maria N.; Meyer, Brian F.; Wakil, Salma M.; Campbell, Harry; Smith, Christopher G.; Idziaszczyk, Shelley; Maughan, Timothy S.; Kaplan, Richard; Kerr, Rachel; Kerr, David; Buchanan, Daniel D.; Win, Aung Ko; Hopper, John; Jenkins, Mark; Lindor, Noralane M.; Newcomb, Polly A.; Gallinger, Steve; Conti, David; Schumacher, Fred; Casey, Graham; Taipale, Jussi; Cheadle, Jeremy P.; Dunlop, Malcolm G.; Tomlinson, Ian P.; Aaltonen, Lauri A.; Houlston, Richard S.

In: Human Molecular Genetics, Vol. 25, No. 11, 01.06.2016, p. 2349-2359.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Variation at 2q35 (PNKD and TMBIM1) influences colorectal cancer risk and identifies a pleiotropic effect with inflammatory bowel disease

AU - Orlando, Giulia

AU - Law, Philip J.

AU - Palin, Kimmo

AU - Tuupanen, Sari

AU - Gylfe, Alexandra

AU - Hanninen, Ulrika A.

AU - Cajuso, Tatiana

AU - Tanskanen, Tomas

AU - Kondelin, Johanna

AU - Kaasinen, Eevi

AU - Sarin, Antti-Pekka

AU - Kaprio, Jaakko

AU - Eriksson, Johan G.

AU - Rissanen, Harri

AU - Knekt, Paul

AU - Pukkala, Eero

AU - Jousilahti, Pekka

AU - Salomaa, Veikko

AU - Ripatti, Samuli

AU - Palotie, Aarno

AU - Järvinen, Heikki

AU - Renkonen-Sinisalo, Laura

AU - Lepisto, Anna

AU - Bohm, Jan

AU - Mecklin, Jukka-Pekka

AU - Al-Tassan, Nada A.

AU - Palles, Claire

AU - Martin, Lynn

AU - Barclay, Ella

AU - Tenesa, Albert

AU - Farrington, Susan

AU - Timofeeva, Maria N.

AU - Meyer, Brian F.

AU - Wakil, Salma M.

AU - Campbell, Harry

AU - Smith, Christopher G.

AU - Idziaszczyk, Shelley

AU - Maughan, Timothy S.

AU - Kaplan, Richard

AU - Kerr, Rachel

AU - Kerr, David

AU - Buchanan, Daniel D.

AU - Win, Aung Ko

AU - Hopper, John

AU - Jenkins, Mark

AU - Lindor, Noralane M.

AU - Newcomb, Polly A.

AU - Gallinger, Steve

AU - Conti, David

AU - Schumacher, Fred

AU - Casey, Graham

AU - Taipale, Jussi

AU - Cheadle, Jeremy P.

AU - Dunlop, Malcolm G.

AU - Tomlinson, Ian P.

AU - Aaltonen, Lauri A.

AU - Houlston, Richard S.

PY - 2016/6/1

Y1 - 2016/6/1

KW - GENOME-WIDE ASSOCIATION

KW - SUSCEPTIBILITY LOCI

KW - INTESTINAL INFLAMMATION

KW - FUNCTIONAL VARIATION

KW - CROHNS-DISEASE

KW - COHORT PROFILE

KW - BIRTH COHORT

KW - METAANALYSIS

KW - IMPUTATION

KW - VARIANTS

KW - 3111 Biomedicine

KW - 3121 Internal medicine

KW - 3122 Cancers

KW - 3126 Surgery, anesthesiology, intensive care, radiology

U2 - 10.1093/hmg/ddw087

DO - 10.1093/hmg/ddw087

M3 - Article

VL - 25

SP - 2349

EP - 2359

JO - Human Molecular Genetics

JF - Human Molecular Genetics

SN - 0964-6906

IS - 11

ER -