Vitamin A as a Transcriptional Regulator of Cardiovascular Disease

Research output: Contribution to journalReview Articlepeer-review


Vitamin A is a micronutrient and signaling molecule that regulates transcription,
cellular differentiation, and organ homeostasis. Additionally, metabolites of Vitamin A are utilized as
differentiation agents in the treatment of hematological cancers and skin disorders, necessitating further
study into the effects of both nutrient deficiency and the exogenous delivery of Vitamin A and its
metabolites on cardiovascular phenotypes. Though vitamin A/retinoids are well-known regulators
of cardiac formation, recent evidence has emerged that supports their role as regulators of cardiac
regeneration, postnatal cardiac function, and cardiovascular disease progression. We here review
findings from genetic and pharmacological studies describing the regulation of both myocyte- and
vascular-driven cardiac phenotypes by vitamin A signaling. We identify the relationship between
retinoids and maladaptive processes during the pathological hypertrophy of the heart, with a
focus on the activation of neurohormonal signaling and fetal transcription factors (Gata4, Tbx5).
Finally, we assess how this information might be leveraged to develop novel therapeutic avenues
Original languageEnglish
Issue number2
Pages (from-to)126-145
Publication statusPublished - 21 Aug 2020
MoE publication typeA2 Review article in a scientific journal

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