Waist and hip circumference are independently associated with the risk of liver disease in population-based studies

Oscar A Danielsson; Markku Nissinen; Antti Jula; Veikko Salomaa; Satu Männistö; Annamari Lundqvist; Markus Perola; Fredrik Åberg

doi:10.1111/liv.15053

Waist and hip circumference are independently associated with the risk of liver disease in population-based studies

Oscar A Danielsson, Markku Nissinen, Antti Jula, Veikko Salomaa, Satu Männistö, Annamari Lundqvist, Markus Perola, Fredrik Åberg

Research output: Contribution to journal › Article › Scientific › peer-review

Abstract

Background & Aims While several anthropometric measures predict liver disease, the waist-hip ratio (WHR) has shown superiority in previous studies. We analysed independent and joint associations of waist circumference (WC) and hip circumference (HC) with liver disease and liver-related risk factors. Methods Cross-sectional study (n = 6619) and longitudinal cohort (n = 40 923) comprised individuals from Health 2000 and FINRISK 1992-2012 studies. Prevalent and viral liver diseases were excluded. Longitudinal cohort was linked with national healthcare registers for severe incident liver disease. Linear regression and Cox proportional hazards models were used to analyse anthropometric, lifestyle, metabolic and bioimpedance-related parameters; liver enzymes; and 59 liver-related genetic risk variants. Results WC and HC showed independent and opposite associations with both liver enzymes and incident liver disease among men (HR for liver disease: WC, 1.07, 95% CI 1.03-1.11; HC, 0.96, 95% CI 0.92-0.99; P-range .04 to

Original language	English
Journal	Liver International
Volume	41
Issue number	12
Pages (from-to)	2903-2913
Number of pages	11
ISSN	1478-3223
DOIs	https://doi.org/10.1111/liv.15053
Publication status	Published - Dec 2021
MoE publication type	A1 Journal article-refereed

Fields of Science

BODY-COMPOSITION
CARDIOVASCULAR RISK
FATTY LIVER
INSULIN-RESISTANCE
NORMAL-WEIGHT
OBESITY
PREDICTS DEVELOPMENT
RATIO
SKELETAL-MUSCLE MASS
WHOLE-BODY
anthropometric measures
body mass index
fat
sarcopenia
waist-hip ratio
3121 General medicine, internal medicine and other clinical medicine

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10.1111/liv.15053

Liver International - 2021 - Danielsson - Waist and hip circumference are independently associated with the risk of liverFinal published version, 1.09 MBLicence: CC BY

Cite this

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title = "Waist and hip circumference are independently associated with the risk of liver disease in population-based studies",

abstract = "Background & Aims While several anthropometric measures predict liver disease, the waist-hip ratio (WHR) has shown superiority in previous studies. We analysed independent and joint associations of waist circumference (WC) and hip circumference (HC) with liver disease and liver-related risk factors. Methods Cross-sectional study (n = 6619) and longitudinal cohort (n = 40 923) comprised individuals from Health 2000 and FINRISK 1992-2012 studies. Prevalent and viral liver diseases were excluded. Longitudinal cohort was linked with national healthcare registers for severe incident liver disease. Linear regression and Cox proportional hazards models were used to analyse anthropometric, lifestyle, metabolic and bioimpedance-related parameters; liver enzymes; and 59 liver-related genetic risk variants. Results WC and HC showed independent and opposite associations with both liver enzymes and incident liver disease among men (HR for liver disease: WC, 1.07, 95% CI 1.03-1.11; HC, 0.96, 95% CI 0.92-0.99; P-range .04 to",

keywords = "BODY-COMPOSITION, CARDIOVASCULAR RISK, FATTY LIVER, INSULIN-RESISTANCE, NORMAL-WEIGHT, OBESITY, PREDICTS DEVELOPMENT, RATIO, SKELETAL-MUSCLE MASS, WHOLE-BODY, anthropometric measures, body mass index, fat, sarcopenia, waist-hip ratio, 3121 General medicine, internal medicine and other clinical medicine",

author = "Danielsson, {Oscar A} and Markku Nissinen and Antti Jula and Veikko Salomaa and Satu M{\"a}nnist{\"o} and Annamari Lundqvist and Markus Perola and Fredrik {\AA}berg",

year = "2021",

month = dec,

doi = "10.1111/liv.15053",

language = "English",

volume = "41",

pages = "2903--2913",

journal = "Liver International",

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T1 - Waist and hip circumference are independently associated with the risk of liver disease in population-based studies

AU - Danielsson, Oscar A

AU - Nissinen, Markku

AU - Jula, Antti

AU - Salomaa, Veikko

AU - Männistö, Satu

AU - Lundqvist, Annamari

AU - Perola, Markus

AU - Åberg, Fredrik

PY - 2021/12

Y1 - 2021/12

N2 - Background & Aims While several anthropometric measures predict liver disease, the waist-hip ratio (WHR) has shown superiority in previous studies. We analysed independent and joint associations of waist circumference (WC) and hip circumference (HC) with liver disease and liver-related risk factors. Methods Cross-sectional study (n = 6619) and longitudinal cohort (n = 40 923) comprised individuals from Health 2000 and FINRISK 1992-2012 studies. Prevalent and viral liver diseases were excluded. Longitudinal cohort was linked with national healthcare registers for severe incident liver disease. Linear regression and Cox proportional hazards models were used to analyse anthropometric, lifestyle, metabolic and bioimpedance-related parameters; liver enzymes; and 59 liver-related genetic risk variants. Results WC and HC showed independent and opposite associations with both liver enzymes and incident liver disease among men (HR for liver disease: WC, 1.07, 95% CI 1.03-1.11; HC, 0.96, 95% CI 0.92-0.99; P-range .04 to

AB - Background & Aims While several anthropometric measures predict liver disease, the waist-hip ratio (WHR) has shown superiority in previous studies. We analysed independent and joint associations of waist circumference (WC) and hip circumference (HC) with liver disease and liver-related risk factors. Methods Cross-sectional study (n = 6619) and longitudinal cohort (n = 40 923) comprised individuals from Health 2000 and FINRISK 1992-2012 studies. Prevalent and viral liver diseases were excluded. Longitudinal cohort was linked with national healthcare registers for severe incident liver disease. Linear regression and Cox proportional hazards models were used to analyse anthropometric, lifestyle, metabolic and bioimpedance-related parameters; liver enzymes; and 59 liver-related genetic risk variants. Results WC and HC showed independent and opposite associations with both liver enzymes and incident liver disease among men (HR for liver disease: WC, 1.07, 95% CI 1.03-1.11; HC, 0.96, 95% CI 0.92-0.99; P-range .04 to

KW - BODY-COMPOSITION

KW - CARDIOVASCULAR RISK

KW - FATTY LIVER

KW - INSULIN-RESISTANCE

KW - NORMAL-WEIGHT

KW - OBESITY

KW - PREDICTS DEVELOPMENT

KW - RATIO

KW - SKELETAL-MUSCLE MASS

KW - WHOLE-BODY

KW - anthropometric measures

KW - body mass index

KW - fat

KW - sarcopenia

KW - waist-hip ratio

KW - 3121 General medicine, internal medicine and other clinical medicine

U2 - 10.1111/liv.15053

DO - 10.1111/liv.15053

M3 - Article

SN - 1478-3223

VL - 41

SP - 2903

EP - 2913

JO - Liver International

JF - Liver International

IS - 12

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