Western diet enhances intestinal tumorigenesis in Min/ plus mice, associating with mucosal metabolic and inflammatory stress and loss of Apc heterozygosity

Mikael Niku, Anne-Maria Pajari, Laura Sarantaus, Essi Päivärinta, Markus Storvik, Anu Heiman-Lindh, Santeri Suokas, Minna Nyström, Marja Mutanen

Research output: Contribution to journalArticleScientificpeer-review

Original languageEnglish
JournalJournal of Nutritional Biochemistry
Volume39
Pages (from-to)126-133
Number of pages8
ISSN0955-2863
DOIs
Publication statusPublished - Jan 2017
MoE publication typeA1 Journal article-refereed

Fields of Science

  • High-risk Western-type diet
  • Intestinal cancer
  • Energy metabolism
  • Loss of heterozygosity
  • PDK4
  • ERK
  • Apc(min/+) mice
  • HIGH-FAT DIET
  • COLON-CANCER
  • APC(MIN/+) MICE
  • BETA-CATENIN
  • CELL-PROLIFERATION
  • INSULIN-RESISTANCE
  • TUMOR-FORMATION
  • DNA-DAMAGE
  • EXPRESSION
  • INHIBITOR
  • 1182 Biochemistry, cell and molecular biology

Cite this

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title = "Western diet enhances intestinal tumorigenesis in Min/ plus mice, associating with mucosal metabolic and inflammatory stress and loss of Apc heterozygosity",
keywords = "High-risk Western-type diet, Intestinal cancer, Energy metabolism, Loss of heterozygosity, PDK4, ERK, Apc(min/+) mice, HIGH-FAT DIET, COLON-CANCER, APC(MIN/+) MICE, BETA-CATENIN, CELL-PROLIFERATION, INSULIN-RESISTANCE, TUMOR-FORMATION, DNA-DAMAGE, EXPRESSION, INHIBITOR, 1182 Biochemistry, cell and molecular biology",
author = "Mikael Niku and Anne-Maria Pajari and Laura Sarantaus and Essi P{\"a}iv{\"a}rinta and Markus Storvik and Anu Heiman-Lindh and Santeri Suokas and Minna Nystr{\"o}m and Marja Mutanen",
year = "2017",
month = "1",
doi = "10.1016/j.jnutbio.2016.09.016",
language = "English",
volume = "39",
pages = "126--133",
journal = "Journal of Nutritional Biochemistry",
issn = "0955-2863",
publisher = "ACADEMIC PRESS INC ELSEVIER SCIENCE",

}

TY - JOUR

T1 - Western diet enhances intestinal tumorigenesis in Min/ plus mice, associating with mucosal metabolic and inflammatory stress and loss of Apc heterozygosity

AU - Niku, Mikael

AU - Pajari, Anne-Maria

AU - Sarantaus, Laura

AU - Päivärinta, Essi

AU - Storvik, Markus

AU - Heiman-Lindh, Anu

AU - Suokas, Santeri

AU - Nyström, Minna

AU - Mutanen, Marja

PY - 2017/1

Y1 - 2017/1

KW - High-risk Western-type diet

KW - Intestinal cancer

KW - Energy metabolism

KW - Loss of heterozygosity

KW - PDK4

KW - ERK

KW - Apc(min/+) mice

KW - HIGH-FAT DIET

KW - COLON-CANCER

KW - APC(MIN/+) MICE

KW - BETA-CATENIN

KW - CELL-PROLIFERATION

KW - INSULIN-RESISTANCE

KW - TUMOR-FORMATION

KW - DNA-DAMAGE

KW - EXPRESSION

KW - INHIBITOR

KW - 1182 Biochemistry, cell and molecular biology

U2 - 10.1016/j.jnutbio.2016.09.016

DO - 10.1016/j.jnutbio.2016.09.016

M3 - Article

VL - 39

SP - 126

EP - 133

JO - Journal of Nutritional Biochemistry

JF - Journal of Nutritional Biochemistry

SN - 0955-2863

ER -