The Ripatti group studies genome-wide variation and its relation to complex traits and diseases, with a particular focus, but not limited to, on cardiovascular diseases and metabolism. We build on our understanding of genome-wide variation, Finnish genetically and epidemiologically well-profiled cohorts and knowledge and development of statistical and computational tools, and aim at identifying variants, genes and genetic loci modifying complex disease risks. We also study ways to translate the findings into potential intervention targets and comprehensive disease risk assessments.