20132024

Tutkimustuotoksia vuodessa

Henkilökohtainen profiili

Ansioluettelo

Salem group

https://www.salem-lab.com/

My team focuses on understanding the different aspects of head and neck carcinogenesis. We have a particular focus on investigating the dynamic interplay between oral bacteria and cancer cells in head and neck cancers.

Specifically, we utilize ex vivo and in vivo assays to investigate the mechanestic effects of bacterial-derived vesicles and toxins on crucial tumorigenic events associated with carcinogenesis, such as phenotypic switching, invasion, metastasis, apoptosis and drug resistance.

Furthermore, we assess the clinical utility of bacterial-derived extracellular vesicles as therapeutic agents. We have so far uncovered important findings and established effective international collaboration.

To date, we have been instrumental in defining a previously unknown mechanism that potentially underpinning lymphatic metastasis in oral cancer (we coined the term Lymphatic Mimicry), and how particular inflammatory molecules (e.g. histamine) and bacterial toxins can influence the behavior of aggressive cancer cells.

For more information, please contact the PI at: [email protected]

Tieteenalat

  • 313 Hammaslääketieteet
  • 3121 Yleislääketiede, sisätaudit ja muut kliiniset lääketieteet
  • 3111 Biolääketieteet
  • 3122 Syöpätaudit

Kansainvälinen ja kotimainen yhteistyö

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