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Henkilökohtainen profiili

Ansioluettelo

1. Personal details and date of CV

2. Degrees

  • PhD, 1980, Genetics, Department of Genetics, University of Helsinki (UH), Finland
  • M.Sc. 1975, Genetics, Dept. of Genetics, UH, Finland
  • Title of Docent: Genetics, 1981-1993, Dept. of Genetics, UH, Finland

3. Current Employment

  • 18.12.2016, Professor Emeritus, Faculty of Biological and Environmental Sciences, UH

4. Previous work experience

  • 1993-2016, Professor in General Microbiology, Dept. of Biosciences, UH, Finland
  • 2012-2016, Academy Professor, Dept. of Biosciences & Institute of Biotechnology, UH
  • 2008-2011, Director, Finnish Center of Excellence in Virus Research, Dept. of Biosciences and Institute of Biotechnology, UH, Finland
  • 2002-2007, Academy Professor, Dept. of Biosciences & Institute of Biotechnology, UH
  • 1998-2002, Research Director, Professor, Institute of Biotechnology, UH, Finland
  • 1992-1997, Research Director, Professor, Institute of Biotechnology, UH, Finland
  • 1991-1992, Senior Scientist, Academy of Finland, UH, Finland
  • 1983-1991, Senior Researcher, Academy of Finland, UH, Finland
  • 1981-1982, EMBO postdoc. fellowship, Public Health Research Institute, New York, USA
  • 1975-1981, Teaching assistant, Dept. of Genetics, UH, Finland

5. Research funding and grants, supervision and leadership experience

Since 1983, I have had continuous external funding including two Center of Excellences (See below), two Academy Professor positions (See below) and several EU, Academy of Finland, TEKES and Jusélius Foundation funds as well as Human Frontier Science Program funding. Major research funding from 2006 onwards is listed below:

  • Academy of Finland: Academy Professor (255342), Individual funding, 704 831 €, 1.1.2012-31.12.2016. Role: PI
  • Academy of Finland: Academy Professor: funding for research expenses (283072), 541 977 €, 1.1.2015-31.12.2016. Role: PI
  • Academy of Finland: Academy Professor: funding for research expenses (256518), 800 684 €, 1.1.2012-31.12.2014. Role: PI
  • Academy of Finland: Finnish Participation in EU ESFRI Instruct Operation, (272853), 322 695 €, 1.1.2014-31.12.2015. Role: PI
  • Academy of Finland: Integrated Structural Biology Infrastructure, Instruct (ESFRI), (271413), 200 000 €, 14.12.2012-31.12.2014. Role: PI
  • Academy of Finland: Specificity in the RNA induced Innate Immunity Responses; an Enzymatic Toolkit for the Production of a Library of RNA Molecules (256197), Consortium (China, Germany, Finland), 230 000 €, 1.1.2012-31.12.2014. Role: Co-applicant.
  • Sigrid Jusélius Foundation: Virus-Specific RNAs and Polymerases as Molecular Targets and Tool for Drug Discovery. Collaboration, 167 400 €, 1.1.2013-31.12.2015. Role: Co-applicant.
  • EU COST Action, COST FA0806 (PlantiVax), 30.3.2009-29.3.2013.
  • Sigrid Jusélius Foundation: Viral RNA-Dependent RNA Polymerases as Tools and Targets for Antiviral Drug Design. Collaboration, 229 000 €, 1.6.2010-30.4.2013. Role: Co-applicant, Scientific Advisor.
  • Academy of Finland, Finnish Centre of Excellence in Virus Research. (213467, 129684), 2 268 000 €, 2006-2011. Role: PI, Research Director.
  • Academy of Finland, Finnish Centre of Excellence in Structural Virology. 2000-2005. Role: PI, Research Director.

6. Research output

  • Patents and biotechnical applications: “RNA polymerases from bacteriophage PHI 6-PHI 14 and use of thereof”, WO 01/46396 A1, Priority: 1999-12-21 FI1999000002751, Patents: AU 785036 B2, NZ 519679 A, EP1242586 B1) and biotechnical applications in the field of RNA interference and such enzymes are globally available through Thermo Fisher Scientific Inc.
  • EU ESFRI (European Strategy Forum on Research Infrastructures) Instruct (Integrated Structural Biology Research Infrastructure) Director, 2010-2016; Council, observer, 2010-2016; Committee, member, 2010-2016.
  • EU ESFRI Instruct, Instruct Centre for Virus Production, Committee, chair, 2010-2016; working group chairman, 2008-2009.

7. Teaching merits

  • Planning and implementation of teaching in genetics, molecular virology, and microbiology at UH for PhD, MSc and BSc students (1980à).
  • Viikki Graduate Program in Molecular Biosciences, UH, director 2008-2013, steering group member 2000-2007.
  • International EU COST Training School on dsRNA production for plant virus protection, Helsinki, 7-12.9.2009. Organizer.
  • Evaluation board member for Structured PhD Education, Irish Higher Education Authority, 17 – 19. 11.2009.

8. Awards and honours

  • European Academy of Microbiology, invited member, 2013.
  • Scientific Community’s golden decoration for 30 years of service pro science, 2013
  • Commander, Order of Finnish Lion, 2010
  • European Molecular Biology Organization (EMBO) member, elected 2006.
  • Societas Biochemica, Biophysica et Microbiologica Fenniae, honorary member, 2006.
  • University of Helsinki, Prize for scientific innovation (molecular biosciences), 2005.

9. Other key academic merits

  • Encyclopedia of Virology (Elsevier), fourth edition. Editor-in-Chief. 2017-2021.
  • External evaluator, Uppsala University (Sweden), 2017.
  • Steering group member, Publication Forum 2016-2020.
  • Editorial board membership, Journal of General Virology, 1981-1983; 2006–2010, Journal of Virology, 2006-2015.
  • International Committee on Taxonomy of Viruses, executive committee member 1996-2002, 2012- 2014; bacterial virus subcommittee chair on lipid-containing bacteriophages 1985-.
  • EMBL, Hamburg outstation evaluation board member, 2007.
  • Encyclopedia of Virology (Elsevier), associate editor responsible for bacterial and archaeal viruses, 2005-2008.
  • Virus Research, Special Issue on Viral Molecular Machines: Replication Systems within the Cores of dsRNAViruses (Elsevier), guest editor, 2004.
  • Finnish Academy of Science and Letters, member elected, 2002.
  • Societas Biochemica, Biophysica et Microbiologica Fenniae, president, 1999-2005.
  • UNESCO Associated Center of Excellence, Vilnius University, SAB member, 2000-2005.
  • Societas Biochemica, Biophysica et Microbiologica Fenniae, president, 1999-2005.
  • Board for Gene Technology (Competent Authority, EU), vice chairman 1995-1999.
  • Foundation for Biotechnical and Industrial Fermentation Research, Helsinki, executive committee member 1995-1998.
  • Faculty of Mathematics and Natural Sciences, UH, international evaluation committee member 1993, chairman 1994.
  • Maj and Tor Nessling Foundation, Finland, scientific advisory board, member 1988-1992, chairman 1992-1993.
  • Referee activity in Nature, Nature Reviews in Microbiology, Journal of Virology, Nucleic Acids Research,PNAS, EMBO Journal, Science, Molecular Cell, Cell, etc.
  • Several appointments as a pre-examiner or an opponent of doctoral dissertations in Finland and abroad.
  • Several appointments to evaluate academic competence (e.g. title of docent).
  • Appointments to evaluate ERC grant applications as an external expert (2017).
  • Major Institutional Responsibilities
  • Biocentrum Helsinki (University Center of Excellence), member, 1995- 2016.
  • Faculty of Biological and Environmental Sciences, UH, Finland, faculty council member, 2004-2009, 2012-2013.
  • Finnish Center of Excellence in Virus Research, director, 2006-2011.
  • Bio and Natural Sciences, UH, Finland, member of the fellowship fund board, 2004-2010.
  • Research Group Organization in Molecular Biosciences, UH, Finland, chairman, 2000-2006.
  • Program on Structural Virology, a National Center of Excellence, UH, Finland, director, 2000-2005.
  • Faculty of Mathematics and Natural Sciences, UH, Finland, faculty council member, 1992-1998.
  • Laboratory Animal Facility, UH, Finland, board member, 1994-1997.
  • Department of Electron Microscopy, UH, Finland, board member, 1992-1995.
  • Invited Oral presentations in international meetings since 2007
  • EMBL-RNA virus symposium, invited speaker, Heidelberg, Germany 6.3.2007
  • Symposium on Virology, Max-Planck-Gesellschaft, Berlin, Germany, invited speaker 12.4.2007.
  • Structure-Function Analysis of Viruses, Nantes, France, keynote speaker 31.5.2007.
  • Gordon conference on Structural, Functional and Evolutionary Genomics, Hingston, UK, invited speaker 29.7.2007.
  • VIZIER/EMBO workshop on RNA viruses: replication, evolution and drug design, Vienna, invited speaker 27.8. 2007.
  • Murnau Conference on Structural Biology, Murnau, Germany, plenary speaker 7.9.2007.
  • FASEB Conference on Virus Assembly, Saxtons River, USA, invited speaker 22.6.2008.
  • VIZIER/SPINE2 Workshop on Structural Virology, Vienna, invited speaker 14.6.2008.
  • 1st Sino-Finn Life Science Forum, Wuhan, China, invited speaker 26.10.2008.
  • 6th International Virus Assembly Symposium, Crete Greece, invited speaker 3.5.2009.
  • III Workshop on Structural Biology, Bilbao, Spain, Key note speaker, 4. 6. 2009.
  • 5th Smögen Summer Symposium on Virology, Smögen Sweden, keynote speaker, 22.8.2009.
  • EU COST Workshop on Plant Virus Control based on RNA based Vaccines, Helsinki, invited speaker, 12.9.2009.
  • Colloquium on Genome Structure, Function and Evolution, Orsay, France, keynote speaker, 5.12.2009.
  • Wuhan University, China, invited seminar 27.11.2009.
  • INSTRUCT workshop on correlative microscopy, Oxford University, invited speaker 13.1.2010.
  • Society for General Microbiology, UK annual meeting, Edinburgh, plenary speaker, 29.3.2010.
  • INSTRUCT annual meeting, DESY Hamburg, invited speaker, 29.4.2010.
  • ESF-EMBO Symposium on antiviral applications of RNA interference Sant Feliu, Spain, invited speaker 30.5.2010.
  • Conference on Viruses of Microbes, Institut Pasteur, Paris, invited speaker and program committee member, 21.6.2010.
  • 3rd Mathematical Virology Workshop, Ambleside, UK, invited speaker, 16.8.2010.
  • 20th Biocity Symposium, University of Turku, Finland, invited speaker, 20.8.2010.
  • 3rd Sino-Finn Life Science Forum, Shanghai, China, invited speaker, 30.10.2010.
  • Virology Symposium, Lund University, Sweden, keynote speaker, 14.3.2011.
  • Viruses of the Environment, Heidelberg, Germany, 22.3.2011.
  • British-Scandinavian meeting in Microbiology, Bergen, Norway, invited speaker, 26.5.2011.
  • Aquatic Virus Workshop AVW6 Texel, The Netherlands, invited speaker, 30.10.2011.
  • 5th Monolith Summer Symposium, Portoroz, Slovenia, invited speaker, 1.6.2012.
  • EMBO Meeting on Viruses of Microbes, Brussels, Belgium, keynote speaker, 16.7.2012.
  • XII Spanish National Congress on Virology, Burgos, Spain, invited speaker, 9.6.2013.
  • American Society for Virology annual meeting, Pennsylvania, USA, plenary speaker, 20.7.2013
  • 5th European Congress of Virology, Lyon, France, plenary speaker 11.9.2013.
  • Max Planck Institute, Heidelberg, Germany, invited speaker, 12.2.2014
  • Institut Pasteur, Paris, France, invited speaker, 5.3.2014
  • FASEB Summer Conference on Virus Assembly, Vermont, USA, keynote speaker, 29.6.2014
  • Viruses of Microbes, Zurich, Switzerland, invited speaker 14.7.2014
  • Extremophiles 2014, Saint Petersburg, invited speaker, 7.9.2014
  • Phages 2014, Oxford, UK, keynote speaker, 16.9.2014.
  • Physical Virology: From Structure to Evolution, Bilbao, Spain, plenary speaker, 9-11.3.2015
  • Phages 2015, Oxford, Great Britain, keynote speaker, 1-2.9.2015
  • International Symposium on Double-Stranded RNA Viruses, Goa, India, plenary speaker, 6-10.10.2015.
  • LUCA, its contemporaries and their viruses: 20 years after, Les Treilles, France, invited speaker, 9-14.5.2016.
  • Congress of Baltic Microbiologists, Vilnius, Lithuania, invited speaker, 18-21.10.2016.
  • Centennial Celebration of the Bacteriophage Research, Paris, France, invited speaker 24.4-26.4.2017
  • 1st German Phage Symposium, Stuttgart, Germany, keynote speaker, 9-11.10.2017

10. Scientific and societal impact of research

  • I have published well over 350 internationally peer reviewed articles some 35 of them have appeared in high impact journals (impact factors from about ten upwards). These include more than 20 reviews and close to 40 chapters in research books. These papers have been cited more than 9000 times and my h-index is 52 (web of science, August 2016).
  • Our biochemical and atomic-level studies on the dsRNA bacteriophage phi6 RNA-dependent RNA polymerase has led to patents (“RNA polymerases from bacteriophage PHI 6-PHI 14 and use of thereof”, WO 01/46396 A1, Priority: 1999-12-21 FI1999000002751, Patents: AU 785036 B2, NZ 519679 A, EP1242586 B1) and biotechnical applications in the field of RNA interference and such enzymes are globally available through Thermo Fisher Scientific Inc.

Tieteenalat

  • 1183 Kasvibiologia, mikrobiologia, virologia
  • 1182 Biokemia, solu- ja molekyylibiologia

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