Valokuva: Jukka Kallijärvi
  • Suomi

Hyväksyy tohtorikoulutettavat

20022019
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Henkilökohtainen profiili

Ansioluettelo

Curriculum vitae 07.09.2017

1. Personal information
• Name: Jukka Petri Kallijärvi
• Gender: male
• Date of Birth: 21.04.1973
• Citizenship: Finnish
• Current residence: Helsinki, Finland

2. Education and degrees
• Ph.D. University of Helsinki, Faculty of Medicine, medical genetics, 17.01.2006
• M.Sci. University of Helsinki, Faculty of Science, biochemistry, 07.05.1999
• Title of docent (cell and molecular biology), University of Helsinki, Faculty of Biological and Environmental Sciences, 16.08.2016

3. Linguistic skills
• Mother tongue Finnish
• Other languages: English (excellent skills), Swedish (good skills), German (elementary skills) and French (elementary skills)

4. Other training
• Vocational training in teamleadership (teamledarutbildning), 1.5 years, Rastor, 22.11.2016-Spring 2018
• Folkhälsan leadership training, 20-21.10.2015

5. Current appointment
• Senior researcher, co-principal investigator, Folkhälsan Research Center, prof. emerita Vineta Fellman’s group, 01.11.2012-

6. Previous appointments
• Visiting researcher, Lundin University, Swedem, prof. Vineta Fellman’s group, 01.02.2013-31.03.2013
• Postdoctoral researcher, University of Helsinki, Institute of Biotechnology, prof. Mart Saarma’s group, “Studies of mammalian and Drosophila GDNF receptors”, 01.02.2007-31.10.2012
• Postdoctoral researcher, University of Helsinki Institute of Biotechnology, Dr. Oscar Puig’s group, “Transcriptional regulation of insulin and insulin-like growth factor receptors in insulin resistance”, 01.03.2006-31.1.2007
• Ph.D student, Folkhälsan Research Center and University of Helsinki, Department of Medical Genetics, prof. Anna-Elina Lehesjoki’s group, “Molecular pathogenesis of mulibrey nanism”, 01.09.2000-28.2.2006
• Fellow of Helsinki Biomedical Graduate School, 01.01.2002-31.12.2005
• Master’s thesis student and research scientist, University of Helsinki, Department of Biosciences, Dr. Mathias Bergman’s group, “Phenotypic characterization of transgenic mice overexpressing C-terminal Src kinase in vascular endothelium”, 01.05.1998-30.09.2000
• Summer student, University of Helsinki, Institute of Biomedicine, Dr. Marc Baumann’s group, “Biochemistry of amyloidogenic peptides involved in Alzheimer’s disease and other amyloidoses”, 01.06.-31.08.1997

7. Research funding and supervision
• Current research funding
- Folkhälsan Research Center, full salary 1.1.2016-
- Prof. Fellman group funding: Folkhälsan Research Center, Swedish Research Council, Finska läkaresällskapet, Foundation for Pediatric Research in Finland
• Previous research funding
- Academy of Finland postdoctoral project 01.01.2008-31.12.2010
- Finnish cultural foundation, one-year grant for postdoctoral work, 2006
• Central role in writing of funding applications in Fellman’s group since 2013, including as main applicant (e.g. Aacademy of Finland, Juselius, Emil Aaltonen and United Mitochondial Disease Foundations).
• Supervision of postdoctoral researchers (together with prof. Fellman): Dr. Mubashir Hanif (Folkhälsan Research Center, 2012-13), Dr Saara Tegelberg (Lundin University and Folkhälsan Research Center, 2015-16), Dr. Kristiina Uusi-Rauva (Folkhälsan Research Center, 2015-16)
• Supervision of theses
- FM Vladislav Grigorjev, thesis project “The effect of a novel mitochondrial DNA variant in Bcs1l mutant mouse model”, Oct 2016-
- Ba.Nutr.Sci. Janne Purhonen, PhD thesis “Dietary and pharmacological interventions in mouse model of the mitochondrial hepatopathy GRACILE syndrome”, June 2014-
- M.Sci. Jayasimman Rajendran, PhD thesis project “Interventions to improve mitochondrial function in experimental models of GRACILE syndrome, a complex III assembly disorder”, Nov. 2013-
- Ba.Nutr.Sci. Janne Purhonen, master’s thesis ”Ketogeenisen ruokavalion vaikutus GRACILE-mitokondriotaudin hiirimallissa”, Dec. 2013-May 2014
- Kristel Virtanen, master’s thesis “DmRet mutanttialleelin tuottaminen kahden päällekkäisen FLP-deleetion avulla.”, 2012-13

8. Teaching positions and experience
Teaching positions
• Holding assistantship in biochemistry, University of Helsinki, Faculty of Biological and Environmental Sciences, Department of Biosciences, 01.08.-31.12.1998
Lectures & practical teaching
• Small animal models in biomedical research, Doctoral Program in Biomedicine practical course, full day lectures and teaching, 7.-11.12.2015
• Biotieteiden perusteet, Faculty of Biological and Environmental Sciences, Department of Biosciences, 4.5 hours of lectures, Oct-Nov 2015
• Solubiologia, Faculty of Biological and Environmental Sciences, Department of Biosciences, 4.5 hours of lectures, May 2015
• Molecular Biology of invertebrates: Introduction to the true model of genetics - Drosophila melanogaster, a practical course for master’s students, Tallinn Technical University, Institute of Gene Technology, full day lectures and lab teaching, 17.03. – 20.03.2015
• Mäkelänrinteen lukio, biologian soveltava kurssi kevät 2015 ja 2016 (teacher Arttu Ahola), planning of fruit fly crosses for the students, delivery of the required strains, media and vials
• ”Drosophila as an experimental model” demonstrations in developmental biology course for medical students annually
• Visit by Mattlidens Högstadieskola , Espoo, ”Drosophila as an experimental model” demonstrations to pupils
• Biomedicum campus day 18.3.2014, ”Drosophila as an experimental model” demonstrations to high school students

9. Scientific and societal impact of research
• Number of publications 22, citations 217, h index 9 (Scopus author ID: 6506024749)
• Post-PhD publications and their number of citations
1. Perea D, Guiu J, Hudry B, Konstantinidou C, Milona A, Hadjieconomou D, Carroll T, Hoyer N, Natarajan D, Kallijärvi J, Walker JA, Soba P, Thapar N, Burns AJ, Jensen KB, Miguel‐Aliaga I. Ret receptor tyrosine kinase sustains proliferation and tissue maturation in intestinal epithelia. EMBO J. Sep 12. pii: e201696247 (2017)
2. Saarenpää T, Kogan K, Sidorova Y, Mahato AK, Tascón I, Kaljunen H, Yu L, Kallijärvi J, Jurvansuu J, Saarma M, Goldman A. Zebrafish GDNF and its co-receptor GFRα1 activate the human RET receptor and promote the survival of dopaminergic neurons in vitro. PLoS One 12(5):e0176166 (2017)
3. Purhonen J, Rajendran J, Uusi-Rauva K, Katayama S, Krjutskov K, Einarsdottir E, Velapugi V, Kere J, Jauhiainen M, Fellman V, Kallijärvi J. Ketogenic diet attenuates hepatopathy in mouse model of respiratory chain complex III deficiency caused by a Bcs1l mutation. Sci Rep 7(1):957 (2017)
4. Tegelberg S, Tomašić N, Kallijärvi J, Purhonen J, Elmér E, Lindberg E, Nord DG, Soller M, Lesko N, Wedell A, Bruhn H, Freyer C, Stranneheim H, Wibom R, Nennesmo I, Wredenberg A, Eklund EA, Fellman V. Respiratory chain complex III deficiency due to mutated BCS1L: a novel phenotype with encephalomyopathy, partially phenocopied in a Bcs1l mutant mouse model. Orphanet J Rare Dis 12(1):73 (2017)
5. Davoudi M, Kotarsky H, Hanson E, Kallijärvi J, Fellman V. Supercomplex formation is modified by SCAF1/COX7A2l assembly factor and pre-complex III in different mouse strains with a homozygous Bcs1l mutation. PLoS One 11(12):e0168774 (2016) (1 citation)
6. Rajendran J, Tomašić N, Kotarsky H, Hansson E, Velagapudi V, Kallijärvi J, Fellman V. Effect of high-carbohydrate diet on plasma metabolome in mice with mitochondrial respiratory chain complex III deficiency. Int J Mol Sci. 17(11). pii: E1824 (2016)
7. Lindström R, Lindholm P, Kallijärvi J, Palgi M, Saarma M, Heino TI. Exploring the conserved role of MANF in unfolded protein response in Drosophila melanogaster. PLoS One 11(3):e0151550 (2016) (2 citations)
8. Weinheimer I, Jiu Y, Rajamäki ML, Matilainen O, Kallijärvi J, Cuellar WJ, Lu R, Saarma M, Holmberg CI, Jäntti J, Valkonen JP. (2015) Suppression of RNAi by dsRNA-degrading RNaseIII enzymes of viruses in animals and plants. PLoS Pathog. 11(3):e1004711 (2015) (7 citations)
9. Davoudi M, Kallijärvi J, Marjavaara S, Kotarsky H, Hanson E, Levéen P, Fellman V. A mouse model of mitochondrial complex III dysfunction induced by myxothiazol. Biochem Biophys Res Commun 446(4):1079-84 (2014) (2 citations)
10. Lindström R, Lindholm P, Li-ying Y, Kallijärvi J, Arumäe U, Saarma M and Heino TI. Characterization of the structural determinants of MANF function using Drosophila in vivo model. PLoS One 8(9): e73928 (2013) (13 citations)
11. Kallijärvi J, Stratoulias V, Virtanen K, Hietakangas V, Heino TI and Mart Saarma. Characterization of Drosophila GDNF receptor-like and evidence for its evolutionarily conserved interaction with Neural Cell Adhesion Molecule (NCAM)/FasII. PLoS One 7(12):e51997 (2012) (6 citations)
12. Karlberg S, Lipsanen-Nyman M, Lassus H, Kallijärvi J, Lehesjoki AE, Butzow R. Gynecological tumors in Mulibrey nanism and role for RING finger protein TRIM37 in the pathogenesis of ovarian fibrothecomas. Mod Pathol 22(4):570-8 (2009) (9 citations)
13. Mattila J, Kallijärvi J, Puig O. RNAi screening for kinases and phosphatases identifies FoxO regulators. Proc Natl Acad Sci USA 105(39):14873-8 (2008) (31 citations)

10. Other merits
• Founding member and first chair of Institute of Biotehcnology Postdoc association, 2011-12
• Member of Folkhälsan Research Center operational board, Oct. 2016-

Asemat yliopiston ulkopuolella

Senior researcher, Folkhalsan Res Ctr, Folkhalsan Inst Genet, Biomedicum

1 marraskuuta 2012 → …

Tieteenalat

  • 3111 Biolääketieteet
  • 1184 Genetiikka, kehitysbiologia, fysiologia

Kansainvälinen ja kotimainen yhteistyö Viimeisin maatasolla toteutettu yhteistyö. Saat syvempiä lisätietoja pisteitä napsauttamalla.

Julkaisut 2002 2019

  • 17 Artikkeli
  • 1 Kirjan luku tai artikkeli
  • 1 Pääkirjoitus
  • 1 Väitöskirja

Alternative oxidase-mediated respiration prevents lethal mitochondrial cardiomyopathy

Rajendran, J., Purhonen, J., Tegelberg, S., Smolander, O-P., Mörgelin, M., Rozman, J., Gailus-Durner, V., Fuchs, H., de Angelis, M. H., Auvinen, P., Mervaala, E., Jacobs, H. T., Szibor, M., Fellman, V. & Kallijärvi, J., tammikuuta 2019, julkaisussa : EMBO molecular medicine. 11, 1, 19 Sivumäärä, 9456.

Tutkimustuotos: ArtikkelijulkaisuArtikkeliTieteellinenvertaisarvioitu

Open access
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Rapamycin - "One size does not fit all"

Kallijarvi, J. & Fellman, V., huhtikuuta 2019, julkaisussa : EBioMedicine. 42, s. 30-31 2 Sivumäärä

Tutkimustuotos: ArtikkelijulkaisuPääkirjoitusTieteellinen

Open access
Tiedosto

NAD(+) repletion produces no therapeutic effect in mice with respiratory chain complex III deficiency and chronic energy deprivation

Purhonen, J., Rajendran, J., Tegelberg, S., Smolander, O-P., Pirinen, E., Kallijärvi, J. & Fellman, V., marraskuuta 2018, julkaisussa : FASEB Journal. 32, 11, s. 5913-5926 14 Sivumäärä

Tutkimustuotos: ArtikkelijulkaisuArtikkeliTieteellinenvertaisarvioitu

Ret receptor tyrosine kinase sustains proliferation and tissue maturation in intestinal epithelia

Perea, D., Guiu, J., Hudry, B., Konstantinidou, C., Milona, A., Hadjieconomou, D., Carroll, T., Hoyer, N., Natarajan, D., Kallijärvi, J., Walker, J. A., Soba, P., Thapar, N., Burns, A. J., Jensen, K. B. & Miguel-Aliaga, I., 16 lokakuuta 2017, julkaisussa : EMBO Journal. 36, 20, s. 3029-3045 17 Sivumäärä

Tutkimustuotos: ArtikkelijulkaisuArtikkeliTieteellinenvertaisarvioitu

Open access
Tiedosto

Zebrafish GDNF and its co-receptor GFR alpha 1 activate the human RET receptor and promote the survival of dopaminergic neurons in vitro

Saarenpää, T., Kogan, K., Sidorova, Y., Mahato, A. K., Tascon, I., Kaljunen, H., Yu, L., Kallijärvi, J., Jurvansuu, J., Saarma, M. & Goldman, A., 3 toukokuuta 2017, julkaisussa : PLoS One. 12, 5, 18 Sivumäärä, 0176166.

Tutkimustuotos: ArtikkelijulkaisuArtikkeliTieteellinenvertaisarvioitu

Open access
Tiedosto