Valokuva Maija Sierla

Maija Sierla

Academy Research Fellow, Principal Investigator

  • PL 65 (Viikinkaari 1)

    00014

    Suomi

20132018

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Tutkimuksen ja opetuksen kuvaus

My research group studies the molecular basis of stomatal function. We aim to decipher the molecular mechanisms through which guard cells sense and respond to changing environmental conditions. We also study vascular water transport and aim to identify molecular components through which stomatal function and regulation of water transport are connected and coordinated.

Stomata are formed on the leaf surface by two surrounding guard cells and simultaneously regulate and balance water loss with the uptake of carbon dioxide necessary for photosynthesis. Stomata are a primary site of interaction of the plant with its environment and have developed mechanisms to sense and respond to changing conditions.  We have shown that the leucine-rich receptor-like kinase (LRR-RLK) GHR1 is a central regulator of stomatal closure. GHR1 is a pseudokinase that activates the guard cell anion channel SLAC1 and acts in stomatal closure through scaffolding functions rather than direct phosphorylation of target proteins.

Given the severity and pervasive nature of stomatal phenotypes in ghr1 mutant plants, GHR1 may be an integration point where diverse endogenous and environmental signals converge to regulate components required for rapid stomatal closure. We have identified multiple novel interactors of GHR1, including channel proteins, transporters and LRR-RLKs. We aim to characterize these novel components and the mechanistic details of the interactions in order to further our understanding of the signaling networks that regulate stomatal function.

Although stomatal function must be intricately linked to the transport of water at the whole plant level, research combining these two processes, and especially knowledge of the molecular components involved, is lacking. We have shown that GHR1 regulates water transport in the vasculature and identified interactors that may facilitate this function. Further characterization of these molecular interactions will shed light on how stomatal function and regulation of water transport are connected at the level of the whole plant.

I teach plant molecular biology and plant biotechnology.

Ansioluettelo

CV, MAIJA SIERLA, 21.08.2020

 

PERSONAL DETAILS

Full name: Sierla, Maija Elina

ORCID Identifier: 0000-0002-8493-3582

Nationality: Finnish

 

EDUCATION AND DEGREES COMPLETED

2006-2011 Imperial College London, London, United Kingdom

Doctor of Philosophy (PhD), Molecular plant biology

 

2005-2006 University of Helsinki, Faculty of Biosciences, Helsinki, Finland

Master of Science in December 2006

 

1998-2002 University of East Anglia, Norwich, United Kingdom

Bachelor of Science with Honours in Biological Sciences

 

SECURED POSITION

2020-2025 University of Helsinki, Faculty of Biological and Environmental Sciences

Academy Research Fellow, Principal Investigator

Period of employment: 01.09.2020-31.08.2025

 

CURRENT POSITION

2018-2020 University of Helsinki, Faculty of Biological and Environmental Sciences

Researcher

Period of employment: 01.07.2018-31.08.2020

Funded by personal grants from the Finnish Cultural Foundation and the Ella and Georg Ehrnrooth Foundation and Academy of Finland Centre of Excellence Funding to Jaakko Kangasjärvi

                                      

PREVIOUS WORK EXPERIENCE

2011-2018 University of Helsinki, Faculty of Biological and Environmental Sciences

Post-doctoral researcher in the group of Prof Jaakko Kangasjärvi

Period of employment: 17.10.2011-30.06.2018

Funded by a 2-year personal grant for post-doctoral research from Ella and Georg Ehrnrooth Foundation and Academy of Finland project and Centre of Excellence funding to Prof Kangasjärvi

 

2013 Helmholz Zentrum, Munich, Germany

Visiting post-doctoral researcher for six weeks in the ExpoScreen facility

 

2006-2011 Imperial College London, London, United Kingdom

Doctor of Philosophy (PhD) student in the group of Dr Bart Feys in Life Sciences Doctoral Training Program, funded by Biotechnology and Biological Sciences Research Council (3 years) and Ella and Georg Ehrnrooth foundation (1 year)  

 

03/2010 University of Durham, Durham, United Kingdom

Visiting PhD student in Prof Marc Knight’s laboratory

 

2002-2005 Sainsbury Laboratory, Norwich, United Kingdom

Research Assistant in Dr John Rathjen’s laboratory

 

2000-2001 Sainsbury Laboratory, Norwich, United Kingdom

Research Technician in Dr Anne Osbourn’s laboratory

 

CAREER BREAKS

On maternity leave March 2019 – February 2020

On maternity leave October 2016 – August 2017

On maternity leave March 2014 – January 2015

 

PERSONAL RESEARCH FUNDING AND GRANTS

2020 Academy of Finland

Academy Research Fellow, Principal Investigator Dr Sierla (€940 000)

Project: GHR1 and its interactors in stomatal movements and water transport in the vasculature

Funding period: 01.09.2020 - 31.08.2025

 

2020 Ella and Georg Ehrnrooth Foundation

Grant (€4500) for a two-month research visit to a collaborator’s laboratory in France

 

2019 Ella and Georg Ehrnrooth Foundation

One-year researcher grant (€31 000)

 

2018 Ella and Georg Ehrnrooth Foundation

Grant (€2000) for organizing a workshop on guard cell signalling at the International Conference on Arabidopsis Research 2018 conference

 

2016 Finnish Cultural Foundation

One-year researcher grant (€28 000)

 

2011-2013 Ella and Georg Ehrnrooth Foundation

Two-year grant (€44 000) for post-doctoral research

Funding period: 17.10.2011-16.10.2013       

 

2012 University of Helsinki, Chancellor’s Grant

Travel grant for attending the 29th New Phytologist Symposium

 

2009-2010 Ella and Georg Ehrnrooth Foundation

One-year grant for completion the Doctoral thesis (€16 000)

 

2009 Gregory Fund

Travel grant for attending the 20th International Conference on Arabidopsis Research

 

2006-2009 Biotechnology and Biological Sciences Research Council

Three year Doctoral training grant (€53 300)

 

2002 North-Karelian Division of the Finnish Cultural Foundation

Grant supporting the final year studies of my BSc degree

 

TEACHING TRAINING

University Pedagogy courses (University of Helsinki)

Constructive Alignment in Course Design, 5 credits (YP 2.1 Opetuksen linjakas suunnittelu, toteutus ja arviointi)

Learning in Higher Education, 5 credits (YP1 Oppiminen yliopistossa)

Workshop for Graduate Teaching Assistants (Imperial College London)

 

TEACHING EXPERIENCE

Lecturer and teacher at Current Challenges in Plant Biology 2017 (DPPS-501)

Course was organized by the Doctoral Programme in Plant Sciences, University of Helsinki

Graduate teaching assistant for the undergraduate course: Applied Molecular Biology, 2007-2009

Course was organized by the Division of Biology in the Faculty of Natural Sciences of Imperial College London

Graduate teaching assistant for the undergraduate course: Virology, 2007-2009

Course was organized by the Division of Biology in the Faculty of Natural Sciences of Imperial College London

 

LEADERSHIP AND SUPERVISION EXPERIENCE

2006-2019 Supervision experience

Primary supervisor for the MSc thesis of Anna Huusari (2016-2018), University of Helsinki

Secondary supervisor for the thesis of five MSc/MRes students, three BSc students and one Erasmus exchange student, Imperial College London

Mentoring and supervisory duties for post-docs, PhD students and research assistants, University of Helsinki

 

EXPERIENCE OF ORGANIZING SCIENTIFIC MEETINGS

25-29.06.2018, International Conference on Arabidopsis Research (ICAR). The main organizer and chair for a workshop entitled ‘Perception of stress and CO2 in guard cells’ at ICAR2018. Prof Hannes Kollist was a co-organizer.

21-25.06.2021, Organization of mini-symposium entitled ‘How do plants sense and respond to elevated carbon dioxide, ozone and drought?’ for ICAR2021, main organizer and chair Maija Sierla, co-organizer Prof Julian Schroeder.

 

OTHER KEY SCIENTIFIC OR ACADEMIC MERITS

Oral presentation at the International Conference on Arabidopsis Research (ICAR),Turku, Finland, June 2018.

Oral Presentation at Current Challenges in Plant Biology: Redox Regulation, Helsinki, Finland, December 2017.

Oral presentation at International Workshop on Plant Membrane Biology, Annapolis, USA, June 2016.

Oral presentation at VISCEA Plant Abiotic Stress Tolerance III Conference,Vienna, Austria, June 2015.

Referee for scientific journals:  New Phytologist

Hõrak, Sierla et al., 2016, was selected by The Plant Cell as ‘Best of 2016: Top Topics in The Plant Cell journal’

Post-doc representative for the ‘Centre of Excellence in Molecular Biology of Primary Producers’ application process

Koulutus / tieteellinen pätevyys

Molecular plant biology, Doctor of Philosophy, Imperial College London

20062011

Myöntöpäivä: 1 maaliskuuta 2011

Biology, Genetics, Master of Science, Helsingin yliopisto

20052006

Myöntöpäivä: 18 elokuuta 2006

Biological Sciences, Bachelor of Science, University of East Anglia

19982002

Myöntöpäivä: 14 kesäkuuta 2002

Tieteenalat

  • 1183 Kasvibiologia, mikrobiologia, virologia
  • 1184 Genetiikka, kehitysbiologia, fysiologia
  • 1182 Biokemia, solu- ja molekyylibiologia

Kansainvälinen ja kotimainen yhteistyö Viimeisin maatasolla toteutettu yhteistyö. Saat syvempiä lisätietoja pisteitä napsauttamalla.

Julkaisut

  • 4 Artikkeli
  • 1 Ensyklopedia-artikkeli
  • 1 Katsausartikkeli

The receptor-like pseudokinase GHR1 is required for stomatal closure

Sierla, M. E., Hõrak, H., Overmyer, K. L., Waszczak, C. M., Yarmolinsky, D., Maierhofer, T., Vainonen, J., Denessiouk, K., Salojärvi, J. T., Laanemets, K., Tõldsepp, K., Vahisalu, T., Gauthier, A. G. B., Puukko, T., Paulin, L., Auvinen, P. O. V., Geiger, D., Hedrich, R., Kollist, H. & Kangasjärvi, J. S., marraskuuta 2018, julkaisussa : Plant Cell. 30, 11, s. 2813-2837 25 Sivumäärä

Tutkimustuotos: ArtikkelijulkaisuArtikkeliTieteellinenvertaisarvioitu

Open access

Genome sequencing and population genomic analyses provide insights into the adaptive landscape of silver birch

Salojärvi, J., Smolander, O-P., Nieminen, K., Rajaraman, S., Safronov, O., Safdari, P., Lamminmäki, A., Immanen, J., Lan, T., Tanskanen, J., Rastas, P., Amiryousefi, A., Jayaprakash, B., Kammonen, J. I., Hagqvist, R., Eswaran, G., Ahonen, V. H., Serra, J. A., Asiegbu, F. O., Barajas-Lopez, J. D. D. & 65 muuta, Blande, D., Blokhina, O., Blomster, T., Broholm, S., Brosche, M., Cui, F., Dardick, C., Ehonen, S. E., Elomaa, P., Escamez, S., Fagerstedt, K. V., Fujii, H., Gauthier, A., Gollan, P. J., Halimaa, P., Heino, P. I., Himanen, K., Hollender, C., Kangasjarvi, S., Kauppinen, L., Kelleher, C. T., Kontunen-Soppela, S., Koskinen, J. P., Kovalchuk, A., Karenlampi, S. O., Kärkönen, A. K., Lim, K-J., Leppälä, J., Macpherson, L., Mikola, J., Mouhu, K., Mähönen, A. P., Niinemets, U., Oksanen, E., Overmyer, K., Palva, E. T., Pazouki, L., Pennanen, V., Puhakainen, T., Poczai, P., Possen, B. J. H. M., Punkkinen, M., Rahikainen, M. M., Rousi, M., Ruonala, R., van der Schoot, C., Shapiguzov, A., Sierla, M., Sipilä, T. P., Sutela, S., Teeri, T. H., Tervahauta, A. I., Vaattovaara, A., Vahala, J., Vetchinnikova, L., Welling, A., Wrzaczek, M., Xu, E., Paulin, L. G., Schulman, A. H., Lascoux, M., Albert, V. A., Auvinen, P., Helariutta, Y. & Kangasjarvi, J., 8 toukokuuta 2017, julkaisussa : Nature Genetics. 49, 6, s. 904-912 12 Sivumäärä

Tutkimustuotos: ArtikkelijulkaisuArtikkeliTieteellinenvertaisarvioitu

Open access
Tiedosto

Ozone and Reactive Oxygen Species

Krasensky-Wrzaczek, J., Carmody, M., Sierla, M. E. & Kangasjärvi, J. S., 20 maaliskuuta 2017, Encyclopedia of Life Sciences. Wiley Online Library, s. 1-9

Tutkimustuotos: Artikkeli kirjassa/raportissa/konferenssijulkaisussaEnsyklopedia-artikkeliTieteellinenvertaisarvioitu

A Dominant Mutation in the HT1 Kinase Uncovers Roles of MAP Kinases and GHR1 in CO2-Induced Stomatal Closure

Horak, H., Sierla, M., Toldsepp, K., Wang, C., Wang, Y-S., Nuhkat, M., Valk, E., Pechter, P., Merilo, E., Salojärvi, J., Overmyer, K., Loog, M., Brosche, M., Schroeder, J. I., Kangasjärvi, J. & Kollist, H., lokakuuta 2016, julkaisussa : Plant Cell. 28, 10, s. 2493-2509 17 Sivumäärä

Tutkimustuotos: ArtikkelijulkaisuArtikkeliTieteellinenvertaisarvioitu

Open access

Reactive Oxygen Species in the Regulation of Stomatal Movements

Sierla, M., Waszczak, C., Vahisalu, T. & Kangasjärvi, J., heinäkuuta 2016, julkaisussa : Plant Physiology. 171, 3, s. 1569-1580 12 Sivumäärä

Tutkimustuotos: ArtikkelijulkaisuArtikkeliTieteellinenvertaisarvioitu

Open access

Aktiviteetit

  • 4 Suullinen esitys
  • 3 Konferensseihin, kursseille ja seminaareihin osallistuminen ja näiden järjestäminen
  • 1 Tyypit: Muut aktiviteetit - Muut

International Conference on Arabidopsis Research 2018

Maija Sierla (Puhuja: puheenjohtaja)

25 kesäkuuta 201829 kesäkuuta 2018

Aktiviteetti: Tapahtumaan osallistumisen ja tapahtuman järjestämisen tyypitKonferensseihin, kursseille ja seminaareihin osallistuminen ja näiden järjestäminen

The receptor-like pseudokinase GHR1 regulates stomatal closure

Maija Sierla (Puhuja)

25 kesäkuuta 201829 kesäkuuta 2018

Aktiviteetti: Puhe- tai esitystyypitSuullinen esitys

The receptor-like pseudokinase GHR1 regulates stomatal closure

Maija Sierla (Puhuja)

11 joulukuuta 201712 joulukuuta 2017

Aktiviteetti: Puhe- tai esitystyypitSuullinen esitys

An atypical LRR-receptor-like kinase regulates stomatal closure

Maija Sierla (Puhuja)

5 kesäkuuta 201610 kesäkuuta 2016

Aktiviteetti: Puhe- tai esitystyypitSuullinen esitys

Atypical receptor kinase RCD7 is a central regulator of stomatal function

Maija Sierla (Puhuja)

29 kesäkuuta 20151 heinäkuuta 2015

Aktiviteetti: Puhe- tai esitystyypitSuullinen esitys