Chemical biology -oriented studies to identify means for resuscitating persistent Chlamydia pneumoniae infections to antibiotics. The project aims to the discovery of polypharmacological approaches for adjuvant therapies against the long-lasting chlamydial infections.
Chlamydia pneumoniae is a human respiratory pathogen that is prone to treatment failures. The primary reason for this is the bacterium's propensity to confer into a dormant, metabolically altered state known as persistence. In this project, we aim to find new treatment strategies to improve the sensitivity of chlamydial infections to antibiotics. The work focuses on identification of chemosensitizing small molecules and studying their molecular targets.