Epigenome Activated Proteostasis

This project aims to elucidate epigenetic factors that regulate protein homeostasis. Furthermore, the aim is to study whether identified epigenetic mechanisms can be pharmacologically activated in order to rejuvenate the deteriorated epigenome upon aging, and thereby, to prevent proteotoxic maladies and to promote health span.

This project aims to elucidate how mechanisms that maintain the function and organisation of the genome regulate aging and the onset of aging-associated maladies. The focus is to find genome-regulating factors that contribute to health span by affecting the homeostasis of cellular proteome.