The Diabetes Epidemiology: Collaborative analysis of Diagnostic criteria in Europe (the DECODE) and in Asia (the DECODA) (DECODE/DECODA)

  • Qiao, Qing (Vastuullinen tutkija)
  • Tuomilehto, Jaakko (Vastuullinen tutkija)
  • Sintonen, Harri (Vastuullinen tutkija)
  • Nyamdorj, Regzedmaa (Osallistuja)
  • Hyvärinen, Marjukka (Osallistuja)
  • Nan, Hairong (Osallistuja)
  • Gao, Weiguo (Osallistuja)
  • Zhang, Lei (Osallistuja)
  • Zhou, Xianghai (Osallistuja)
  • Ning, Feng (Osallistuja)
  • Song, Xin (Osallistuja)
  • Zhang, Yanlei (Osallistuja)

Projektin yksityiskohdat

Kuvaus

The Diabetes Epidemiology: Collaborative analysis Of Diagnostic criteria in Europe (the DECODE) and in Asia (the DECODA) studies are two largest epidemiological studies on hyperglycemia and other metabolic disorders in the world, comprising more than 60 cohorts of mainly population-based from 24 countries in Europe and Asia, with about 84000 Europeans and 84207 Asians of Chinese, Japanese, Indians, Mongolians and Philippines currently included in the collaboration. 2-hour 75g oral glucose tolerance test is available for all participants together with many other laboratory and anthropometric measures. Therefore, the databases are extremely valuable for studying diabetes and metabolic disorders.

With the primary objectives to evaluate the impacts of the changes in diagnostic criteria for diabetes in 1997 the two studies have already had a major impact on the current understanding of the importance of fasting and post-challenge glucose in public health and clinical research and practice. Our results have unequivocally shown that non-diabetic glucose levels such as the category of impaired glucose tolerance is an independent risk factor for CVD morbidity and mortality and the increased risk cannot be explained by the development of diabetes during the follow-up. The DECODE study had forced the WHO Consultation Group to revise their recommendations on the diagnostic criteria and resulted in a call for a new ADA Expert Committee on Classification and Diagnostic Criteria for Diabetes in 2001 with the updated report in 2003. The importance of post-load hyperglycaemia pointed by the DECODE study was addressed by the new ADA Expert Committee. We have also served the international organizations such as the WHO and the IDF by providing data and expertise for making definitions for diabetes, obesity and metabolic syndrome.
Recently, we have expanded our research to obesity, metabolic syndrome and cancer. In addition, we have started pioneering research projects on primary intervention of diabetes in real life setting in low- and middle-income countries.

All these have created an international research environment for doctorial training and teaching.

Responsible person: Qing Qiao, Department of Public Health

Participation category: 4
TilaKäynnissä
Todellinen alku/loppupvm28/02/1997 → …

Tieteenalat

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