A Novel Small Molecule GDNF Receptor RET Agonist, BT13, Promotes Neurite Growth from Sensory Neurons in Vitro and Attenuates Experimental Neuropathy in the Rat

Yulia A. Sidorova, Maxim M. Bespalov, Agnes W. Wong, Oleg Kambur, Viljami Jokinen, Tuomas O. Lilius, Ilida Suleymanova, Gunnar Karelson, Pekka V. Rauhala, Mati Karelson, Peregrine B. Osborne, Janet R. Keast, Eija A. Kalso, Mart Saarma

Tutkimustuotos: ArtikkelijulkaisuArtikkeliTieteellinenvertaisarvioitu

Alkuperäiskielienglanti
Artikkeli365
LehtiFrontiers in Pharmacology
Vuosikerta8
Sivumäärä18
ISSN1663-9812
DOI - pysyväislinkit
TilaJulkaistu - 21 kesäkuuta 2017
OKM-julkaisutyyppiA1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä, vertaisarvioitu

Tieteenalat

  • 317 Farmasia
  • 1182 Biokemia, solu- ja molekyylibiologia

Lainaa tätä

@article{b1488532132e4578b8ace3e636eebf3c,
title = "A Novel Small Molecule GDNF Receptor RET Agonist, BT13, Promotes Neurite Growth from Sensory Neurons in Vitro and Attenuates Experimental Neuropathy in the Rat",
keywords = "neuropathic pain, glial cell line-derived neurotrophic factor (GDNF), GDNF family ligands (GFLs), artemin (ARTN), small molecule RET agonist, GFL mimetic, GDNF family receptor alpha (GFR alpha), receptor tyrosine kinase RET, SPINAL NERVE LIGATION, NEUROTROPHIC FACTOR, SYSTEMIC ARTEMIN, FAMILY LIGANDS, DRG NEURONS, C-RET, PAIN, INJURY, NGF, SUBPOPULATIONS, 317 Pharmacy, 1182 Biochemistry, cell and molecular biology",
author = "Sidorova, {Yulia A.} and Bespalov, {Maxim M.} and Wong, {Agnes W.} and Oleg Kambur and Viljami Jokinen and Lilius, {Tuomas O.} and Ilida Suleymanova and Gunnar Karelson and Rauhala, {Pekka V.} and Mati Karelson and Osborne, {Peregrine B.} and Keast, {Janet R.} and Kalso, {Eija A.} and Mart Saarma",
year = "2017",
month = "6",
day = "21",
doi = "10.3389/fphar.2017.00365",
language = "English",
volume = "8",
journal = "Frontiers in Pharmacology",
issn = "1663-9812",
publisher = "Frontiers Media",

}

A Novel Small Molecule GDNF Receptor RET Agonist, BT13, Promotes Neurite Growth from Sensory Neurons in Vitro and Attenuates Experimental Neuropathy in the Rat. / Sidorova, Yulia A.; Bespalov, Maxim M.; Wong, Agnes W.; Kambur, Oleg; Jokinen, Viljami; Lilius, Tuomas O.; Suleymanova, Ilida; Karelson, Gunnar; Rauhala, Pekka V.; Karelson, Mati; Osborne, Peregrine B.; Keast, Janet R.; Kalso, Eija A.; Saarma, Mart.

julkaisussa: Frontiers in Pharmacology, Vuosikerta 8, 365, 21.06.2017.

Tutkimustuotos: ArtikkelijulkaisuArtikkeliTieteellinenvertaisarvioitu

TY - JOUR

T1 - A Novel Small Molecule GDNF Receptor RET Agonist, BT13, Promotes Neurite Growth from Sensory Neurons in Vitro and Attenuates Experimental Neuropathy in the Rat

AU - Sidorova, Yulia A.

AU - Bespalov, Maxim M.

AU - Wong, Agnes W.

AU - Kambur, Oleg

AU - Jokinen, Viljami

AU - Lilius, Tuomas O.

AU - Suleymanova, Ilida

AU - Karelson, Gunnar

AU - Rauhala, Pekka V.

AU - Karelson, Mati

AU - Osborne, Peregrine B.

AU - Keast, Janet R.

AU - Kalso, Eija A.

AU - Saarma, Mart

PY - 2017/6/21

Y1 - 2017/6/21

KW - neuropathic pain

KW - glial cell line-derived neurotrophic factor (GDNF)

KW - GDNF family ligands (GFLs)

KW - artemin (ARTN)

KW - small molecule RET agonist

KW - GFL mimetic

KW - GDNF family receptor alpha (GFR alpha)

KW - receptor tyrosine kinase RET

KW - SPINAL NERVE LIGATION

KW - NEUROTROPHIC FACTOR

KW - SYSTEMIC ARTEMIN

KW - FAMILY LIGANDS

KW - DRG NEURONS

KW - C-RET

KW - PAIN

KW - INJURY

KW - NGF

KW - SUBPOPULATIONS

KW - 317 Pharmacy

KW - 1182 Biochemistry, cell and molecular biology

U2 - 10.3389/fphar.2017.00365

DO - 10.3389/fphar.2017.00365

M3 - Article

VL - 8

JO - Frontiers in Pharmacology

JF - Frontiers in Pharmacology

SN - 1663-9812

M1 - 365

ER -