Accelerometer-based automatic voice onset detection in speech mapping with navigated repetitive transcranial magnetic stimulation

Anne-Mari Vitikainen, Elina Mäkelä, Pantelis Lioumis , Veikko Jousmäki, Jyrki P. Mäkelä

Tutkimustuotos: ArtikkelijulkaisuArtikkeliTieteellinenvertaisarvioitu

Abstrakti

Background: The use of navigated repetitive transcranial magnetic stimulation (rTMS) in mapping of speech-related brain areas has recently shown to be useful in preoperative workflow of epilepsy and tumor patients. However, substantial inter- and intraobserver variability and non-optimal replicability of the rTMS results have been reported, and a need for additional development of the methodology is recognized. In TMS motor cortex mappings the evoked responses can be quantitatively monitored by electromyographic recordings; however, no such easily available setup exists for speech mappings.
New Method: We present an accelerometer-based setup for detection of vocalization-related larynx vibrations combined with an automatic routine for voice onset detection for rTMS speech mapping applying naming.
Comparison with Existing Method(s): The results produced by the automatic routine were compared with the manually reviewed video-recordings.
Results: The new method was applied in the routine navigated rTMS speech mapping for 12 consecutive patients during preoperative workup for epilepsy or tumor surgery. The automatic routine correctly detected 96% of the voice onsets, resulting in 96% sensitivity and 71% specificity. Majority (63%) of the misdetections were related to visible throat movements, extra voices before the response, or delayed naming of the previous stimuli. The no-response errors were correctly detected in 88% of events.
Conclusion: The proposed setup for automatic detection of voice onsets provides quantitative additional data for analysis of the rTMS-induced speech response modifications. The objectively defined speech response latencies increase the repeatability, reliability and stratification of the rTMS results.
Alkuperäiskielienglanti
LehtiJournal of Neuroscience Methods
Vuosikerta253
Sivut70-77
Sivumäärä7
ISSN0165-0270
DOI - pysyväislinkit
TilaJulkaistu - 2015
OKM-julkaisutyyppiA1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä, vertaisarvioitu

Tieteenalat

  • 3126 Kirurgia, anestesiologia, tehohoito, radiologia
  • 1182 Biokemia, solu- ja molekyylibiologia
  • 3112 Neurotieteet

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