Accumulation of Lewy-Related Pathology Starts in Middle Age: The Tampere Sudden Death Study

Eloise H. Kok; Anders Paetau; Mika Martiskainen; Leo-Pekka Lyytikäinen; Terho Lehtimäki; Pekka Karhunen; Liisa Myllykangas

doi:10.1002/ana.26912

Accumulation of Lewy-Related Pathology Starts in Middle Age: The Tampere Sudden Death Study

Eloise H. Kok, Anders Paetau, Mika Martiskainen, Leo-Pekka Lyytikäinen, Terho Lehtimäki, Pekka Karhunen, Liisa Myllykangas

Tutkimustuotos: Artikkelijulkaisu › Artikkeli › Tieteellinen › vertaisarvioitu

Abstrakti

When effective treatments against neurodegenerative diseases become a reality, it will be important to know the age these pathologies begin to develop. We investigated alpha-synuclein pathology in brain tissue of the Tampere Sudden Death Study—unselected forensic autopsies on individuals living outside hospital institutions in Finland. Of 562 (16–95 years) participants, 42 were positive for Lewy-related pathology (LRP). The youngest LRP case was aged 54 years, and the frequency of LRP in individuals aged ≥50 years was 9%. This forensic autopsy study indicates LRP starts already in middle age and is more common than expected in the ≥50 years-of-age non-hospitalized population. ANN NEUROL 2024;95:843–848.

Alkuperäiskieli	englanti
Lehti	Annals of Neurology
Vuosikerta	95
Numero	5
Sivut	843-848
Sivumäärä	6
ISSN	0364-5134
DOI - pysyväislinkit	https://doi.org/10.1002/ana.26912
Tila	Julkaistu - toukok. 2024
OKM-julkaisutyyppi	A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä, vertaisarvioitu

Lisätietoja

Publisher Copyright:
© 2024 The Authors. Annals of Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association.

Tieteenalat

3124 Neurologia ja psykiatria

Pääsy asiakirjaan

10.1002/ana.26912

Annals of Neurology - 2024 - Kok - Accumulation of Lewy‐Related Pathology Starts in Middle Age The Tampere Sudden DeathLopullinen julkaistu versio, 670 KBLisenssi: CC BY

Siteeraa tätä

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T1 - Accumulation of Lewy-Related Pathology Starts in Middle Age

T2 - The Tampere Sudden Death Study

AU - Kok, Eloise H.

AU - Paetau, Anders

AU - Martiskainen, Mika

AU - Lyytikäinen, Leo-Pekka

AU - Lehtimäki, Terho

AU - Karhunen, Pekka

AU - Myllykangas, Liisa

PY - 2024/5

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N2 - When effective treatments against neurodegenerative diseases become a reality, it will be important to know the age these pathologies begin to develop. We investigated alpha-synuclein pathology in brain tissue of the Tampere Sudden Death Study—unselected forensic autopsies on individuals living outside hospital institutions in Finland. Of 562 (16–95 years) participants, 42 were positive for Lewy-related pathology (LRP). The youngest LRP case was aged 54 years, and the frequency of LRP in individuals aged ≥50 years was 9%. This forensic autopsy study indicates LRP starts already in middle age and is more common than expected in the ≥50 years-of-age non-hospitalized population. ANN NEUROL 2024;95:843–848.

AB - When effective treatments against neurodegenerative diseases become a reality, it will be important to know the age these pathologies begin to develop. We investigated alpha-synuclein pathology in brain tissue of the Tampere Sudden Death Study—unselected forensic autopsies on individuals living outside hospital institutions in Finland. Of 562 (16–95 years) participants, 42 were positive for Lewy-related pathology (LRP). The youngest LRP case was aged 54 years, and the frequency of LRP in individuals aged ≥50 years was 9%. This forensic autopsy study indicates LRP starts already in middle age and is more common than expected in the ≥50 years-of-age non-hospitalized population. ANN NEUROL 2024;95:843–848.

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