Abstrakti
Acetalated dextran (Ac-DEX) is a pH-responsive dextran derivative polymer. Prepared by a simple acetalation reaction, Ac-DEX has tunable acid-triggered release profile. Despite its relatively short research history, Ac-DEX has shown great potential in various therapeutic applications. Furthermore, the recent functionalization of Ac-DEX makes versatile derivatives with additional properties. Herein, we summarize the cutting-edge development of Ac-DEX and related polymers. Specifically, we focus on the chemical synthesis, nano- and micro-particle fabrication techniques, the controlled-release mechanisms, and the rational design Ac-DEX-based of drug delivery systems in various biomedical applications. Finally, we briefly discuss the challenges and future perspectives in the field.
Alkuperäiskieli | englanti |
---|---|
Lehti | Chemical Communications |
Vuosikerta | 57 |
Numero | 35 |
Sivut | 4212-4229 |
Sivumäärä | 18 |
ISSN | 1359-7345 |
DOI - pysyväislinkit | |
Tila | Julkaistu - 2 toukok. 2021 |
OKM-julkaisutyyppi | A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä, vertaisarvioitu |
Lisätietoja
Correction: Acetalated dextran based nano- and microparticles: synthesis, fabrication, and therapeutic applicationsChem. Commun., 2021,57, 4468
DOI: 10.1039/d1cc90141a
Tieteenalat
- 317 Farmasia