TY - JOUR
T1 - Adherent-invasive Escherichia coli associated with granulomatous colitis and extraintestinal dissemination in a Sphynx cat
AU - Tuomisto, Laura Maaria
AU - Kant, Ravi
AU - Kiviranta, Anna-Mariam
AU - Helkiö, Kukka-Maaria
AU - Sironen, Tarja
AU - Sukura, Antti
AU - P. Wilkes, Rebecca
AU - Kegler, Kristel
PY - 2023/5
Y1 - 2023/5
N2 - This case report describes a case of granulomatous colitis (GC) associated with adherent-invasive Escherichia coli (AIEC) with extension to cecum and ileum and dissemination to multiple lymph nodes, the spleen, and brain in a 10-year-old, male Sphynx cat. The cat had an episode of diarrhea 4 months prior to consultation due to sudden blindness. Signs rapidly progressed to ataxia, seizures, and death. Gross and histologic findings were consistent with granulomatous inflammation in all affected organs. In situ hybridization confirmed the presence of intracellular E. coli within enterocytes and infiltrating macrophages, and whole genome sequencing identified virulence traits commonly linked to AIEC strain. This is the first characterization of GC in a cat associated to AIEC resembling the metastatic form of Crohn's disease in humans and GC of dogs. Extraintestinal involvement might provide evidence of the ability of AIEC to promote granulomatous inflammation beyond the gut.
AB - This case report describes a case of granulomatous colitis (GC) associated with adherent-invasive Escherichia coli (AIEC) with extension to cecum and ileum and dissemination to multiple lymph nodes, the spleen, and brain in a 10-year-old, male Sphynx cat. The cat had an episode of diarrhea 4 months prior to consultation due to sudden blindness. Signs rapidly progressed to ataxia, seizures, and death. Gross and histologic findings were consistent with granulomatous inflammation in all affected organs. In situ hybridization confirmed the presence of intracellular E. coli within enterocytes and infiltrating macrophages, and whole genome sequencing identified virulence traits commonly linked to AIEC strain. This is the first characterization of GC in a cat associated to AIEC resembling the metastatic form of Crohn's disease in humans and GC of dogs. Extraintestinal involvement might provide evidence of the ability of AIEC to promote granulomatous inflammation beyond the gut.
KW - Aiec
KW - Cat
KW - Extraintestinal dissemination
KW - Granulomatous colitis
KW - adherent-invasive Escherichia coli
KW - 413 Veterinary science
U2 - 10.1177/03009858231162204
DO - 10.1177/03009858231162204
M3 - Article
SN - 0300-9858
VL - 60
SP - 336
EP - 340
JO - Veterinary Pathology
JF - Veterinary Pathology
IS - 3
ER -