ALS and Parkinson's disease genes CHCHD10 and CHCHD2 modify synaptic transcriptomes in human iPSC-derived motor neurons

Sandra Harjuhaahto; Tiina S. Rasila; Svetlana M. Molchanova; Rosa Woldegebriel; Jouni Kvist; Svetlana Konovalova; Markus T. Sainio; Jana Pennonen; Ruben Torregrosa-Munumer; Hazem Ibrahim; Timo Otonkoski; Tomi Taira; Emil Ylikallio; Henna Tyynismaa

doi:10.1016/j.nbd.2020.104940

ALS and Parkinson's disease genes CHCHD10 and CHCHD2 modify synaptic transcriptomes in human iPSC-derived motor neurons

Sandra Harjuhaahto, Tiina S. Rasila, Svetlana M. Molchanova, Rosa Woldegebriel, Jouni Kvist, Svetlana Konovalova, Markus T. Sainio, Jana Pennonen, Ruben Torregrosa-Munumer, Hazem Ibrahim, Timo Otonkoski, Tomi Taira, Emil Ylikallio, Henna Tyynismaa

Tutkimustuotos: Artikkelijulkaisu › Artikkeli › Tieteellinen › vertaisarvioitu

Alkuperäiskieli	englanti
Artikkeli	104940
Lehti	Neurobiology of Disease
Vuosikerta	141
Sivumäärä	14
ISSN	0969-9961
DOI - pysyväislinkit	https://doi.org/10.1016/j.nbd.2020.104940
Tila	Julkaistu - heinäk. 2020
OKM-julkaisutyyppi	A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä, vertaisarvioitu

Tieteenalat

3112 Neurotieteet
3124 Neurologia ja psykiatria

Pääsy asiakirjaan

10.1016/j.nbd.2020.104940

1-s2.0-S0969996120302151-mainLopullinen julkaistu versio, 4,02 MBLisenssi: CC BY-NC-ND

Siteeraa tätä

Harjuhaahto, S., Rasila, T. S., Molchanova, S. M., Woldegebriel, R., Kvist, J., Konovalova, S., Sainio, M. T., Pennonen, J., Torregrosa-Munumer, R., Ibrahim, H., Otonkoski, T., Taira, T., Ylikallio, E., & Tyynismaa, H. (2020). ALS and Parkinson's disease genes CHCHD10 and CHCHD2 modify synaptic transcriptomes in human iPSC-derived motor neurons. Neurobiology of Disease, 141, Artikkeli 104940. https://doi.org/10.1016/j.nbd.2020.104940

@article{ea62df6436bc42f9a31d188473b40646,

title = "ALS and Parkinson's disease genes CHCHD10 and CHCHD2 modify synaptic transcriptomes in human iPSC-derived motor neurons",

keywords = "CHCHD2, CHCHD10, Induced pluripotent stem cell, Motor neuron differentiation, CMT2, SMAJ, ALS, Mitochondria, CRISPR/Cas9, RNA sequencing, AMYOTROPHIC-LATERAL-SCLEROSIS, PLURIPOTENT STEM-CELLS, ENERGY-METABOLISM, MUTATIONS, POTENTIATION, RECEPTORS, GLUTAMATE, RELEASE, DPP6, 3112 Neurosciences, 3124 Neurology and psychiatry",

author = "Sandra Harjuhaahto and Rasila, {Tiina S.} and Molchanova, {Svetlana M.} and Rosa Woldegebriel and Jouni Kvist and Svetlana Konovalova and Sainio, {Markus T.} and Jana Pennonen and Ruben Torregrosa-Munumer and Hazem Ibrahim and Timo Otonkoski and Tomi Taira and Emil Ylikallio and Henna Tyynismaa",

year = "2020",

month = jul,

doi = "10.1016/j.nbd.2020.104940",

language = "English",

volume = "141",

journal = "Neurobiology of Disease",

issn = "0969-9961",

publisher = "ACADEMIC PRESS INC ELSEVIER SCIENCE",

}

Harjuhaahto, S, Rasila, TS, Molchanova, SM, Woldegebriel, R, Kvist, J , Konovalova, S, Sainio, MT, Pennonen, J , Torregrosa-Munumer, R , Ibrahim, H , Otonkoski, T , Taira, T , Ylikallio, E & Tyynismaa, H 2020, 'ALS and Parkinson's disease genes CHCHD10 and CHCHD2 modify synaptic transcriptomes in human iPSC-derived motor neurons', Neurobiology of Disease, Vuosikerta 141, 104940. https://doi.org/10.1016/j.nbd.2020.104940

TY - JOUR

T1 - ALS and Parkinson's disease genes CHCHD10 and CHCHD2 modify synaptic transcriptomes in human iPSC-derived motor neurons

AU - Harjuhaahto, Sandra

AU - Rasila, Tiina S.

AU - Molchanova, Svetlana M.

AU - Woldegebriel, Rosa

AU - Kvist, Jouni

AU - Konovalova, Svetlana

AU - Sainio, Markus T.

AU - Pennonen, Jana

AU - Torregrosa-Munumer, Ruben

AU - Ibrahim, Hazem

AU - Otonkoski, Timo

AU - Taira, Tomi

AU - Ylikallio, Emil

AU - Tyynismaa, Henna

PY - 2020/7

Y1 - 2020/7

KW - CHCHD2

KW - CHCHD10

KW - Induced pluripotent stem cell

KW - Motor neuron differentiation

KW - CMT2

KW - SMAJ

KW - ALS

KW - Mitochondria

KW - CRISPR/Cas9

KW - RNA sequencing

KW - AMYOTROPHIC-LATERAL-SCLEROSIS

KW - PLURIPOTENT STEM-CELLS

KW - ENERGY-METABOLISM

KW - MUTATIONS

KW - POTENTIATION

KW - RECEPTORS

KW - GLUTAMATE

KW - RELEASE

KW - DPP6

KW - 3112 Neurosciences

KW - 3124 Neurology and psychiatry

U2 - 10.1016/j.nbd.2020.104940

DO - 10.1016/j.nbd.2020.104940

M3 - Article

SN - 0969-9961

VL - 141

JO - Neurobiology of Disease

JF - Neurobiology of Disease

M1 - 104940

ER -