An extensive pattern of atypical neural speech-sound discrimination in newborns at risk of dyslexia

Anja Thiede, Paula Virtala, Iina Ala-Kurikka, Eino Partanen, Minna Huotilainen, Kaija Mikkola, Paavo HT Leppänen, Teija Kujala

Tutkimustuotos: ArtikkelijulkaisuArtikkeliTieteellinenvertaisarvioitu

Kuvaus

Objective: Identifying early signs of developmental dyslexia, associated with deficient speech-sound processing, is paramount to establish early interventions. We aimed to find early speech-sound processing deficiencies in dyslexia, expecting diminished and atypically lateralized event-related potentials (ERP) and mismatch responses (MMR) in newborns at dyslexia risk.

Methods: ERPs were recorded to a pseudoword and its variants (vowel-duration, vowel-identity, and syllable-frequency changes) from 88 newborns at high or no familial risk. The response significance was tested, and group, laterality, and frontality effects were assessed with repeated-measures ANOVA.

Results: An early positive and right-lateralized ERP component was elicited by standard pseudowords in both groups, the response amplitude not differing between groups. Early negative MMRs were absent in the at-risk group, and MMRs to duration changes diminished compared to controls. MMRs to vowel changes had significant laterality x group interactions resulting from right-lateralized MMRs in controls.

Conclusions: The MMRs of high-risk infants were absent or diminished, and morphologically atypical, suggesting atypical neural speech-sound discrimination.

Significance: This atypical neural basis for speech discrimination may contribute to impaired language development, potentially leading to future reading problems. (C) 2019 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. All rights reserved.

Alkuperäiskielienglanti
LehtiClinical Neurophysiology
Vuosikerta130
Numero5
Sivut634-646
Sivumäärä13
ISSN1388-2457
DOI - pysyväislinkit
TilaJulkaistu - toukokuuta 2019
OKM-julkaisutyyppiA1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä, vertaisarvioitu

Tieteenalat

  • 6162 Kognitiotiede
  • 3112 Neurotieteet
  • 515 Psykologia

Lainaa tätä

@article{719916062ae04495b05ad794306e2d55,
title = "An extensive pattern of atypical neural speech-sound discrimination in newborns at risk of dyslexia",
abstract = "Objective: Identifying early signs of developmental dyslexia, associated with deficient speech-sound processing, is paramount to establish early interventions. We aimed to find early speech-sound processing deficiencies in dyslexia, expecting diminished and atypically lateralized event-related potentials (ERP) and mismatch responses (MMR) in newborns at dyslexia risk.Methods: ERPs were recorded to a pseudoword and its variants (vowel-duration, vowel-identity, and syllable-frequency changes) from 88 newborns at high or no familial risk. The response significance was tested, and group, laterality, and frontality effects were assessed with repeated-measures ANOVA.Results: An early positive and right-lateralized ERP component was elicited by standard pseudowords in both groups, the response amplitude not differing between groups. Early negative MMRs were absent in the at-risk group, and MMRs to duration changes diminished compared to controls. MMRs to vowel changes had significant laterality x group interactions resulting from right-lateralized MMRs in controls.Conclusions: The MMRs of high-risk infants were absent or diminished, and morphologically atypical, suggesting atypical neural speech-sound discrimination.Significance: This atypical neural basis for speech discrimination may contribute to impaired language development, potentially leading to future reading problems. (C) 2019 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. All rights reserved.",
keywords = "AUDITORY-DISCRIMINATION, Auditory, BRAIN RESPONSES, CORTICAL RESPONSES, DEVELOPMENTAL DYSLEXIA, Dyslexia, EARLY LANGUAGE-ACQUISITION, EVENT-RELATED POTENTIALS, Event-related potential (ERP), FAMILIAL RISK, GENETIC RISK, MISMATCH NEGATIVITY MMN, Mismatch response (MMR), Newborn, PHONEME MISMATCH, Speech sound, 6162 Cognitive science, 3112 Neurosciences, 515 Psychology",
author = "Anja Thiede and Paula Virtala and Iina Ala-Kurikka and Eino Partanen and Minna Huotilainen and Kaija Mikkola and Lepp{\"a}nen, {Paavo HT} and Teija Kujala",
year = "2019",
month = "5",
doi = "10.1016/j.clinph.2019.01.019",
language = "English",
volume = "130",
pages = "634--646",
journal = "Clinical Neurophysiology",
issn = "1388-2457",
publisher = "ELSEVIER IRELAND LTD",
number = "5",

}

An extensive pattern of atypical neural speech-sound discrimination in newborns at risk of dyslexia. / Thiede, Anja; Virtala, Paula; Ala-Kurikka, Iina; Partanen, Eino; Huotilainen, Minna; Mikkola, Kaija; Leppänen, Paavo HT; Kujala, Teija.

julkaisussa: Clinical Neurophysiology, Vuosikerta 130, Nro 5, 05.2019, s. 634-646.

Tutkimustuotos: ArtikkelijulkaisuArtikkeliTieteellinenvertaisarvioitu

TY - JOUR

T1 - An extensive pattern of atypical neural speech-sound discrimination in newborns at risk of dyslexia

AU - Thiede, Anja

AU - Virtala, Paula

AU - Ala-Kurikka, Iina

AU - Partanen, Eino

AU - Huotilainen, Minna

AU - Mikkola, Kaija

AU - Leppänen, Paavo HT

AU - Kujala, Teija

PY - 2019/5

Y1 - 2019/5

N2 - Objective: Identifying early signs of developmental dyslexia, associated with deficient speech-sound processing, is paramount to establish early interventions. We aimed to find early speech-sound processing deficiencies in dyslexia, expecting diminished and atypically lateralized event-related potentials (ERP) and mismatch responses (MMR) in newborns at dyslexia risk.Methods: ERPs were recorded to a pseudoword and its variants (vowel-duration, vowel-identity, and syllable-frequency changes) from 88 newborns at high or no familial risk. The response significance was tested, and group, laterality, and frontality effects were assessed with repeated-measures ANOVA.Results: An early positive and right-lateralized ERP component was elicited by standard pseudowords in both groups, the response amplitude not differing between groups. Early negative MMRs were absent in the at-risk group, and MMRs to duration changes diminished compared to controls. MMRs to vowel changes had significant laterality x group interactions resulting from right-lateralized MMRs in controls.Conclusions: The MMRs of high-risk infants were absent or diminished, and morphologically atypical, suggesting atypical neural speech-sound discrimination.Significance: This atypical neural basis for speech discrimination may contribute to impaired language development, potentially leading to future reading problems. (C) 2019 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. All rights reserved.

AB - Objective: Identifying early signs of developmental dyslexia, associated with deficient speech-sound processing, is paramount to establish early interventions. We aimed to find early speech-sound processing deficiencies in dyslexia, expecting diminished and atypically lateralized event-related potentials (ERP) and mismatch responses (MMR) in newborns at dyslexia risk.Methods: ERPs were recorded to a pseudoword and its variants (vowel-duration, vowel-identity, and syllable-frequency changes) from 88 newborns at high or no familial risk. The response significance was tested, and group, laterality, and frontality effects were assessed with repeated-measures ANOVA.Results: An early positive and right-lateralized ERP component was elicited by standard pseudowords in both groups, the response amplitude not differing between groups. Early negative MMRs were absent in the at-risk group, and MMRs to duration changes diminished compared to controls. MMRs to vowel changes had significant laterality x group interactions resulting from right-lateralized MMRs in controls.Conclusions: The MMRs of high-risk infants were absent or diminished, and morphologically atypical, suggesting atypical neural speech-sound discrimination.Significance: This atypical neural basis for speech discrimination may contribute to impaired language development, potentially leading to future reading problems. (C) 2019 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. All rights reserved.

KW - AUDITORY-DISCRIMINATION

KW - Auditory

KW - BRAIN RESPONSES

KW - CORTICAL RESPONSES

KW - DEVELOPMENTAL DYSLEXIA

KW - Dyslexia

KW - EARLY LANGUAGE-ACQUISITION

KW - EVENT-RELATED POTENTIALS

KW - Event-related potential (ERP)

KW - FAMILIAL RISK

KW - GENETIC RISK

KW - MISMATCH NEGATIVITY MMN

KW - Mismatch response (MMR)

KW - Newborn

KW - PHONEME MISMATCH

KW - Speech sound

KW - 6162 Cognitive science

KW - 3112 Neurosciences

KW - 515 Psychology

U2 - 10.1016/j.clinph.2019.01.019

DO - 10.1016/j.clinph.2019.01.019

M3 - Article

VL - 130

SP - 634

EP - 646

JO - Clinical Neurophysiology

JF - Clinical Neurophysiology

SN - 1388-2457

IS - 5

ER -