Analysis of Biologics Molecular Descriptors towards Predictive Modelling for Protein Drug Development Using Time-Gated Raman Spectroscopy

Jaakko Itkonen; Leo Ghemtio; Daniela Pellegrino; Pia J. Jokela (nee Heinonen); Henri Xhaard; Marco G. Casteleijn

doi:10.3390/pharmaceutics14081639

Analysis of Biologics Molecular Descriptors towards Predictive Modelling for Protein Drug Development Using Time-Gated Raman Spectroscopy

Jaakko Itkonen, Leo Ghemtio, Daniela Pellegrino, Pia J. Jokela (nee Heinonen), Henri Xhaard, Marco G. Casteleijn

Tutkimustuotos: Artikkelijulkaisu › Artikkeli › Tieteellinen › vertaisarvioitu

Alkuperäiskieli	englanti
Artikkeli	1639
Lehti	Pharmaceutics
Vuosikerta	14
Numero	8
Sivumäärä	18
ISSN	1999-4923
DOI - pysyväislinkit	https://doi.org/10.3390/pharmaceutics14081639
Tila	Julkaistu - elok. 2022
OKM-julkaisutyyppi	A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä, vertaisarvioitu

Tieteenalat

317 Farmasia

Pääsy asiakirjaan

10.3390/pharmaceutics14081639Lisenssi: CC BY

http://hdl.handle.net/10138/346894Lisenssi: CC BY

Siteeraa tätä

@article{c097c267b4fe461aa99a41d9b66b24ea,

title = "Analysis of Biologics Molecular Descriptors towards Predictive Modelling for Protein Drug Development Using Time-Gated Raman Spectroscopy",

keywords = "pharmaceutical proteins, Raman spectroscopy, PCA, K-means clustering, in-line measurement, biologics, protein unfolding, CD, DLS, tryptophan fluorescence, PRINCIPAL COMPONENT ANALYSIS, TRIOSEPHOSPHATE ISOMERASE, CIRCULAR-DICHROISM, STABILITY, AGGREGATION, GLYCOSYLATION, SPECTRA, CONFORMATION, FORMULATION, MECHANISMS, 317 Pharmacy",

author = "Jaakko Itkonen and Leo Ghemtio and Daniela Pellegrino and {Jokela (nee Heinonen)}, {Pia J.} and Henri Xhaard and Casteleijn, {Marco G.}",

year = "2022",

month = aug,

doi = "10.3390/pharmaceutics14081639",

language = "English",

volume = "14",

journal = "Pharmaceutics",

issn = "1999-4923",

publisher = "MDPI",

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TY - JOUR

T1 - Analysis of Biologics Molecular Descriptors towards Predictive Modelling for Protein Drug Development Using Time-Gated Raman Spectroscopy

AU - Itkonen, Jaakko

AU - Ghemtio, Leo

AU - Pellegrino, Daniela

AU - Jokela (nee Heinonen), Pia J.

AU - Xhaard, Henri

AU - Casteleijn, Marco G.

PY - 2022/8

Y1 - 2022/8

KW - pharmaceutical proteins

KW - Raman spectroscopy

KW - PCA

KW - K-means clustering

KW - in-line measurement

KW - biologics

KW - protein unfolding

KW - CD

KW - DLS

KW - tryptophan fluorescence

KW - PRINCIPAL COMPONENT ANALYSIS

KW - TRIOSEPHOSPHATE ISOMERASE

KW - CIRCULAR-DICHROISM

KW - STABILITY

KW - AGGREGATION

KW - GLYCOSYLATION

KW - SPECTRA

KW - CONFORMATION

KW - FORMULATION

KW - MECHANISMS

KW - 317 Pharmacy

U2 - 10.3390/pharmaceutics14081639

DO - 10.3390/pharmaceutics14081639

M3 - Article

SN - 1999-4923

VL - 14

JO - Pharmaceutics

JF - Pharmaceutics

IS - 8

M1 - 1639

ER -