Antibacterial and antibiofilm activity of permanently ionized quaternary ammonium fluoroquinolones

Joanna Fedorowicz; Cristina D. Cruz; Małgorzata Morawska; Krzesimir Ciura; Shella Gilbert-Girard; Liliana Mazur; Heidi Mäkkylä; Polina Ilina; Kirsi Savijoki; Adyary Fallarero; Päivi Tammela; Jarosław Sączewski

doi:10.1016/j.ejmech.2023.115373

Antibacterial and antibiofilm activity of permanently ionized quaternary ammonium fluoroquinolones

Joanna Fedorowicz, Cristina D. Cruz, Małgorzata Morawska, Krzesimir Ciura, Shella Gilbert-Girard, Liliana Mazur, Heidi Mäkkylä, Polina Ilina, Kirsi Savijoki, Adyary Fallarero, Päivi Tammela, Jarosław Sączewski

Tutkimustuotos: Artikkelijulkaisu › Artikkeli › Tieteellinen › vertaisarvioitu

Alkuperäiskieli	englanti
Artikkeli	115373
Lehti	European Journal of Medicinal Chemistry
Vuosikerta	254
Sivumäärä	14
ISSN	0223-5234
DOI - pysyväislinkit	https://doi.org/10.1016/j.ejmech.2023.115373
Tila	Julkaistu - 5 kesäk. 2023
OKM-julkaisutyyppi	A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä, vertaisarvioitu

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Funding Information:
This work was supported by the Polish National Agency for Academic Exchange [grant number PPN/BEK/2019/1/00217]; the Academy of Finland (grant no. 321551), and Medical University of Gdańsk (Poland) subsidies. We thank OpenEye Scientific Software, Santa Fe, NM., for free academic licenses for the use of their software, and the DDCB core facility supported by the University of Helsinki (HiLIFE) and Biocenter Finland for access to bioactivity screening facilities.The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Joanna Fedorowicz reports financial support was provided by Polish National Agency for Academic Exchange. Paivi Tammela reports financial support was provided by Academy of Finland. Joanna Fedorowicz reports financial support was provided by Medical University of Gdansk. Jaroslaw Saczewski reports equipment, drugs, or supplies was provided by OpenEye Scientific Software. Paivi Tammela reports equipment, drugs, or supplies was provided by University of Helsinki.

Funding Information:
This work was supported by the Polish National Agency for Academic Exchange [grant number PPN/BEK/2019/1/00217 ]; the Academy of Finland (grant no. 321551 ), and Medical University of Gdańsk (Poland) subsidies . We thank OpenEye Scientific Software, Santa Fe, NM., for free academic licenses for the use of their software, and the DDCB core facility supported by the University of Helsinki (HiLIFE) and Biocenter Finland for access to bioactivity screening facilities.

Publisher Copyright:
© 2023 The Authors

Tieteenalat

317 Farmasia
116 Kemia

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10.1016/j.ejmech.2023.115373Lisenssi: CC BY

1-s2.0-S0223523423003392-mainLopullinen julkaistu versio, 4,86 MBLisenssi: CC BY

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Link to publication in Scopus

NO-ESCAPE: Evolving the next generation of Gram-negative antimicrobials through a synergetic approach encompassing medicinal chemistry, microbiology and nanomedicine tools
Ilina, P., Yashin, V., Wrigstedt, P., Durante Cruz, C., Perea-Buceta, J. E. & Tammela, P.
Suomen Akatemia Projektilaskutus
01/09/2019 → 31/08/2023
Projekti: Tutkimusprojekti

Siteeraa tätä

Fedorowicz, J., Cruz, C. D., Morawska, M., Ciura, K., Gilbert-Girard, S., Mazur, L., Mäkkylä, H., Ilina, P., Savijoki, K., Fallarero, A., Tammela, P., & Sączewski, J. (2023). Antibacterial and antibiofilm activity of permanently ionized quaternary ammonium fluoroquinolones. European Journal of Medicinal Chemistry, 254, Artikkeli 115373. https://doi.org/10.1016/j.ejmech.2023.115373

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title = "Antibacterial and antibiofilm activity of permanently ionized quaternary ammonium fluoroquinolones",

keywords = "Antibacterial activity, Antibiofilm activity, Molecular docking, Pseudomonas aeruginosa, Quaternary ammonium compounds, Quinolone, 317 Pharmacy, 116 Chemical sciences",

author = "Joanna Fedorowicz and Cruz, {Cristina D.} and Ma{\l}gorzata Morawska and Krzesimir Ciura and Shella Gilbert-Girard and Liliana Mazur and Heidi M{\"a}kkyl{\"a} and Polina Ilina and Kirsi Savijoki and Adyary Fallarero and P{\"a}ivi Tammela and Jaros{\l}aw S{\c a}czewski",

note = "Publisher Copyright: {\textcopyright} 2023 The Authors",

year = "2023",

month = jun,

day = "5",

doi = "10.1016/j.ejmech.2023.115373",

language = "English",

volume = "254",

journal = "European Journal of Medicinal Chemistry",

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Fedorowicz, J, Cruz, CD, Morawska, M, Ciura, K, Gilbert-Girard, S, Mazur, L, Mäkkylä, H, Ilina, P , Savijoki, K , Fallarero, A , Tammela, P & Sączewski, J 2023, 'Antibacterial and antibiofilm activity of permanently ionized quaternary ammonium fluoroquinolones', European Journal of Medicinal Chemistry, Vuosikerta 254, 115373. https://doi.org/10.1016/j.ejmech.2023.115373

TY - JOUR

T1 - Antibacterial and antibiofilm activity of permanently ionized quaternary ammonium fluoroquinolones

AU - Fedorowicz, Joanna

AU - Cruz, Cristina D.

AU - Morawska, Małgorzata

AU - Ciura, Krzesimir

AU - Gilbert-Girard, Shella

AU - Mazur, Liliana

AU - Mäkkylä, Heidi

AU - Ilina, Polina

AU - Savijoki, Kirsi

AU - Fallarero, Adyary

AU - Tammela, Päivi

AU - Sączewski, Jarosław

PY - 2023/6/5

Y1 - 2023/6/5

KW - Antibacterial activity

KW - Antibiofilm activity

KW - Molecular docking

KW - Pseudomonas aeruginosa

KW - Quaternary ammonium compounds

KW - Quinolone

KW - 317 Pharmacy

KW - 116 Chemical sciences

UR - http://www.scopus.com/inward/record.url?scp=85152720668&partnerID=8YFLogxK

U2 - 10.1016/j.ejmech.2023.115373

DO - 10.1016/j.ejmech.2023.115373

M3 - Article

AN - SCOPUS:85152720668

SN - 0223-5234

VL - 254

JO - European Journal of Medicinal Chemistry

JF - European Journal of Medicinal Chemistry

M1 - 115373

ER -

Antibacterial and antibiofilm activity of permanently ionized quaternary ammonium fluoroquinolones

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Projektit

NO-ESCAPE: Evolving the next generation of Gram-negative antimicrobials through a synergetic approach encompassing medicinal chemistry, microbiology and nanomedicine tools

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