Apolipoprotein E (APOE) and lipoprotein lipase (LPL) gene variants and carotid atherosclerotic lesions in the oldest old: a population-based autopsy study

Liisa Myllykangas, G. Alistair Lammie, Irma-Leena Notkola, Raimo Sulkava, Tuomo Polvikoski

    Tutkimustuotos: ArtikkelijulkaisuArtikkeliTieteellinenvertaisarvioitu

    Kuvaus

    We investigated the association between histologically defined atherosclerotic lesions in the carotid arteries and the genetic variants of APOE and LPL in a population-based sample of Finns aged 85 or over. Post-mortem analysis of carotid arteries was performed in 240 subjects. Atherosclerotic lesions were categorized according to the modified American Heart Association criteria, and classified into four different categories: pathological intimal thickening (PIT), fibrous cap atheromas (FCA), calcified lesions (CL), and atherosclerotic burden (AB) (a combination of the other three categories). APOE epsilon 4 genetic variant was associated with PIT (p = 0.018) and AB (p = 0.006) in the carotid arteries, and its effect was independent of the serum lipid levels. The genetic variant LPL Ser447Ter was protective against FCA (p = 0.031) and AB (p = 0.012), while APOE epsilon 2 was protective against FCA (p = 0.035). Our results suggest that the APOE epsilon 4, epsilon 2 and LPL Ser447Ter variants may have different roles in the atherosclerotic process and their effects are seen even in the oldest old population. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
    Alkuperäiskielienglanti
    LehtiArchives of Gerontology and Geriatrics
    Vuosikerta49
    Numero1
    Sivut108-112
    Sivumäärä5
    ISSN0167-4943
    DOI - pysyväislinkit
    TilaJulkaistu - 2009
    OKM-julkaisutyyppiA1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä, vertaisarvioitu

    Lainaa tätä

    Myllykangas, Liisa ; Lammie, G. Alistair ; Notkola, Irma-Leena ; Sulkava, Raimo ; Polvikoski, Tuomo. / Apolipoprotein E (APOE) and lipoprotein lipase (LPL) gene variants and carotid atherosclerotic lesions in the oldest old : a population-based autopsy study. Julkaisussa: Archives of Gerontology and Geriatrics. 2009 ; Vuosikerta 49, Nro 1. Sivut 108-112.
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    title = "Apolipoprotein E (APOE) and lipoprotein lipase (LPL) gene variants and carotid atherosclerotic lesions in the oldest old: a population-based autopsy study",
    abstract = "We investigated the association between histologically defined atherosclerotic lesions in the carotid arteries and the genetic variants of APOE and LPL in a population-based sample of Finns aged 85 or over. Post-mortem analysis of carotid arteries was performed in 240 subjects. Atherosclerotic lesions were categorized according to the modified American Heart Association criteria, and classified into four different categories: pathological intimal thickening (PIT), fibrous cap atheromas (FCA), calcified lesions (CL), and atherosclerotic burden (AB) (a combination of the other three categories). APOE epsilon 4 genetic variant was associated with PIT (p = 0.018) and AB (p = 0.006) in the carotid arteries, and its effect was independent of the serum lipid levels. The genetic variant LPL Ser447Ter was protective against FCA (p = 0.031) and AB (p = 0.012), while APOE epsilon 2 was protective against FCA (p = 0.035). Our results suggest that the APOE epsilon 4, epsilon 2 and LPL Ser447Ter variants may have different roles in the atherosclerotic process and their effects are seen even in the oldest old population. (C) 2008 Elsevier Ireland Ltd. All rights reserved.",
    author = "Liisa Myllykangas and Lammie, {G. Alistair} and Irma-Leena Notkola and Raimo Sulkava and Tuomo Polvikoski",
    year = "2009",
    doi = "10.1016/j.archger.2008.05.007",
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    pages = "108--112",
    journal = "Archives of Gerontology and Geriatrics",
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    Apolipoprotein E (APOE) and lipoprotein lipase (LPL) gene variants and carotid atherosclerotic lesions in the oldest old : a population-based autopsy study. / Myllykangas, Liisa; Lammie, G. Alistair; Notkola, Irma-Leena; Sulkava, Raimo; Polvikoski, Tuomo.

    julkaisussa: Archives of Gerontology and Geriatrics, Vuosikerta 49, Nro 1, 2009, s. 108-112.

    Tutkimustuotos: ArtikkelijulkaisuArtikkeliTieteellinenvertaisarvioitu

    TY - JOUR

    T1 - Apolipoprotein E (APOE) and lipoprotein lipase (LPL) gene variants and carotid atherosclerotic lesions in the oldest old

    T2 - a population-based autopsy study

    AU - Myllykangas, Liisa

    AU - Lammie, G. Alistair

    AU - Notkola, Irma-Leena

    AU - Sulkava, Raimo

    AU - Polvikoski, Tuomo

    PY - 2009

    Y1 - 2009

    N2 - We investigated the association between histologically defined atherosclerotic lesions in the carotid arteries and the genetic variants of APOE and LPL in a population-based sample of Finns aged 85 or over. Post-mortem analysis of carotid arteries was performed in 240 subjects. Atherosclerotic lesions were categorized according to the modified American Heart Association criteria, and classified into four different categories: pathological intimal thickening (PIT), fibrous cap atheromas (FCA), calcified lesions (CL), and atherosclerotic burden (AB) (a combination of the other three categories). APOE epsilon 4 genetic variant was associated with PIT (p = 0.018) and AB (p = 0.006) in the carotid arteries, and its effect was independent of the serum lipid levels. The genetic variant LPL Ser447Ter was protective against FCA (p = 0.031) and AB (p = 0.012), while APOE epsilon 2 was protective against FCA (p = 0.035). Our results suggest that the APOE epsilon 4, epsilon 2 and LPL Ser447Ter variants may have different roles in the atherosclerotic process and their effects are seen even in the oldest old population. (C) 2008 Elsevier Ireland Ltd. All rights reserved.

    AB - We investigated the association between histologically defined atherosclerotic lesions in the carotid arteries and the genetic variants of APOE and LPL in a population-based sample of Finns aged 85 or over. Post-mortem analysis of carotid arteries was performed in 240 subjects. Atherosclerotic lesions were categorized according to the modified American Heart Association criteria, and classified into four different categories: pathological intimal thickening (PIT), fibrous cap atheromas (FCA), calcified lesions (CL), and atherosclerotic burden (AB) (a combination of the other three categories). APOE epsilon 4 genetic variant was associated with PIT (p = 0.018) and AB (p = 0.006) in the carotid arteries, and its effect was independent of the serum lipid levels. The genetic variant LPL Ser447Ter was protective against FCA (p = 0.031) and AB (p = 0.012), while APOE epsilon 2 was protective against FCA (p = 0.035). Our results suggest that the APOE epsilon 4, epsilon 2 and LPL Ser447Ter variants may have different roles in the atherosclerotic process and their effects are seen even in the oldest old population. (C) 2008 Elsevier Ireland Ltd. All rights reserved.

    U2 - 10.1016/j.archger.2008.05.007

    DO - 10.1016/j.archger.2008.05.007

    M3 - Article

    VL - 49

    SP - 108

    EP - 112

    JO - Archives of Gerontology and Geriatrics

    JF - Archives of Gerontology and Geriatrics

    SN - 0167-4943

    IS - 1

    ER -