Application of the European Test of Olfactory Capabilities in patients with olfactory impairment

P. Joussain, M. Bessy, F. Faure, D. Bellil, B.N. Landis, M. Hugentobler, H. Tuorila, S. Mustonen, S. Vento, F. Delphin-Combe, P. Krolak-Salmon, C. Rouby, M. Bensafi

Tutkimustuotos: ArtikkelijulkaisuArtikkeliTieteellinenvertaisarvioitu

Kuvaus

A central issue in olfaction concerns the characterization of loss of olfactory function: partial (hyposmia) or total (anosmia). This paper reports the application in a clinical setting of the European Test of Olfactory Capabilities (ETOC), combining odor detection and identification. The study included three phases. In phase 1, anosmics, hyposmics and controls were tested with the 16-items version of the ETOC. In phase 2, a short version of the ETOC was developed: patients with and controls without olfactory impairment were tested on a 6-items ETOC. In phase 3, to predict olfactory impairments in new individuals, the 16-items ETOC was administered on samples of young and older adults, and the 6-items version was applied in samples of young, elderly participants and Alzheimer patients. In phase 1, linear discriminant analysis (LDA) of ETOC scores classified patients and controls with 87.5 % accuracy. In phase 2, LDA provided 84 % correct classification. Results of phase 3 revealed: (1) 16-items ETOC: whereas in young adults, 10 % were classified as hyposmic and 90 % as normosmic, in elderly, 1 % were classified as anosmic, 39 % hyposmic and 60 % normosmic; (2) 6-items ETOC: 15 % of the young adults were classified as having olfactory impairment, compared to 28 % in the older group and 83 % in Alzheimer patients. In conclusion, the ETOC enables characterizing the prevalence of olfactory impairment in young subjects and in normal and pathological aging. Whereas the 16-items ETOC is more discriminant, the short ETOC may provide a fast (5–10 min) tool to assess olfaction in clinical settings.
Alkuperäiskielienglanti
LehtiEuropean Archives of Oto-Rhino-Laryngology
Vuosikerta273
Numero2
Sivut381-390
Sivumäärä10
ISSN0937-4477
DOI - pysyväislinkit
TilaJulkaistu - 2016
OKM-julkaisutyyppiA1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä, vertaisarvioitu

Tieteenalat

  • 3125 Korva-, nenä- ja kurkkutaudit, silmätaudit

Lainaa tätä

Joussain, P., Bessy, M., Faure, F., Bellil, D., Landis, B. N., Hugentobler, M., ... Bensafi, M. (2016). Application of the European Test of Olfactory Capabilities in patients with olfactory impairment. European Archives of Oto-Rhino-Laryngology, 273(2), 381-390. https://doi.org/10.1007/s00405-015-3536-6
Joussain, P. ; Bessy, M. ; Faure, F. ; Bellil, D. ; Landis, B.N. ; Hugentobler, M. ; Tuorila, H. ; Mustonen, S. ; Vento, S. ; Delphin-Combe, F. ; Krolak-Salmon, P. ; Rouby, C. ; Bensafi, M. / Application of the European Test of Olfactory Capabilities in patients with olfactory impairment. Julkaisussa: European Archives of Oto-Rhino-Laryngology. 2016 ; Vuosikerta 273, Nro 2. Sivut 381-390.
@article{ce3378c227714b818977083b1ee776c8,
title = "Application of the European Test of Olfactory Capabilities in patients with olfactory impairment",
abstract = "A central issue in olfaction concerns the characterization of loss of olfactory function: partial (hyposmia) or total (anosmia). This paper reports the application in a clinical setting of the European Test of Olfactory Capabilities (ETOC), combining odor detection and identification. The study included three phases. In phase 1, anosmics, hyposmics and controls were tested with the 16-items version of the ETOC. In phase 2, a short version of the ETOC was developed: patients with and controls without olfactory impairment were tested on a 6-items ETOC. In phase 3, to predict olfactory impairments in new individuals, the 16-items ETOC was administered on samples of young and older adults, and the 6-items version was applied in samples of young, elderly participants and Alzheimer patients. In phase 1, linear discriminant analysis (LDA) of ETOC scores classified patients and controls with 87.5 {\%} accuracy. In phase 2, LDA provided 84 {\%} correct classification. Results of phase 3 revealed: (1) 16-items ETOC: whereas in young adults, 10 {\%} were classified as hyposmic and 90 {\%} as normosmic, in elderly, 1 {\%} were classified as anosmic, 39 {\%} hyposmic and 60 {\%} normosmic; (2) 6-items ETOC: 15 {\%} of the young adults were classified as having olfactory impairment, compared to 28 {\%} in the older group and 83 {\%} in Alzheimer patients. In conclusion, the ETOC enables characterizing the prevalence of olfactory impairment in young subjects and in normal and pathological aging. Whereas the 16-items ETOC is more discriminant, the short ETOC may provide a fast (5–10 min) tool to assess olfaction in clinical settings.",
keywords = "3125 Otorhinolaryngology, ophthalmology",
author = "P. Joussain and M. Bessy and F. Faure and D. Bellil and B.N. Landis and M. Hugentobler and H. Tuorila and S. Mustonen and S. Vento and F. Delphin-Combe and P. Krolak-Salmon and C. Rouby and M. Bensafi",
year = "2016",
doi = "10.1007/s00405-015-3536-6",
language = "English",
volume = "273",
pages = "381--390",
journal = "European Archives of Oto-Rhino-Laryngology",
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Joussain, P, Bessy, M, Faure, F, Bellil, D, Landis, BN, Hugentobler, M, Tuorila, H, Mustonen, S, Vento, S, Delphin-Combe, F, Krolak-Salmon, P, Rouby, C & Bensafi, M 2016, 'Application of the European Test of Olfactory Capabilities in patients with olfactory impairment', European Archives of Oto-Rhino-Laryngology, Vuosikerta 273, Nro 2, Sivut 381-390. https://doi.org/10.1007/s00405-015-3536-6

Application of the European Test of Olfactory Capabilities in patients with olfactory impairment. / Joussain, P. ; Bessy, M.; Faure, F. ; Bellil, D. ; Landis, B.N.; Hugentobler, M. ; Tuorila, H.; Mustonen, S.; Vento, S.; Delphin-Combe, F.; Krolak-Salmon, P.; Rouby, C.; Bensafi, M.

julkaisussa: European Archives of Oto-Rhino-Laryngology, Vuosikerta 273, Nro 2, 2016, s. 381-390.

Tutkimustuotos: ArtikkelijulkaisuArtikkeliTieteellinenvertaisarvioitu

TY - JOUR

T1 - Application of the European Test of Olfactory Capabilities in patients with olfactory impairment

AU - Joussain, P.

AU - Bessy, M.

AU - Faure, F.

AU - Bellil, D.

AU - Landis, B.N.

AU - Hugentobler, M.

AU - Tuorila, H.

AU - Mustonen, S.

AU - Vento, S.

AU - Delphin-Combe, F.

AU - Krolak-Salmon, P.

AU - Rouby, C.

AU - Bensafi, M.

PY - 2016

Y1 - 2016

N2 - A central issue in olfaction concerns the characterization of loss of olfactory function: partial (hyposmia) or total (anosmia). This paper reports the application in a clinical setting of the European Test of Olfactory Capabilities (ETOC), combining odor detection and identification. The study included three phases. In phase 1, anosmics, hyposmics and controls were tested with the 16-items version of the ETOC. In phase 2, a short version of the ETOC was developed: patients with and controls without olfactory impairment were tested on a 6-items ETOC. In phase 3, to predict olfactory impairments in new individuals, the 16-items ETOC was administered on samples of young and older adults, and the 6-items version was applied in samples of young, elderly participants and Alzheimer patients. In phase 1, linear discriminant analysis (LDA) of ETOC scores classified patients and controls with 87.5 % accuracy. In phase 2, LDA provided 84 % correct classification. Results of phase 3 revealed: (1) 16-items ETOC: whereas in young adults, 10 % were classified as hyposmic and 90 % as normosmic, in elderly, 1 % were classified as anosmic, 39 % hyposmic and 60 % normosmic; (2) 6-items ETOC: 15 % of the young adults were classified as having olfactory impairment, compared to 28 % in the older group and 83 % in Alzheimer patients. In conclusion, the ETOC enables characterizing the prevalence of olfactory impairment in young subjects and in normal and pathological aging. Whereas the 16-items ETOC is more discriminant, the short ETOC may provide a fast (5–10 min) tool to assess olfaction in clinical settings.

AB - A central issue in olfaction concerns the characterization of loss of olfactory function: partial (hyposmia) or total (anosmia). This paper reports the application in a clinical setting of the European Test of Olfactory Capabilities (ETOC), combining odor detection and identification. The study included three phases. In phase 1, anosmics, hyposmics and controls were tested with the 16-items version of the ETOC. In phase 2, a short version of the ETOC was developed: patients with and controls without olfactory impairment were tested on a 6-items ETOC. In phase 3, to predict olfactory impairments in new individuals, the 16-items ETOC was administered on samples of young and older adults, and the 6-items version was applied in samples of young, elderly participants and Alzheimer patients. In phase 1, linear discriminant analysis (LDA) of ETOC scores classified patients and controls with 87.5 % accuracy. In phase 2, LDA provided 84 % correct classification. Results of phase 3 revealed: (1) 16-items ETOC: whereas in young adults, 10 % were classified as hyposmic and 90 % as normosmic, in elderly, 1 % were classified as anosmic, 39 % hyposmic and 60 % normosmic; (2) 6-items ETOC: 15 % of the young adults were classified as having olfactory impairment, compared to 28 % in the older group and 83 % in Alzheimer patients. In conclusion, the ETOC enables characterizing the prevalence of olfactory impairment in young subjects and in normal and pathological aging. Whereas the 16-items ETOC is more discriminant, the short ETOC may provide a fast (5–10 min) tool to assess olfaction in clinical settings.

KW - 3125 Otorhinolaryngology, ophthalmology

U2 - 10.1007/s00405-015-3536-6

DO - 10.1007/s00405-015-3536-6

M3 - Article

VL - 273

SP - 381

EP - 390

JO - European Archives of Oto-Rhino-Laryngology

JF - European Archives of Oto-Rhino-Laryngology

SN - 0937-4477

IS - 2

ER -