Arabidopsis RCD1 coordinates chloroplast and mitochondrial functions through interaction with ANAC transcription factors

Alexey Shapiguzov, Julia Vainonen, Kerri Alyssa Hunter, Helena P M Tossavainen, Arjun Tiwari, Sari Järvi, Maarit Helena Hellman, Fayezeh Aarabi, Saleh Alseekh, Brecht Wybouw, Katrien Van Der Kelen, Lauri Nikkanen, Julia Krasensky-Wrzaczek, Nina Hannele Sipari, Markku Keinänen, Esa Tyystjaervi, Eevi Rintamäki, Bert De Rybel, Jarkko Tapani Salojärvi, Frank Van Breusegem & 6 muut Alisdair R. Fernie, Mikael Johan Brosche, Perttu Esko Ilari Permi, Eva-Mari Aro, Michael Alois Wrzaczek, Jaakko Sakari Kangasjärvi

Tutkimustuotos: ArtikkelijulkaisuArtikkeliTieteellinenvertaisarvioitu

Kuvaus

Reactive oxygen species (ROS)-dependent signaling pathways from chloroplasts and mitochondria merge at the nuclear protein RADICAL-INDUCED CELL DEATH1 (RCD1). RCD1 interacts in vivo and suppresses the activity of the transcription factors ANAC013 and ANAC017, which mediate a ROS-related retrograde signal originating from mitochondrial complex III. Inactivation of RCD1 leads to increased expression of mitochondrial dysfunction stimulon (MDS) genes regulated by ANAC013 and ANAC017. Accumulating MDS gene products, including alternative oxidases (AOXs), affect redox status of the chloroplasts, leading to changes in chloroplast ROS processing and increased protection of photosynthetic apparatus. ROS alter the abundance, thiol redox state and oligomerization of the RCD1 protein in vivo, providing feedback control on its function. RCD1-dependent regulation is linked to chloroplast signaling by 3'-phosphoadenosine 5'-phosphate (PAP). Thus, RCD1 integrates organellar signaling from chloroplasts and mitochondria to establish transcriptional control over the metabolic processes in both organelles.
Alkuperäiskielienglanti
Artikkelie43284
LehtieLife
Vuosikerta8
Sivumäärä35
ISSN2050-084X
DOI - pysyväislinkit
TilaJulkaistu - 15 helmikuuta 2019
OKM-julkaisutyyppiA1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä, vertaisarvioitu

Tieteenalat

  • 1183 Kasvibiologia, mikrobiologia, virologia

Lainaa tätä

Shapiguzov, Alexey ; Vainonen, Julia ; Hunter, Kerri Alyssa ; Tossavainen, Helena P M ; Tiwari, Arjun ; Järvi, Sari ; Hellman, Maarit Helena ; Aarabi, Fayezeh ; Alseekh, Saleh ; Wybouw, Brecht ; Van Der Kelen, Katrien ; Nikkanen, Lauri ; Krasensky-Wrzaczek, Julia ; Sipari, Nina Hannele ; Keinänen, Markku ; Tyystjaervi, Esa ; Rintamäki, Eevi ; De Rybel, Bert ; Salojärvi, Jarkko Tapani ; Van Breusegem, Frank ; Fernie, Alisdair R. ; Brosche, Mikael Johan ; Permi, Perttu Esko Ilari ; Aro, Eva-Mari ; Wrzaczek, Michael Alois ; Kangasjärvi, Jaakko Sakari. / Arabidopsis RCD1 coordinates chloroplast and mitochondrial functions through interaction with ANAC transcription factors. Julkaisussa: eLife. 2019 ; Vuosikerta 8.
@article{7cdce09c0e404cc192985c595f453a2b,
title = "Arabidopsis RCD1 coordinates chloroplast and mitochondrial functions through interaction with ANAC transcription factors",
abstract = "Reactive oxygen species (ROS)-dependent signaling pathways from chloroplasts and mitochondria merge at the nuclear protein RADICAL-INDUCED CELL DEATH1 (RCD1). RCD1 interacts in vivo and suppresses the activity of the transcription factors ANAC013 and ANAC017, which mediate a ROS-related retrograde signal originating from mitochondrial complex III. Inactivation of RCD1 leads to increased expression of mitochondrial dysfunction stimulon (MDS) genes regulated by ANAC013 and ANAC017. Accumulating MDS gene products, including alternative oxidases (AOXs), affect redox status of the chloroplasts, leading to changes in chloroplast ROS processing and increased protection of photosynthetic apparatus. ROS alter the abundance, thiol redox state and oligomerization of the RCD1 protein in vivo, providing feedback control on its function. RCD1-dependent regulation is linked to chloroplast signaling by 3'-phosphoadenosine 5'-phosphate (PAP). Thus, RCD1 integrates organellar signaling from chloroplasts and mitochondria to establish transcriptional control over the metabolic processes in both organelles.",
keywords = "ALTERNATIVE OXIDASES, CELL-DEATH, CYCLIC ELECTRON FLOW, ENZYME-ACTIVITIES, GENES-ENCODING MITOCHONDRIAL, OXIDATIVE STRESS-RESPONSE, PLANT-MITOCHONDRIA, PROTEIN COMPLEXES, RETROGRADE REGULATION, SIGNALING PATHWAYS, 1183 Plant biology, microbiology, virology",
author = "Alexey Shapiguzov and Julia Vainonen and Hunter, {Kerri Alyssa} and Tossavainen, {Helena P M} and Arjun Tiwari and Sari J{\"a}rvi and Hellman, {Maarit Helena} and Fayezeh Aarabi and Saleh Alseekh and Brecht Wybouw and {Van Der Kelen}, Katrien and Lauri Nikkanen and Julia Krasensky-Wrzaczek and Sipari, {Nina Hannele} and Markku Kein{\"a}nen and Esa Tyystjaervi and Eevi Rintam{\"a}ki and {De Rybel}, Bert and Saloj{\"a}rvi, {Jarkko Tapani} and {Van Breusegem}, Frank and Fernie, {Alisdair R.} and Brosche, {Mikael Johan} and Permi, {Perttu Esko Ilari} and Eva-Mari Aro and Wrzaczek, {Michael Alois} and Kangasj{\"a}rvi, {Jaakko Sakari}",
year = "2019",
month = "2",
day = "15",
doi = "10.7554/eLife.43284",
language = "English",
volume = "8",
journal = "eLife",
issn = "2050-084X",
publisher = "ELIFE SCIENCES PUBLICATIONS LTD",

}

Shapiguzov, A, Vainonen, J, Hunter, KA, Tossavainen, HPM, Tiwari, A, Järvi, S, Hellman, MH, Aarabi, F, Alseekh, S, Wybouw, B, Van Der Kelen, K, Nikkanen, L, Krasensky-Wrzaczek, J, Sipari, NH, Keinänen, M, Tyystjaervi, E, Rintamäki, E, De Rybel, B, Salojärvi, JT, Van Breusegem, F, Fernie, AR, Brosche, MJ, Permi, PEI, Aro, E-M, Wrzaczek, MA & Kangasjärvi, JS 2019, 'Arabidopsis RCD1 coordinates chloroplast and mitochondrial functions through interaction with ANAC transcription factors' eLife, Vuosikerta 8, e43284. https://doi.org/10.7554/eLife.43284

Arabidopsis RCD1 coordinates chloroplast and mitochondrial functions through interaction with ANAC transcription factors. / Shapiguzov, Alexey; Vainonen, Julia; Hunter, Kerri Alyssa; Tossavainen, Helena P M; Tiwari, Arjun; Järvi, Sari; Hellman, Maarit Helena; Aarabi, Fayezeh; Alseekh, Saleh; Wybouw, Brecht; Van Der Kelen, Katrien; Nikkanen, Lauri; Krasensky-Wrzaczek, Julia; Sipari, Nina Hannele; Keinänen, Markku; Tyystjaervi, Esa; Rintamäki, Eevi; De Rybel, Bert; Salojärvi, Jarkko Tapani; Van Breusegem, Frank; Fernie, Alisdair R.; Brosche, Mikael Johan; Permi, Perttu Esko Ilari; Aro, Eva-Mari; Wrzaczek, Michael Alois; Kangasjärvi, Jaakko Sakari.

julkaisussa: eLife, Vuosikerta 8, e43284, 15.02.2019.

Tutkimustuotos: ArtikkelijulkaisuArtikkeliTieteellinenvertaisarvioitu

TY - JOUR

T1 - Arabidopsis RCD1 coordinates chloroplast and mitochondrial functions through interaction with ANAC transcription factors

AU - Shapiguzov, Alexey

AU - Vainonen, Julia

AU - Hunter, Kerri Alyssa

AU - Tossavainen, Helena P M

AU - Tiwari, Arjun

AU - Järvi, Sari

AU - Hellman, Maarit Helena

AU - Aarabi, Fayezeh

AU - Alseekh, Saleh

AU - Wybouw, Brecht

AU - Van Der Kelen, Katrien

AU - Nikkanen, Lauri

AU - Krasensky-Wrzaczek, Julia

AU - Sipari, Nina Hannele

AU - Keinänen, Markku

AU - Tyystjaervi, Esa

AU - Rintamäki, Eevi

AU - De Rybel, Bert

AU - Salojärvi, Jarkko Tapani

AU - Van Breusegem, Frank

AU - Fernie, Alisdair R.

AU - Brosche, Mikael Johan

AU - Permi, Perttu Esko Ilari

AU - Aro, Eva-Mari

AU - Wrzaczek, Michael Alois

AU - Kangasjärvi, Jaakko Sakari

PY - 2019/2/15

Y1 - 2019/2/15

N2 - Reactive oxygen species (ROS)-dependent signaling pathways from chloroplasts and mitochondria merge at the nuclear protein RADICAL-INDUCED CELL DEATH1 (RCD1). RCD1 interacts in vivo and suppresses the activity of the transcription factors ANAC013 and ANAC017, which mediate a ROS-related retrograde signal originating from mitochondrial complex III. Inactivation of RCD1 leads to increased expression of mitochondrial dysfunction stimulon (MDS) genes regulated by ANAC013 and ANAC017. Accumulating MDS gene products, including alternative oxidases (AOXs), affect redox status of the chloroplasts, leading to changes in chloroplast ROS processing and increased protection of photosynthetic apparatus. ROS alter the abundance, thiol redox state and oligomerization of the RCD1 protein in vivo, providing feedback control on its function. RCD1-dependent regulation is linked to chloroplast signaling by 3'-phosphoadenosine 5'-phosphate (PAP). Thus, RCD1 integrates organellar signaling from chloroplasts and mitochondria to establish transcriptional control over the metabolic processes in both organelles.

AB - Reactive oxygen species (ROS)-dependent signaling pathways from chloroplasts and mitochondria merge at the nuclear protein RADICAL-INDUCED CELL DEATH1 (RCD1). RCD1 interacts in vivo and suppresses the activity of the transcription factors ANAC013 and ANAC017, which mediate a ROS-related retrograde signal originating from mitochondrial complex III. Inactivation of RCD1 leads to increased expression of mitochondrial dysfunction stimulon (MDS) genes regulated by ANAC013 and ANAC017. Accumulating MDS gene products, including alternative oxidases (AOXs), affect redox status of the chloroplasts, leading to changes in chloroplast ROS processing and increased protection of photosynthetic apparatus. ROS alter the abundance, thiol redox state and oligomerization of the RCD1 protein in vivo, providing feedback control on its function. RCD1-dependent regulation is linked to chloroplast signaling by 3'-phosphoadenosine 5'-phosphate (PAP). Thus, RCD1 integrates organellar signaling from chloroplasts and mitochondria to establish transcriptional control over the metabolic processes in both organelles.

KW - ALTERNATIVE OXIDASES

KW - CELL-DEATH

KW - CYCLIC ELECTRON FLOW

KW - ENZYME-ACTIVITIES

KW - GENES-ENCODING MITOCHONDRIAL

KW - OXIDATIVE STRESS-RESPONSE

KW - PLANT-MITOCHONDRIA

KW - PROTEIN COMPLEXES

KW - RETROGRADE REGULATION

KW - SIGNALING PATHWAYS

KW - 1183 Plant biology, microbiology, virology

U2 - 10.7554/eLife.43284

DO - 10.7554/eLife.43284

M3 - Article

VL - 8

JO - eLife

JF - eLife

SN - 2050-084X

M1 - e43284

ER -