Arabidopsis RCD1 coordinates chloroplast and mitochondrial functions through interaction with ANAC transcription factors

Alexey Shapiguzov, Julia Vainonen, Kerri Alyssa Hunter, Helena P M Tossavainen, Arjun Tiwari, Sari Järvi, Maarit Helena Hellman, Fayezeh Aarabi, Saleh Alseekh, Brecht Wybouw, Katrien Van Der Kelen, Lauri Nikkanen, Julia Krasensky-Wrzaczek, Nina Hannele Sipari, Markku Keinänen, Esa Tyystjaervi, Eevi Rintamäki, Bert De Rybel, Jarkko Tapani Salojärvi, Frank Van BreusegemAlisdair R. Fernie, Mikael Johan Brosche, Perttu Esko Ilari Permi, Eva-Mari Aro, Michael Alois Wrzaczek, Jaakko Sakari Kangasjärvi

Tutkimustuotos: ArtikkelijulkaisuArtikkeliTieteellinenvertaisarvioitu

Abstrakti

Reactive oxygen species (ROS)-dependent signaling pathways from chloroplasts and mitochondria merge at the nuclear protein RADICAL-INDUCED CELL DEATH1 (RCD1). RCD1 interacts in vivo and suppresses the activity of the transcription factors ANAC013 and ANAC017, which mediate a ROS-related retrograde signal originating from mitochondrial complex III. Inactivation of RCD1 leads to increased expression of mitochondrial dysfunction stimulon (MDS) genes regulated by ANAC013 and ANAC017. Accumulating MDS gene products, including alternative oxidases (AOXs), affect redox status of the chloroplasts, leading to changes in chloroplast ROS processing and increased protection of photosynthetic apparatus. ROS alter the abundance, thiol redox state and oligomerization of the RCD1 protein in vivo, providing feedback control on its function. RCD1-dependent regulation is linked to chloroplast signaling by 3'-phosphoadenosine 5'-phosphate (PAP). Thus, RCD1 integrates organellar signaling from chloroplasts and mitochondria to establish transcriptional control over the metabolic processes in both organelles.
Alkuperäiskielienglanti
Artikkelie43284
LehtieLife
Vuosikerta8
Sivumäärä35
ISSN2050-084X
DOI - pysyväislinkit
TilaJulkaistu - 15 helmikuuta 2019
OKM-julkaisutyyppiA1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä, vertaisarvioitu

Tieteenalat

  • 1183 Kasvibiologia, mikrobiologia, virologia

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